INT117980

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.72
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
neurons 2
blood 1
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 20 98.92 Very High Very High Very High
backache 6 96.40 Very High Very High Very High
nMDA receptor 12 95.64 Very High Very High Very High
Pain 21 87.44 High High
depression 1 82.16 Quite High
Analgesic 1 79.68 Quite High
ischemia 9 76.36 Quite High
Hippocampus 48 69.76 Quite High
Glutamate 235 64.56 Quite High
Migraine 2 63.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 378 99.84 Very High Very High Very High
Cv Unclassified Under Development 17 99.68 Very High Very High Very High
Headache 20 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 8 96.92 Very High Very High Very High
Low Back Pain 6 96.56 Very High Very High Very High
Glioma 33 91.40 High High
Pain 18 87.44 High High
Skin Cancer 8 83.20 Quite High
Depression 1 82.16 Quite High
Wiskott-aldrich Syndrome 2 73.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The statistical power of the study was high enough to warrant the conclusion that there is no clinically significant effect of botulinum toxin A on chronic tension-type headache.
Neg (no) Regulation (effect) of botulinum toxin associated with headache
1) Confidence 0.45 Published 2004 Journal Pain Section Abstract Doc Link 15082132 Disease Relevance 0.75 Pain Relevance 0.79
For example, the haploinsufficiency or deletion of Rac1 in these systems is from early embryogenesis and this has been shown to induce changes in blood pressure and vasodilation [24] that, in turn, are known to affect neovascularization indirectly [33] and therefore it is likely that such changes in blood pressure would actually affect angiogenesis in the Rac1-haploinsufficient-Tie2-Cre mice.
Regulation (affect) of Rac1 in blood associated with cv unclassified under development and increased venous pressure under development
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.51 Pain Relevance 0.04
Thus the most logical assumption is simply that Rac1 is not involved in tumor angioegenesis in vivo unless ?
Neg (not) Regulation (involved) of Rac1 associated with cancer
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0
As captured in the network, genes for partners of PTK2B were also up-regulated in Glud1 hippocampal neurons, including the protein kinase Prkca and the small GTPase Rac1 (RAS-Related C3 Botulinum Substrate 1).


Regulation (regulated) of Rac1 in neurons
4) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.07 Pain Relevance 0.16
As captured in the network, genes for partners of PTK2B were also up-regulated in Glud1 hippocampal neurons, including the protein kinase Prkca and the small GTPase Rac1 (RAS-Related C3 Botulinum Substrate 1).


Regulation (regulated) of RAS-Related C3 Botulinum Substrate 1 in neurons
5) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.07 Pain Relevance 0.16
The observed effect of simvastatin on protein isoprenylation of RhoA and Rac1 is due to a shortage of geranylgeranyl pyrophosphate, and it was previously shown that this shortage can be replenished by the addition of mevalonate or GGOH (Houten et al 2003b).
Regulation (effect) of Rac1
6) Confidence 0.30 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.26 Pain Relevance 0
To target mouse Rac1 gene we used siGENOME ON-TARGETplus SMARTpool reagent (Dharmacon).
Regulation (target) of Rac1
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.06 Pain Relevance 0
As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).
Neg (no) Regulation (changes) of Rac1
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
Hence, we evaluated the effect of MU-sh and MC-sh treatments on several molecules such as FAK, talin1, talin2, profilin, vinculin, actinin, tensin, Rac1 and Arp2 in both the xenograft cell lines by using RT-PCR analysis.
Regulation (effect) of Rac1
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.52 Pain Relevance 0
Foster et al (2001) conducted a randomized, placebo-controlled, double-blinded study of Botulinum toxin A versus saline injection in 31 patients with unilateral or predominantly unilateral low back pain.
Regulation (controlled) of Botulinum toxin associated with low back pain and backache
10) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656321 Disease Relevance 0.74 Pain Relevance 0.74

General Comments

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