INT118004

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 11.05
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
lung 4
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 5 99.52 Very High Very High Very High
Immobilon 4 92.64 High High
Root ganglion neuron 1 87.00 High High
cytokine 24 86.68 High High
nociceptor 1 25.00 Low Low
addiction 2 17.76 Low Low
antagonist 12 5.00 Very Low Very Low Very Low
opiate 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 552 99.92 Very High Very High Very High
Cancer 329 99.92 Very High Very High Very High
Prostate Cancer 53 99.84 Very High Very High Very High
Malignant Neoplastic Disease 8 99.32 Very High Very High Very High
Lung Cancer 16 99.04 Very High Very High Very High
Ovarian Cancer 16 98.52 Very High Very High Very High
Melanoma 8 97.88 Very High Very High Very High
Breast Cancer 16 97.44 Very High Very High Very High
Ganglion Cysts 1 86.68 High High
Adhesions 32 77.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cells transfected with dominant-negative c-Src and TRPV1, capsaicin-induced currents were decreased by approximately fourfold.
Positive_regulation (transfected) of Gene_expression (transfected) of c-Src associated with qutenza
1) Confidence 0.49 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15084474 Disease Relevance 0.09 Pain Relevance 0.40
We then sought to link c-Src and STAT3 in our 3D model through the adenoviral expression of a dominant negative form of c-Src (DNSrc).
Positive_regulation (link) of Gene_expression (expression) of c-Src
2) Confidence 0.49 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
In support of this, other recent studies37, 38 also demonstrate integrin-mediated c-Src activation and FAC formation can contribute to STAT3 phosphorylation/activation.
Positive_regulation (mediated) of Gene_expression (activation) of c-Src
3) Confidence 0.49 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
C-Src is frequently overexpressed and/or aberrantly activated in a variety of epithelial and non-epithelial cancers including colorectal, breast cancers, melanomas, ovarian cancer, lung cancer and pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of C-Src in lung associated with lung cancer, melanoma, cancer, pancreatic cancer, ovarian cancer and breast cancer
4) Confidence 0.35 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.30 Pain Relevance 0.04
Transfection of siRNA against mTOR, Src, Rictor, FKBP12 and Akt
Positive_regulation (Transfection) of Gene_expression (Transfection) of Src
5) Confidence 0.34 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.05
Src kinase was found to be overexpressed in prostate cancer, where Src inhibitors decreased proliferation and invasion of cell lines and xenografts [55], [56].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Src associated with prostate cancer
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.36 Pain Relevance 0
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (-) of Gene_expression (expression) of C-Src associated with pancreatic cancer
7) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (expression) of Gene_expression (expression) of C-Src associated with pancreatic cancer
8) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (-) of Gene_expression (over) of C-Src associated with pancreatic cancer
9) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04
C-Src is frequently overexpressed and/or aberrantly activated in a variety of epithelial and non-epithelial cancers including colorectal, breast cancers, melanomas, ovarian cancer, lung cancer and pancreatic cancer.
Positive_regulation (activated) of Gene_expression (overexpressed) of C-Src in lung associated with lung cancer, melanoma, cancer, pancreatic cancer, ovarian cancer and breast cancer
10) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.32 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (over) of Gene_expression (expression) of C-Src associated with pancreatic cancer
11) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (expression) of Gene_expression (over) of C-Src associated with pancreatic cancer
12) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (over) of Gene_expression (over) of C-Src associated with pancreatic cancer
13) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.33 Pain Relevance 0.04

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