INT117995

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.40
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
Anatomy Link Frequency
nerve 2
photoreceptor cells 2
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 6 99.56 Very High Very High Very High
Neuritis 1 89.44 High High
sodium channel 2 52.80 Quite High
transdermal 6 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 6 99.56 Very High Very High Very High
Aging 44 99.42 Very High Very High Very High
Reprotox - General 2 72 98.76 Very High Very High Very High
Coronary Artery Disease 7 98.56 Very High Very High Very High
Cardiovascular Disease 13 97.68 Very High Very High Very High
Hypertension 4 95.80 Very High Very High Very High
Diabetes Mellitus 30 94.44 High High
Ocular Toxicity (including Many Sub-types) 3 92.84 High High
Testosterone Deficiency 3 92.24 High High
Optic Neuritis 1 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, PDE5 inhibitors are safe and effective in most patient populations, including men with ischemic cardiovascular disease or those receiving anti-hypertensive agents, and men with diabetes or those who have undergone nerve-sparing retropubic radical prostatectomy.
Regulation (effective) of Negative_regulation (inhibitors) of PDE5 in nerve associated with diabetes mellitus, cardiovascular disease and hypertension
1) Confidence 0.44 Published 2004 Journal J Am Osteopath Assoc Section Abstract Doc Link 15083994 Disease Relevance 0.89 Pain Relevance 0.10
Theoretically, PDE inhibitor may change the retinal physiology in two ways; an alteration of the phototransduction process by PDE6 inhibition at the photoreceptor cells, and an alteration in vascular flow by PDE5 inhibition at the vascular smooth muscle.
Regulation (alteration) of Negative_regulation (inhibition) of PDE5 in photoreceptor cells
2) Confidence 0.33 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816895 Disease Relevance 0.66 Pain Relevance 0.19
It seems that adequate testosterone levels are an important influence on sexual symptoms in the aging male and also influence the response of men to PDE-5 inhibitors, the first line treatment for erectile dysfunction in men.
Regulation (response) of Negative_regulation (inhibitors) of PDE-5 associated with reprotox - general 2 and aging
3) Confidence 0.20 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.86 Pain Relevance 0

General Comments

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