INT118078

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.50
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
neurons 1
cleavage 1
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 12 100.00 Very High Very High Very High
Eae 2 100.00 Very High Very High Very High
Morphine 1 86.16 High High
cytokine 6 84.56 Quite High
positron emission tomography 8 76.72 Quite High
cINOD 22 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 96.84 Very High Very High Very High
Neurodegenerative Disease 3 95.08 Very High Very High Very High
Amyloid Plaque 182 94.00 High High
Apoptosis 5 93.92 High High
Stress 90 91.96 High High
Drug Induced Neurotoxicity 20 85.72 High High
Cognitive Disorder 28 83.72 Quite High
Alzheimer's Dementia 201 75.00 Quite High
Toxicity 8 75.00 Quite High
Death 30 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that OSBP1 may modulate APP processing via complex mechanisms, perhaps by affecting both the non-amyloidogenic trafficking of APP and the clearance of sAPP?.
Phosphorylation (trafficking) of APP
1) Confidence 0.79 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
To determine whether Thr668 phosphorylation of APP accounts for H2O2-induced JNK-dependent promotion of ?
Phosphorylation (phosphorylation) of APP
2) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.13 Pain Relevance 0
It is possible that JNK phosphorylates APP and thereby makes it a better substrate for ?
Phosphorylation (phosphorylates) of APP
3) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.18 Pain Relevance 0.04
-secretase rather than Thr668 phosphorylation of APP.
Phosphorylation (phosphorylation) of APP
4) Confidence 0.79 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.09 Pain Relevance 0
These results suggest that OSBP1 may modulate APP processing via complex mechanisms, perhaps by affecting both the non-amyloidogenic trafficking of APP and the clearance of sAPP?.
Phosphorylation (trafficking) of sAPP
5) Confidence 0.69 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
More interestingly, PS1-D385TG significantly depressed the Notch S3-cleavage in releasing NICD, suggesting that the cleavage of APP at the ?
Phosphorylation (cleavage) of APP in cleavage
6) Confidence 0.67 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.06 Pain Relevance 0
Whether other phosphorylation sites of APP are involved has yet to be determined.
Phosphorylation (phosphorylation) of APP
7) Confidence 0.60 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.28 Pain Relevance 0.04
-secretase activation is likely independent of APP Thr668 phosphorylation.
Phosphorylation (phosphorylation) of APP
8) Confidence 0.60 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.23 Pain Relevance 0.04
Through a kinase-inhibiting effect (on GSK-3 and cdk5) it reduces phosphorylated APP, that gives rise to lower ?
Phosphorylation (phosphorylated) of APP
9) Confidence 0.18 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.79 Pain Relevance 0.04
While these inhibitors significantly attenuated Abeta peptide-triggered activation of caspase-2 and caspase-3, and AIP significantly decreased the degree of tau phosphorylation of the Abeta peptide-treated neurons at early time, they could elicit partial neuroprotection only.
Phosphorylation (phosphorylation) of Abeta in neurons associated with eae and abeta
10) Confidence 0.14 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15090032 Disease Relevance 0.74 Pain Relevance 0.61

General Comments

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