INT11807

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 7
Speculated 3
Reported most in Abstract
Documents 266
Total Number 271
Disease Relevance 112.00
Pain Relevance 64.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 58
lymphocytes 13
spleen 12
plasma 5
macrophages 3
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2935 100.00 Very High Very High Very High
chemokine 453 100.00 Very High Very High Very High
Morphine 141 100.00 Very High Very High Very High
Calcium channel 60 100.00 Very High Very High Very High
narcan 29 100.00 Very High Very High Very High
withdrawal 27 100.00 Very High Very High Very High
intrathecal 4 99.98 Very High Very High Very High
Demyelination 56 99.96 Very High Very High Very High
Enkephalin 42 99.92 Very High Very High Very High
qutenza 61 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2622 100.00 Very High Very High Very High
Necrosis 147 100.00 Very High Very High Very High
Cold Sores 18 100.00 Very High Very High Very High
Opiate Addiction 9 100.00 Very High Very High Very High
Corneal Neovascularization 74 99.98 Very High Very High Very High
Multiple Sclerosis 1243 99.96 Very High Very High Very High
Demyelinating Disease 180 99.96 Very High Very High Very High
Pulmonary Disease 310 99.90 Very High Very High Very High
Infection 2042 99.84 Very High Very High Very High
Pox Virus Infection 27 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Influence of pain stimulation on interleukin-2 production in mice.
Gene_expression (production) of interleukin-2 associated with pain
1) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 7825812 Disease Relevance 0.54 Pain Relevance 0.68
Further study also demonstrated that interleukin-2 (IL-2) production of spleen cells was enhanced in mice by pain stimulation.
Gene_expression (production) of interleukin-2 in spleen associated with pain
2) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.54 Pain Relevance 0.59
Interleukin-2 production of spleen cells from mice given pain stimulation was significantly increased compared with spleen cells of normal mice.
Gene_expression (production) of Interleukin-2 in spleen associated with pain
3) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.64 Pain Relevance 0.68
It can be assumed that activated L3T4- T cells interact with antigen-specific L3T4+ T cells and lead to enhanced IL-2 production.
Gene_expression (production) of IL-2 in T cells
4) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.59 Pain Relevance 0.67
Enhancement of IL-2 production in the spleen cells of mice given pain stimulation did not occur with anti-Thy-1.2 antibody and complement treatment, but production was maintained by treatment with anti-L3T4 antibody and complement.
Gene_expression (production) of IL-2 in spleen associated with pain
5) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.73 Pain Relevance 0.80
Further study also demonstrated that interleukin-2 (IL-2) production of spleen cells was enhanced in mice by pain stimulation.
Gene_expression (production) of IL-2 in spleen associated with pain
6) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.54 Pain Relevance 0.59
The IL-2 production of spleen cells of normal mice was also markedly enhanced by the mixed culture with spleen cells from pain-stimulated mice.
Gene_expression (production) of IL-2 in spleen associated with pain
7) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.71 Pain Relevance 0.78
These data suggest that the enhanced production of IL-2 in mice given pain stimulation resulted from the activation of L3T4- T cells by endogenous catecholamines released from the adrenal gland after pain stimulation.
Gene_expression (production) of IL-2 in adrenal gland associated with pain and catecholamine
8) Confidence 0.78 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.72 Pain Relevance 0.80
However, met-enk 10 nmol.L-1 had no effect on IL-2 receptor expression on thymocytes, splenocytes, and gut-associated lymphocytes.
Gene_expression (expression) of IL-2 in lymphocytes
9) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.22 Pain Relevance 0.15
Influence of methionine-enkephalin on interleukin-2 production and interleukin-2 receptor expression.
Gene_expression (production) of interleukin-2 associated with enkephalin
10) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 1598829 Disease Relevance 0.28 Pain Relevance 0.20
When met-enk (10 nmol.L-1-100 mumol.L-1) was included in Con A-stimulated lymphocyte cultures, the IL-2 production increased in a concentration-dependent manner.
Gene_expression (production) of IL-2 in lymphocyte
11) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.26 Pain Relevance 0.16
Furthermore, in vivo treatment with met-enk also increased IL-2 production of splenocytes, and the enhancement of IL-2 production was parallel to that of lymphocyte proliferation.
Gene_expression (production) of IL-2 in lymphocyte
12) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.24 Pain Relevance 0.15
The data suggested that the stimulative effect of met-enk on lymphocytes may be mediated through the increase of IL-2, but not through the IL-2 receptor expression.
Gene_expression (expression) of IL-2 in lymphocytes
13) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.20 Pain Relevance 0.14
Furthermore, in vivo treatment with met-enk also increased IL-2 production of splenocytes, and the enhancement of IL-2 production was parallel to that of lymphocyte proliferation.
Gene_expression (production) of IL-2 in lymphocyte
14) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.24 Pain Relevance 0.15
Influences of methionine enkephalin (met-enk) on delayed hypersensitivity (DH) against 2,4-dinitrofluoro-benzene (DNFB) and interleukin-2 (IL-2) production of mouse lymphocytes were examined.
Gene_expression (production) of IL-2 in lymphocytes associated with hypersensitivity and enkephalin
15) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.29 Pain Relevance 0.17
Influence of methionine-enkephalin on interleukin-2 production and interleukin-2 receptor expression.
Gene_expression (expression) of interleukin-2 associated with enkephalin
16) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 1598829 Disease Relevance 0.29 Pain Relevance 0.20
Influences of methionine enkephalin (met-enk) on delayed hypersensitivity (DH) against 2,4-dinitrofluoro-benzene (DNFB) and interleukin-2 (IL-2) production of mouse lymphocytes were examined.
Gene_expression (production) of interleukin-2 in lymphocytes associated with hypersensitivity and enkephalin
17) Confidence 0.78 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1598829 Disease Relevance 0.29 Pain Relevance 0.17
In this study, we evaluated the effects of the acute and chronic administration of tramadol on nociceptive thresholds (by the hot-plate test) and on immune responses (by measuring Concanavalin A-induced splenocyte proliferation, IL-2 production and natural killer activity) in the mouse.
Gene_expression (production) of IL-2 associated with nociception and tramadol
18) Confidence 0.78 Published 1997 Journal Pain Section Abstract Doc Link 9313273 Disease Relevance 0.17 Pain Relevance 0.79
Morphine tolerance and abstinence were associated with suppression of IL-2 production, which was completely blocked by naltrexone.
Gene_expression (production) of IL-2 associated with tolerance and morphine
19) Confidence 0.78 Published 1995 Journal Brain Res. Section Abstract Doc Link 7496798 Disease Relevance 0.16 Pain Relevance 1.35
After acute subcutaneous administration, tramadol induced antinociception starting from a dose of 20 mg/kg, whereas it significantly enhanced natural killer activity and IL-2 production at doses as low as 1 mg/kg and splenocyte proliferation starting from a dose of 10 mg/kg.
Gene_expression (production) of IL-2 associated with antinociception and tramadol
20) Confidence 0.78 Published 1997 Journal Pain Section Abstract Doc Link 9313273 Disease Relevance 0.16 Pain Relevance 0.88

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