INT11803

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 62
Total Number 62
Disease Relevance 31.44
Pain Relevance 18.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 9
plasma 3
spleen 3
macrophages 2
lymphocyte 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1071 100.00 Very High Very High Very High
chemokine 108 100.00 Very High Very High Very High
narcan 30 99.72 Very High Very High Very High
rheumatoid arthritis 281 99.62 Very High Very High Very High
Morphine 33 99.48 Very High Very High Very High
Inflammation 586 99.24 Very High Very High Very High
metalloproteinase 44 98.74 Very High Very High Very High
Arthritis 162 98.64 Very High Very High Very High
fluoxetine 7 98.50 Very High Very High Very High
opioid receptor 11 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 50 99.98 Very High Very High Very High
Pulmonary Disease 181 99.90 Very High Very High Very High
Arthritis 163 99.84 Very High Very High Very High
Sprains And Strains 191 99.70 Very High Very High Very High
Rheumatoid Arthritis 281 99.62 Very High Very High Very High
Lymphatic System Cancer 23 99.58 Very High Very High Very High
Autoimmune Lymphoproliferative Syndrome 2 99.46 Very High Very High Very High
Cancer 488 99.40 Very High Very High Very High
INFLAMMATION 607 99.24 Very High Very High Very High
Death 89 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data suggested that the stimulative effect of met-enk on lymphocytes may be mediated through the increase of IL-2, but not through the IL-2 receptor expression.
Positive_regulation (increase) of IL-2 in lymphocytes
1) Confidence 0.70 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.20 Pain Relevance 0.14
Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes.
Positive_regulation (activation) of IL-2 in thymocytes associated with morphine
2) Confidence 0.65 Published 1997 Journal Cell. Immunol. Section Title Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.57
These studies demonstrate for the first time that opioid alkaloids such as morphine can impair mitogen-lymphokine-activated thymocyte proliferation by interfering with transcriptional activation of the IL-2 gene.
Positive_regulation (activation) of IL-2 gene in thymocyte associated with opioid and morphine
3) Confidence 0.65 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.62
Administration of paeonol in vivo also elevated serum levels of IL-2 and TNF-alpha in tumor-bearing mice.
Positive_regulation (elevated) of IL-2 associated with cancer
4) Confidence 0.59 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.42 Pain Relevance 0.11
Simultaneous presence of interleukin 1 (IL-1) and interleukin 2 (IL-2) into the cultures counteracted, in a dose-dependent manner, as naloxone does, the immunosuppressive action of PM as well as of Pethidine, a known opioid agonist.
Positive_regulation (presence) of IL-2 associated with mu agonist, algil and narcan
5) Confidence 0.49 Published 1990 Journal Int. J. Neurosci. Section Abstract Doc Link 2176182 Disease Relevance 0 Pain Relevance 0.74
Simultaneous presence of interleukin 1 (IL-1) and interleukin 2 (IL-2) into the cultures counteracted, in a dose-dependent manner, as naloxone does, the immunosuppressive action of PM as well as of Pethidine, a known opioid agonist.
Positive_regulation (presence) of interleukin 2 associated with mu agonist, algil and narcan
6) Confidence 0.49 Published 1990 Journal Int. J. Neurosci. Section Abstract Doc Link 2176182 Disease Relevance 0 Pain Relevance 0.73
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Positive_regulation (activation) of IL-2 in T cells
7) Confidence 0.46 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.21 Pain Relevance 0.04
Furthermore, in the absence of helper cells, induction of IL-2 signaling by an IL-2 immune complex was sufficient to promote memory-like CD8+ T cell self-reactivity.


