INT11802

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.81
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (KLF1) intracellular (KLF1) DNA binding (KLF1)
Anatomy Link Frequency
plasma cells 1
liver 1
finger 1
bowel 1
KLF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 4 100.00 Very High Very High Very High
Inflammation 3 99.04 Very High Very High Very High
Enkephalin 1 98.40 Very High Very High Very High
Adalimumab 2 95.00 High High
Crohn's disease 7 94.76 High High
Clonidine 2 94.40 High High
Catecholamine 4 85.96 High High
Spinal cord 12 84.88 Quite High
cytokine 2 72.88 Quite High
long-term potentiation 34 70.60 Quite High
Disease Link Frequency Relevance Heat
Immunization 1 99.84 Very High Very High Very High
Inflammatory Bowel Disease 6 99.32 Very High Very High Very High
Influenza Virus Infection 64 99.18 Very High Very High Very High
Necrosis 5 98.30 Very High Very High Very High
Cancer 39 98.12 Very High Very High Very High
Malignant Neoplastic Disease 4 96.68 Very High Very High Very High
Multiple Myeloma 15 95.56 Very High Very High Very High
Breast Cancer 24 95.44 Very High Very High Very High
Disease 52 94.76 High High
Colon Cancer 22 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
the specificity protein/Kruppel-like factor (SP/KLF) family of zinc-finger
Gene_expression (family) of Kruppel-like factor in finger
1) Confidence 0.65 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.12 Pain Relevance 0.12
The number of patients eligible for each monoclonal antibody was estimated based on
Gene_expression (antibody) of monoclonal
2) Confidence 0.12 Published 2008 Journal Current Oncology Section Body Doc Link PMC2442764 Disease Relevance 0.94 Pain Relevance 0.05
Absolute lifetime cost of monoclonal antibody therapy in Canada was calculated as the product of the monoclonal antibody cost per patient per indication (Table I) and the total number of patients in Canada eligible for the relevant treatment, including those with relapsed disease (Figure 2).
Gene_expression (product) of monoclonal associated with disease
3) Confidence 0.12 Published 2008 Journal Current Oncology Section Body Doc Link PMC2442764 Disease Relevance 0.87 Pain Relevance 0.12
Production and characterization of an iminoimidazolidine specific monoclonal antibody using para-aminoclonidine as antigen.
Gene_expression (Production) of monoclonal
4) Confidence 0.08 Published 1992 Journal Life Sci. Section Title Doc Link 1598072 Disease Relevance 0 Pain Relevance 0.17
Production and characterization of an iminoimidazolidine specific monoclonal antibody using para-aminoclonidine as antigen.
Gene_expression (using) of monoclonal
5) Confidence 0.08 Published 1992 Journal Life Sci. Section Title Doc Link 1598072 Disease Relevance 0 Pain Relevance 0.17
Monoclonal antibody (mAb.) against liver ferritin was produced by immunization of human liver ferritin.
Gene_expression (produced) of Monoclonal in liver associated with immunization
6) Confidence 0.06 Published 1986 Journal Gan No Rinsho Section Abstract Doc Link 3747163 Disease Relevance 0.35 Pain Relevance 0.05
Successful production of several proteins in plants, including human serum albumin, haemoglobin, monoclonal antibodies, viral antigens (vaccines), enkephalin, and trichosanthin, has been reported.
Gene_expression (production) of monoclonal associated with enkephalin
7) Confidence 0.05 Published 1997 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 9503395 Disease Relevance 0.16 Pain Relevance 0.10
Strategies aimed at reducing tumour necrosis factor in patients with inflammatory bowel disease include the mouse/human chimeric monoclonal antibody infliximab, the humanized monoclonal antibody CDP571, the human soluble TNF p55 receptor onercept, the human monoclonal antibody D2E7 (adalimumab), the anti-TNF human antibody Fab' fragment-polyethelene glycol (PEG) conjugate CDP870, and the small molecules thalidomide and CNI-1493 (MAP-kinase inhibitor).
Gene_expression (infliximab) of monoclonal in bowel associated with necrosis, infliximab, inflammation, cancer and adalimumab
8) Confidence 0.01 Published 2003 Journal Best Pract Res Clin Gastroenterol Section Abstract Doc Link 12617886 Disease Relevance 1.31 Pain Relevance 0.48
These cells produce monoclonal immunoglobulins, most commonly either immunoglobulin G (IgG) or immunoglobulin A (IgA) [10].
Gene_expression (produce) of monoclonal
9) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923176 Disease Relevance 1.91 Pain Relevance 0.10
Recently, a new technology has been developed where influenza-specific IgG+ antibody-secreting plasma cells can be isolated and cloned directly from vaccinated humans and high affinity monoclonal antibodies can be produced within several weeks after vaccination.
Gene_expression (produced) of monoclonal in plasma cells associated with influenza virus infection
10) Confidence 0.01 Published 2009 Journal Virol J Section Abstract Doc Link PMC2666653 Disease Relevance 0.62 Pain Relevance 0
Undoubtly, the recent finding by Wrammert et al [6] holds great promise for the development of passive antibody therapy against the spread of influenza viruses because (1) high affinity human monoclonal antibodies can be produced in less than a month after vaccination and (2) these antibodies, because of their human origin, will have no or minimal antibody-related side-effects in humans.


Gene_expression (produced) of monoclonal associated with influenza virus infection
11) Confidence 0.01 Published 2009 Journal Virol J Section Body Doc Link PMC2666653 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox