INT117967

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.24
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 99.96 Very High Very High Very High
agonist 35 99.20 Very High Very High Very High
Action potential 9 96.84 Very High Very High Very High
imagery 17 92.40 High High
Adelta 1 83.04 Quite High
Pain 5 80.44 Quite High
qutenza 15 79.92 Quite High
adenocard 26 78.00 Quite High
Glutamate 22 73.92 Quite High
Central nervous system 7 72.96 Quite High
Disease Link Frequency Relevance Heat
Death 13 81.92 Quite High
Pain 8 80.44 Quite High
Nociception 34 79.56 Quite High
Inflammatory Pain 2 50.00 Quite Low
Injury 17 34.04 Quite Low
INFLAMMATION 22 33.76 Quite Low
Cv Unclassified Under Development 11 29.52 Quite Low
Neurodegenerative Disease 4 16.16 Low Low
Middle Cerebral Artery Infarction 29 15.12 Low Low
Epilepsy 29 6.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect was specific for P2Y2/P2Y4 receptors, as the P2Y6 ligand UDP never activated C fibers.
P2Y4 Binding (specific) of
1) Confidence 0.36 Published 2004 Journal Pain Section Abstract Doc Link 15082124 Disease Relevance 0.16 Pain Relevance 0.51
In addition, a key role for P2X7 receptors is established as well as possibly contributory roles for P2X2, P2X4, P2X5, P2Y2, P2Y4 and P2Y14 based on agonist preferences [40].
P2Y4 Binding (roles) of associated with agonist
2) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0 Pain Relevance 0.18
Both P2Y12 and P2Y13 are activated by ADP [16], but, P2Y13 is the only P2Y receptor with high affinity for IDP.
P2Y receptor Binding (affinity) of
3) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2865444 Disease Relevance 0 Pain Relevance 0.33
Both effects were partially counteracted by the P2Y receptor antagonist cangrelor (ibidem).
P2Y receptor Binding (counteracted) of associated with antagonist
4) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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