INT118095

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 9.69
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
ligaments 1
tendons 1
cartilage 1
skin 1
synovium 1
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 117 100.00 Very High Very High Very High
rheumatoid arthritis 39 100.00 Very High Very High Very High
psoriasis 95 99.80 Very High Very High Very High
Arthritis 268 99.28 Very High Very High Very High
Inflammation 44 97.72 Very High Very High Very High
imagery 20 81.04 Quite High
Pain 31 56.08 Quite High
cytokine 5 29.44 Quite Low
cINOD 5 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 112 100.00 Very High Very High Very High
Osteochondrodysplasias 46 100.00 Very High Very High Very High
Rheumatoid Arthritis 39 100.00 Very High Very High Very High
Rheumatic Diseases 30 100.00 Very High Very High Very High
Psoriasis 150 99.80 Very High Very High Very High
Experimental Arthritis 4 99.28 Very High Very High Very High
Arthritis 69 98.04 Very High Very High Very High
Seronegative Spondarthritis 205 96.68 Very High Very High Very High
Disease 84 96.44 Very High Very High Very High
Growth Problems 3 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand the effect of MED-causing mutations on the structure and function of matrilin-3 and thereby gain insight into the disease mechanisms of this form of MED, we expressed both normal and mutant full-length matrilin-3 proteins and single A-domains in mammalian cells.
Regulation (effect) of MED-causing associated with osteochondrodysplasias and disease
1) Confidence 0.43 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.83 Pain Relevance 0.04
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (considered) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
2) Confidence 0.39 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.47 Pain Relevance 0.61
Studies of experimental arthritis have been used to demonstrate that changes in serum levels of COMP reflect processes in cartilage [18,19].
Regulation (changes) of COMP in cartilage associated with experimental arthritis and arthritis
3) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.82 Pain Relevance 0.39
Role of TSP-5/COMP in pseudoachondroplasia.
Regulation (Role) of COMP
4) Confidence 0.26 Published 2004 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 15094116 Disease Relevance 0.28 Pain Relevance 0.05
OBJECTIVE: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo.
Spec (investigate) Regulation (changes) of COMP in urine associated with osteoarthritis
5) Confidence 0.25 Published 2010 Journal Osteoarthr. Cartil. Section Abstract Doc Link 19679221 Disease Relevance 0.17 Pain Relevance 0.09
We did not observe any changes of the baseline COMP levels over the 24-week period, thus there appears to be no long-term influence on the turnover of COMP induced by this physical exercise.
Neg (not) Regulation (changes) of COMP
6) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.09 Pain Relevance 0.04
The influence of physical exercise on serum COMP is not fully elucidated.
Regulation (influence) of COMP
7) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712338 Disease Relevance 0.37 Pain Relevance 0.19
We did not observe any changes of the baseline COMP levels over the 24-week period, thus there appears to be no long-term influence on the turnover of COMP induced by this physical exercise.
Neg (no) Spec (appears) Regulation (influence) of COMP
8) Confidence 0.24 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.08 Pain Relevance 0.04
As shown in Fig. 2, COMP mRNA (A and B) and protein (C and D) were markedly reduced by two shRNAs, 3A and 3B, that target different COMP type 3 calcium-repeat domain sequences (Fig. 1).
Regulation (target) of COMP
9) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.11 Pain Relevance 0
Skoumal et al13 couldnÂ’t find any evidence that extended skin lesions of psoriasis have any influence on serum COMP and thus its elevated levels were due to on going joint inflammation.
Regulation (influence) of serum COMP in skin associated with psoriasis, inflammation and arthritis
10) Confidence 0.24 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.61 Pain Relevance 0.46
Serum COMP was more sensitive while entheseal ultrasonography was more specific in the preclinical diagnosis of psoriatic arthritis, both had the same accuracy (Table 2).
Regulation (sensitive) of Serum COMP associated with seronegative spondarthritis and arthritis
11) Confidence 0.24 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 0.92 Pain Relevance 0.21
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (considered) of COMP in tendons associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
12) Confidence 0.13 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.47 Pain Relevance 0.61
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (considered) of COMP in synovium associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
13) Confidence 0.13 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.47 Pain Relevance 0.61

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