INT117998

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
embryonic kidney 2
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 5 98.64 Very High Very High Very High
Root ganglion neuron 1 91.20 High High
Inflammation 40 76.12 Quite High
fibrosis 5 74.24 Quite High
nociceptor 1 25.00 Low Low
ischemia 1 10.80 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 90.88 High High
Systemic Sclerosis 30 88.28 High High
Apoptosis 3 85.36 High High
Vasculitis 4 83.76 Quite High
INFLAMMATION 40 76.12 Quite High
Fibrosis 4 74.24 Quite High
Frailty 1 73.20 Quite High
Necrosis 4 71.60 Quite High
Injury 9 71.24 Quite High
Cardiovascular Disease 7 66.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, they also found that, in the absence of SRC, a significant increase in arterial fibrointimal thickness was observed in dcSSc patients, and to a lesser extent in lcSSc patients, compared to controls.
Positive_regulation (increase) of Neg (absence) Gene_expression (absence) of SRC
1) Confidence 0.36 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 0.80 Pain Relevance 0.08
Src-kinase as well as transfection of cells with short interference RNA (siRNA)
Positive_regulation (transfection) of Gene_expression (transfection) of Src
2) Confidence 0.11 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.47 Pain Relevance 0.03
The availability of these synthetic EETs has made it possible to evaluate another regioisomer, 14,15-EET. 14,15-EET was shown to induce angiogenesis via several pathways including: Src, phospatidylinositol-3-kinase/Akt (PI3K/Akt) signaling in parallel with mTOR-S6K1 activation and Src-dependent STAT-3-mediated VEGF expression [108, 109].
Positive_regulation (activation) of Gene_expression (expression) of Src-dependent
3) Confidence 0.06 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.09 Pain Relevance 0
PP2 also abolished currents in human embryonic kidney-293 cells transfected with rat TRPV1, whereas cotransfection of TRPV1 with v-Src resulted in fivefold increase in capsaicin-induced currents.
Positive_regulation (cotransfection) of Gene_expression (cotransfection) of v-Src in embryonic kidney associated with qutenza
4) Confidence 0.05 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15084474 Disease Relevance 0.09 Pain Relevance 0.40

General Comments

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