Positive_regulation (induction) of IL-2 in T cell
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939396 Disease Relevance 0.30 Pain Relevance 0.10
However, excess unlabeled IL-2 was unable to impede the entry of I-IL-2, indicating that this transport is nonsaturable.
Neg (unable) Positive_regulation (excess) of IL-2
9) Confidence 0.45 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 8044683 Disease Relevance 0 Pain Relevance 0.33
Also, via RT-PCR we detected a significant increase of IL-2 and IL-2 receptor gene transcription level after 7 days of oral administration of LcZhang.
Positive_regulation (increase) of IL-2
10) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.52 Pain Relevance 0.21
Also, via RT-PCR we detected a significant increase of IL-2 and IL-2 receptor gene transcription level after 7 days of oral administration of LcZhang.
Positive_regulation (increase) of IL-2
11) Confidence 0.44 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.52 Pain Relevance 0.21
interleukin-2 (IL-2) and IFN, could not be confirmed on the basis of
Positive_regulation (confirmed) of interleukin-2
12) Confidence 0.43 Published 1994 Journal Mediators Inflamm Section Abstract Doc Link PMC2365582 Disease Relevance 0.15 Pain Relevance 0.40
interleukin-2 (IL-2) and IFN, could not be confirmed on the basis of
Positive_regulation (confirmed) of IL-2
13) Confidence 0.43 Published 1994 Journal Mediators Inflamm Section Abstract Doc Link PMC2365582 Disease Relevance 0.15 Pain Relevance 0.40
The presence of the opioid peptides alpha- and beta-endorphin (-End) but not methionine enkephalin (Met-enk) in in vitro cultures of purified CD4+ T cells, stimulated with concanavalin A in the presence of irradiated spleen cells, resulted in a threefold stimulation of IL-2, IL-4, and IFN-gamma production.
Positive_regulation (stimulation) of IL-2 in spleen associated with enkephalin and opioid
14) Confidence 0.40 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.44
Moreover, splenocytes and macrophages isolated from paeonol-treated HepA tumor-bearing mice produced higher levels of IL-2 and TNF-alpha in response to concanavalin A and lipopolysaccharide stimulation, respectively, compared to these isolated from non-treated HepA tumor-bearing mice.
Positive_regulation (levels) of IL-2 in macrophages associated with cancer
15) Confidence 0.40 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.42 Pain Relevance 0.10
Twenty-four hour incubation of mouse splenocytes with MS, removal of the drug and activation with Con-A resulted in a significant (linear regression, P less than 0.001) dose-related inhibition of lymphokine production (IC50 = 0.8 mM) as measured by bioassay for interleukin-2 (IL-2)/interleukin-4 (IL-4).
Positive_regulation (bioassay) of interleukin-2
16) Confidence 0.40 Published 1991 Journal Immunopharmacology Section Abstract Doc Link 1663496 Disease Relevance 0 Pain Relevance 0.71
The cerebrospinal fluid (CSF) contained increased concentrations of interleukin-2.
Positive_regulation (increased) of interleukin-2 in CSF
17) Confidence 0.39 Published 1997 Journal Int. J. Cancer Section Abstract Doc Link 9399653 Disease Relevance 0.36 Pain Relevance 0.09
One cytolytic clone produced neither IL-2 nor IL-4 mRNA to detectable levels, although mRNA for IFN-gamma was observed.
Neg (neither) Positive_regulation (produced) of IL-2
18) Confidence 0.38 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8381052 Disease Relevance 0.32 Pain Relevance 0.09
In contrast, IL-2 and interferon-gamma levels increased after naloxone treatment.
Positive_regulation (increased) of IL-2 associated with narcan
19) Confidence 0.36 Published 2000 Journal Blood Section Abstract Doc Link 10706871 Disease Relevance 0.09 Pain Relevance 1.10
When interleukin (IL)-2, IL-4 and interferon (IFN gamma) levels were measured in FLV-infected cell cultures, both AZT and Met-ENK treatments induced a higher production of IFN gamma and a slight increase in IL-2 and IL-4, as compared with either treatment alone.
Positive_regulation (increase) of IL-2
20) Confidence 0.35 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8968350 Disease Relevance 0.08 Pain Relevance 0.23

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