INT11805

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 6.62
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
lymphocytes 6
T cells 6
liver 3
lymph node 2
Th1 cells 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 24 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
cytokine 181 98.08 Very High Very High Very High
opioid receptor 8 96.80 Very High Very High Very High
opiate 1 94.96 High High
aspirin 1 94.84 High High
antagonist 7 94.40 High High
chemokine 20 94.16 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 19 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
Diabetes Mellitus 52 99.36 Very High Very High Very High
Infection 199 98.72 Very High Very High Very High
Immunization 19 95.98 Very High Very High Very High
Coronary Artery Disease 17 94.32 High High
Necrosis 5 94.00 High High
Cancer 435 93.64 High High
INFLAMMATION 86 90.48 High High
Cv General 3 Under Development 6 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Influences of methionine enkephalin (met-enk) on delayed hypersensitivity (DH) against 2,4-dinitrofluoro-benzene (DNFB) and interleukin-2 (IL-2) production of mouse lymphocytes were examined.
Spec (examined) Regulation (Influences) of Gene_expression (production) of interleukin-2 in lymphocytes associated with hypersensitivity and enkephalin
1) Confidence 0.62 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.30 Pain Relevance 0.17
Influence of methionine-enkephalin on interleukin-2 production and interleukin-2 receptor expression.
Regulation (Influence) of Gene_expression (production) of interleukin-2 associated with enkephalin
2) Confidence 0.62 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 1598829 Disease Relevance 0.28 Pain Relevance 0.20
However, met-enk 10 nmol.L-1 had no effect on IL-2 receptor expression on thymocytes, splenocytes, and gut-associated lymphocytes.
Neg (no) Regulation (effect) of Gene_expression (expression) of IL-2 in lymphocytes
3) Confidence 0.62 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.22 Pain Relevance 0.15
Influence of methionine-enkephalin on interleukin-2 production and interleukin-2 receptor expression.
Regulation (Influence) of Gene_expression (expression) of interleukin-2 associated with enkephalin
4) Confidence 0.62 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 1598829 Disease Relevance 0.29 Pain Relevance 0.20
Influences of methionine enkephalin (met-enk) on delayed hypersensitivity (DH) against 2,4-dinitrofluoro-benzene (DNFB) and interleukin-2 (IL-2) production of mouse lymphocytes were examined.
Spec (examined) Regulation (Influences) of Gene_expression (production) of IL-2 in lymphocytes associated with hypersensitivity and enkephalin
5) Confidence 0.45 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.30 Pain Relevance 0.17
To this end, the effects of various opioid peptides on the production of IL-2, IL-4, IL-6, and interferon-gamma (IFN-gamma) by CD4+ T cells were determined.
Regulation (effects) of Gene_expression (production) of IL-2 in T cells associated with opioid
6) Confidence 0.43 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7914752 Disease Relevance 0 Pain Relevance 0.39
Experiments undertaken to reveal the mechanism of action of opioid peptides suggest an overall enhancement of lymphokine production: (1) enhancement of IL-4 production occurred also in the presence of excess IL-2; and (2) neither IL-1 receptor-antagonizing protein nor anti-IL-6 were capable to abrogate the stimulatory effect on IL-2 and IL-4 production.
Regulation (effect) of Gene_expression (production) of IL-2 associated with opioid
7) Confidence 0.35 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7907006 Disease Relevance 0 Pain Relevance 0.70
On the other hand, the production of IL-2 in response to lymph node T cell stimulation with SEB was not altered by the opioid treatment.
Neg (not) Regulation (altered) of Gene_expression (production) of IL-2 in lymph node associated with opioid
8) Confidence 0.30 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9143250 Disease Relevance 0 Pain Relevance 0.69
It is known that Th1 cells are able to produce IL-2 and IFN-?
Regulation (able) of Gene_expression (produce) of IL-2 in Th1 cells
9) Confidence 0.30 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0.14 Pain Relevance 0.09
Influence of pain stimulation on interleukin-2 production in mice.
Regulation (Influence) of Gene_expression (production) of interleukin-2 associated with pain
10) Confidence 0.27 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 7825812 Disease Relevance 0.54 Pain Relevance 0.68
Calcineurin is a Ca++-dependant enzyme able to regulate the production of IL-2 and TNF?
Regulation (regulate) of Gene_expression (production) of IL-2
11) Confidence 0.23 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.08 Pain Relevance 0.15
Immunofluorescence tests for the study of the expression of E-cadherin and TRPV6 calcium channel, IL-2+ and TNF+ cells, CD4+ and CD8+ T lymphocytes
Regulation (study) of Gene_expression (expression) of IL-2 in T lymphocytes associated with calcium channel
12) Confidence 0.23 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.11 Pain Relevance 0.13
Down-regulation of Treg differentiation by 1,25(OH)2D3 is dependent on the low production of IL-2
Regulation (dependent) of Gene_expression (production) of IL-2
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0 Pain Relevance 0
The in vitro addition of Bv8 did not affect the production of IL-2 and IFN-?
Neg (not) Regulation (affect) of Gene_expression (production) of IL-2
14) Confidence 0.14 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.15 Pain Relevance 0.10
The production of IL-2 and IL-4 was not significantly different from the non-treated control levels.


Neg (not) Regulation (different) of Gene_expression (production) of IL-2
15) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 1.34 Pain Relevance 0.08
Immune exhaustion in P14 cells peaked at day 20 post-clone 13 infection, a time point when P14 cells in spleen and liver had almost no ability to produce IL-2 and TNF-?
Neg (no) Regulation (ability) of Gene_expression (produce) of IL-2 in liver associated with infection
16) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC1899484 Disease Relevance 0.29 Pain Relevance 0.26
Furthermore, while immunization of A20HA bearing mice with HA-expressing virus increased the number and fraction HA-specific T cells that have divided, this "primed population" also had a markedly impaired proliferative response to peptide in vitro, diminished IL-2 production, and failure to make interferon-?
Regulation (peptide) of Gene_expression (production) of IL-2 in T cells associated with immunization
17) Confidence 0.08 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.69 Pain Relevance 0
Interestingly, we observed that the NSPCs were capable of expressing IL-2 mRNA, whose levels underwent a significant increase upon JEV infection (Fig. 5) (p<0.01).
Regulation (capable) of Gene_expression (expressing) of IL-2 mRNA associated with infection
18) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.44 Pain Relevance 0.09
Concerning diabetes, IL-7 is suggested to function through IL-2 production on mature T-cells [14], which can lead to ?
Regulation (through) of Gene_expression (production) of IL-2 in mature T-cells associated with diabetes mellitus
19) Confidence 0.06 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.03 Pain Relevance 0.66
Immune exhaustion in P14 cells peaked at day 20 post-clone 13 infection, a time point when P14 cells in spleen and liver had almost no ability to produce IL-2 and TNF-?
Neg (no) Regulation (ability) of in spleen Gene_expression (produce) of IL-2 in liver associated with infection
20) Confidence 0.04 Published 2007 Journal Virol J Section Body Doc Link PMC1899484 Disease Relevance 0.29 Pain Relevance 0.26

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