INT11804

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 70
Total Number 74
Disease Relevance 33.00
Pain Relevance 21.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 28
lymphocytes 14
spleen 12
macrophages 4
adrenal gland 4
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 703 100.00 Very High Very High Very High
Pain 103 100.00 Very High Very High Very High
Enkephalin 16 99.86 Very High Very High Very High
qutenza 41 99.82 Very High Very High Very High
antagonist 36 99.78 Very High Very High Very High
anesthesia 7 99.76 Very High Very High Very High
rheumatoid arthritis 163 99.62 Very High Very High Very High
Morphine 34 99.48 Very High Very High Very High
substance P 94 99.02 Very High Very High Very High
psoriasis 99 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 93 100.00 Very High Very High Very High
Apoptosis 42 99.90 Very High Very High Very High
Infection 243 99.80 Very High Very High Very High
Pruritus 81 99.80 Very High Very High Very High
Cancer 662 99.72 Very High Very High Very High
Rheumatoid Arthritis 163 99.62 Very High Very High Very High
Immunization 63 99.54 Very High Very High Very High
Congenital Anomalies 3 99.48 Very High Very High Very High
Targeted Disruption 47 99.18 Very High Very High Very High
Psoriasis 133 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IL-2 production of spleen cells of normal mice was also markedly enhanced by the mixed culture with spleen cells from pain-stimulated mice.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in spleen associated with pain
1) Confidence 0.70 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.73 Pain Relevance 0.80
It can be assumed that activated L3T4- T cells interact with antigen-specific L3T4+ T cells and lead to enhanced IL-2 production.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in T cells
2) Confidence 0.70 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.60 Pain Relevance 0.67
Interleukin-2 production of spleen cells from mice given pain stimulation was significantly increased compared with spleen cells of normal mice.
Positive_regulation (increased) of Gene_expression (production) of Interleukin-2 in spleen associated with pain
3) Confidence 0.70 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.71 Pain Relevance 0.78
These data suggest that the enhanced production of IL-2 in mice given pain stimulation resulted from the activation of L3T4- T cells by endogenous catecholamines released from the adrenal gland after pain stimulation.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in adrenal gland associated with pain and catecholamine
4) Confidence 0.70 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.72 Pain Relevance 0.80
Further study also demonstrated that interleukin-2 (IL-2) production of spleen cells was enhanced in mice by pain stimulation.
Positive_regulation (enhanced) of Gene_expression (production) of interleukin-2 in spleen associated with pain
5) Confidence 0.70 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.55 Pain Relevance 0.60
Enhancement of IL-2 production in the spleen cells of mice given pain stimulation did not occur with anti-Thy-1.2 antibody and complement treatment, but production was maintained by treatment with anti-L3T4 antibody and complement.
Positive_regulation (Enhancement) of Gene_expression (production) of IL-2 in spleen associated with pain
6) Confidence 0.70 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.73 Pain Relevance 0.80
When met-enk (10 nmol.L-1-100 mumol.L-1) was included in Con A-stimulated lymphocyte cultures, the IL-2 production increased in a concentration-dependent manner.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in lymphocyte
7) Confidence 0.70 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.26 Pain Relevance 0.16
Furthermore, in vivo treatment with met-enk also increased IL-2 production of splenocytes, and the enhancement of IL-2 production was parallel to that of lymphocyte proliferation.
Positive_regulation (enhancement) of Gene_expression (production) of IL-2 in lymphocyte
8) Confidence 0.70 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.24 Pain Relevance 0.15
Furthermore, in vivo treatment with met-enk also increased IL-2 production of splenocytes, and the enhancement of IL-2 production was parallel to that of lymphocyte proliferation.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in lymphocyte
9) Confidence 0.70 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.24 Pain Relevance 0.15
After acute subcutaneous administration, tramadol induced antinociception starting from a dose of 20 mg/kg, whereas it significantly enhanced natural killer activity and IL-2 production at doses as low as 1 mg/kg and splenocyte proliferation starting from a dose of 10 mg/kg.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 associated with antinociception and tramadol
10) Confidence 0.70 Published 1997 Journal Pain Section Abstract Doc Link 9313273 Disease Relevance 0.16 Pain Relevance 0.89
These data suggest that the enhanced production of IL-2 in mice given pain stimulation resulted from the activation of L3T4- T cells by endogenous catecholamines released from the adrenal gland after pain stimulation.
