INT11806

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.02
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
macrophages 2
lymphocytes 2
T cells 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 75.00 Quite High
rheumatoid arthritis 1 72.84 Quite High
cytokine 42 46.16 Quite Low
Inflammation 32 45.80 Quite Low
Spontaneous pain 5 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
IPN 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 101 98.32 Very High Very High Very High
Immunization 2 75.00 Quite High
Rheumatoid Arthritis 1 72.84 Quite High
Diabetes Mellitus 1 71.64 Quite High
Hypersensitivity 3 71.40 Quite High
Autoimmune Disease 1 70.88 Quite High
Targeted Disruption 1 50.00 Quite Low
INFLAMMATION 37 45.80 Quite Low
Leukemia 2 34.68 Quite Low
Solid Tumor 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data suggested that the stimulative effect of met-enk on lymphocytes may be mediated through the increase of IL-2, but not through the IL-2 receptor expression.
Neg (not) Spec (may) Positive_regulation (mediated) of Positive_regulation (increase) of IL-2 in lymphocytes
1) Confidence 0.50 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.20 Pain Relevance 0.14
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Positive_regulation (leading) of Positive_regulation (activation) of IL-2 in T cells
2) Confidence 0.46 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.22 Pain Relevance 0.04
This procedure not only yielded greater amounts of extract but also with significant increase in immunostimulating activity, which induces activation of human natural killer (NK) cells, macrophages and potent induction of IL-2, IL-12 and IFN-?
Positive_regulation (induces) of Positive_regulation (induction) of IL-2 in macrophages
3) Confidence 0.14 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2892347 Disease Relevance 0.60 Pain Relevance 0

General Comments

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