INT118035

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 10.57
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
Anatomy Link Frequency
immune cells 2
monocyte 1
hepatocytes 1
uterine 1
T cell 1
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 245 99.98 Very High Very High Very High
Neuropeptide 8 97.90 Very High Very High Very High
Opioid 8 97.90 Very High Very High Very High
Inflammation 259 92.76 High High
Enkephalin 1 92.20 High High
corticosteroid 115 88.72 High High
Potency 95 87.84 High High
mu opioid receptor 2 87.04 High High
opioid receptor 3 81.68 Quite High
Bioavailability 18 77.44 Quite High
Disease Link Frequency Relevance Heat
Multiple Myeloma 201 100.00 Very High Very High Very High
Bordatella Infection 1 99.58 Very High Very High Very High
Hepatitis C Virus Infection 455 99.08 Very High Very High Very High
Myeloproliferative Disorder 45 98.96 Very High Very High Very High
Disease Progression 24 98.92 Very High Very High Very High
Leiomyosarcoma 118 98.64 Very High Very High Very High
Malignant Neoplastic Disease 22 97.24 Very High Very High Very High
Stress 34 96.88 Very High Very High Very High
Cancer 187 96.84 Very High Very High Very High
Necrosis 21 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the constitutive activation of the JAK/STAT pathway in JAKV617F+MPN can result in subsequent epigenetic silencing of tumour suppressor genes [27, 28], suggesting that these changes result in further evolution of the disease.
Positive_regulation (activation) of JAK associated with myeloproliferative disorder, cancer and disease
1) Confidence 0.67 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.34 Pain Relevance 0.09
treatment could not strongly induce JAK1 kinase activity in human uterine LMS cell lines.
Neg (not) Positive_regulation (induce) of JAK1 in uterine associated with leiomyosarcoma
2) Confidence 0.48 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.80 Pain Relevance 0
to the type II IFN receptor, JAK1 and JAK2 are activated and phosphorylate the signal transducer and activator of transcription 1(STAT1) on the tyrosine residue at position 701 (Tyr701) and the serine residue at position 727 (Ser727) (Parmar and Platanias, 2005; Platanias, 2005) (Fig. 2).
Positive_regulation (activated) of JAK1
3) Confidence 0.48 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.56 Pain Relevance 0
The mu-opioid-induced activation of STAT3 is sensitive to receptor was further shown to pertussis toxin treatment and required JAK and Src tyrosine kinases, but not phosphatidylinositol 3-kinase.
Neg (not) Positive_regulation (required) of JAK associated with bordatella infection and opioid
4) Confidence 0.20 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194868 Disease Relevance 0.26 Pain Relevance 0.35
Engagementof cell surface Interleukin-6 receptors activates the Janus kinase(JAK) family of tyrosine kinases, which in turn phosphorylate the cytoplasmic part of gp130, thereby creating docking sites for STAT factors STAT1 and STAT3 [38,39].
Positive_regulation (activates) of JAK
5) Confidence 0.19 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.05 Pain Relevance 0
Engagementof cell surface Interleukin-6 receptors activates the Janus kinase(JAK) family of tyrosine kinases, which in turn phosphorylate the cytoplasmic part of gp130, thereby creating docking sites for STAT factors STAT1 and STAT3 [38,39].
Positive_regulation (activates) of Janus
6) Confidence 0.19 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.05 Pain Relevance 0
Small GTPases of the Ras protein superfamily stimulate the tyrosine phosphorylation and activation of the JAK family of intracellular kinases.
Positive_regulation (activation) of JAK
7) Confidence 0.18 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.10 Pain Relevance 0
Activation of the receptor-associated Janus-activated kinase 1 (Jak1) and tyrosine kinase 2 (Tyk2) then, in turn, lead to activation of transcription proteins 1 and 2 (STAT 1 and STAT 2).
Positive_regulation (Activation) of Jak1
8) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.63 Pain Relevance 0.10
Activation of the receptor-associated Janus-activated kinase 1 (Jak1) and tyrosine kinase 2 (Tyk2) then, in turn, lead to activation of transcription proteins 1 and 2 (STAT 1 and STAT 2).
Positive_regulation (Activation) of Janus-activated kinase 1
9) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.63 Pain Relevance 0.10
The activation of Janus-activated kinase 1 and c-Src, implicated in STAT3 activation, was also inhibited by the vanilloid, with no effect on extracellular signal-regulated kinase 1/2 activation.
Positive_regulation (activation) of Janus-activated kinase 1
10) Confidence 0.06 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.08 Pain Relevance 0
Multiple cytokine activated JAK/STAT signaling pathways were potently inhibited with IC50 values below 200 nM.
Positive_regulation (activated) of JAK associated with cytokine
11) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.05 Pain Relevance 0.39
Normal human, mouse or rat whole blood pre-treated with CP-690,550 was stimulated with cytokines, and STAT phosphorylation downstream of receptor-associated JAK activation was monitored in monocyte and T cell populations as summarized in Table 1.
Positive_regulation (activation) of JAK in T cell associated with cytokine
12) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.35
Janus (named after the two-faced God of Gates, Janus) activated kinases (JAK's) are vital intermediaries between cytokine receptors and signal transcription and activation of transduction (STAT), which result in activation of the immune cells [127].
Positive_regulation (activated) of JAK in immune cells associated with cytokine
13) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.22 Pain Relevance 0.27
JAK-1 and JAK-2 are activated by a broad range of cytokines that use gp130 whereas JAK-3 which is highly expressed in lymphoid cells is activated only by cytokines that bind to gamma-chain-containing receptors.
Positive_regulation (activated) of JAK-1 associated with cytokine
14) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.25 Pain Relevance 0.30
that activates JAK/STAT pathway, inhibit HCV replication in human hepatocytes.
Positive_regulation (activates) of JAK in hepatocytes associated with hepatitis c virus infection
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.85 Pain Relevance 0.07
Janus (named after the two-faced God of Gates, Janus) activated kinases (JAK's) are vital intermediaries between cytokine receptors and signal transcription and activation of transduction (STAT), which result in activation of the immune cells [127].
Positive_regulation (activated) of Janus in immune cells associated with cytokine
16) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.22 Pain Relevance 0.27
Oct4 directly or indirectly induces ATSCs reprogramming along with the activation of JAK/STAT3 and ERK1/2.
Positive_regulation (activation) of JAK
17) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.15 Pain Relevance 0
Normal human, mouse or rat whole blood pre-treated with CP-690,550 was stimulated with cytokines, and STAT phosphorylation downstream of receptor-associated JAK activation was monitored in monocyte and T cell populations as summarized in Table 1.
Positive_regulation (activation) of JAK in monocyte associated with cytokine
18) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.35
Stimulatory effects of TNF-alpha on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor, and required activation of ERK 1/2 and p38, but not Janus kinase, MAPKs.
Positive_regulation (activation) of Janus kinase associated with neuropeptide
19) Confidence 0.01 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15087472 Disease Relevance 0.22 Pain Relevance 0.53
This phosphorylation results in the activation of several intracellular second-messenger signal transduction pathways, such as the Janus kinase-Signal transducer an activator of transcription signaling, the phosphatidylinositol-3-kinase and the protein-serine/threonine kinase Akt signal, and the Ras-Raf-MAP-kinase signal, which further activates the mitogen-activated phosphorylation protein kinases.
Positive_regulation (activation) of Janus kinase-Signal
20) Confidence 0.01 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886332 Disease Relevance 0.38 Pain Relevance 0

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