Positive_regulation (resulted) of Gene_expression (production) of IL-2 in adrenal gland associated with pain and catecholamine
11) Confidence 0.50 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.72 Pain Relevance 0.80
Further study also demonstrated that interleukin-2 (IL-2) production of spleen cells was enhanced in mice by pain stimulation.
Positive_regulation (enhanced) of Gene_expression (production) of IL-2 in spleen associated with pain
12) Confidence 0.50 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.55 Pain Relevance 0.60
The data suggested that the stimulative effect of met-enk on lymphocytes may be mediated through the increase of IL-2, but not through the IL-2 receptor expression.
Neg (not) Spec (may) Positive_regulation (mediated) of Gene_expression (expression) of IL-2 in lymphocytes
13) Confidence 0.50 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.20 Pain Relevance 0.14
The data suggested that the stimulative effect of met-enk on lymphocytes may be mediated through the increase of IL-2, but not through the IL-2 receptor expression.
Positive_regulation (increase) of Gene_expression (expression) of IL-2 in lymphocytes
14) Confidence 0.50 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.20 Pain Relevance 0.14
The production of antibodies to FECA and IL-2 started after the 21st day and was higher in the group of mice immunized with FECA and with IL-2 than in control animals.
Positive_regulation (started) of Gene_expression (production) of IL-2
15) Confidence 0.50 Published 1993 Journal J Surg Oncol Section Abstract Doc Link 8441268 Disease Relevance 0.57 Pain Relevance 0.10
Further, it was demonstrated that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes and the expression of the IL-22 receptor (IL-22R) was also increased in epidermal lesions versus normal skin.23 IL-17 and IL-22 coordinately enhanced cytokine, chemokine, and growth factor production depending on the amount of IL-22R expression.
Positive_regulation (increased) of in skin Gene_expression (production) of IL-2 in keratinocytes associated with chemokine, psoriasis and cytokine
16) Confidence 0.49 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.08 Pain Relevance 0.50
In vitro treatment with paeonol was able to directly stimulate IL-2 and TNF-alpha production in splenocytes and macrophages from tumor-bearing mice, respectively.
Positive_regulation (stimulate) of Gene_expression (production) of IL-2 in macrophages associated with cancer
17) Confidence 0.43 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.39 Pain Relevance 0.09
Dependence on PGE2 for this response was not found in all clones, as some TH1 cells could produce GM-CSF after IL-2 alone, and some cells did not produce GM-CSF even in the presence of PGE2 and IL-2.
Positive_regulation (after) of Gene_expression (produce) of IL-2 associated with addiction
18) Confidence 0.41 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2521509 Disease Relevance 0.07 Pain Relevance 0.05
Administration of paeonol in vivo also elevated serum levels of IL-2 and TNF-alpha in tumor-bearing mice.
Positive_regulation (elevated) of Gene_expression (levels) of IL-2 associated with cancer
19) Confidence 0.40 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.42 Pain Relevance 0.11
Moreover, splenocytes and macrophages isolated from paeonol-treated HepA tumor-bearing mice produced higher levels of IL-2 and TNF-alpha in response to concanavalin A and lipopolysaccharide stimulation, respectively, compared to these isolated from non-treated HepA tumor-bearing mice.
Positive_regulation (levels) of Gene_expression (produced) of IL-2 in macrophages associated with cancer
20) Confidence 0.40 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.43 Pain Relevance 0.10

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