INT118098

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.76
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
cartilage 3
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 55 96.40 Very High Very High Very High
Pain 4 95.80 Very High Very High Very High
rheumatoid arthritis 73 93.04 High High
imagery 33 83.28 Quite High
Arthritis 9 47.68 Quite Low
cytokine 3 45.68 Quite Low
Inflammation 8 43.20 Quite Low
Rheumatism 2 12.96 Low Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 6 98.20 Very High Very High Very High
Frailty 3 96.40 Very High Very High Very High
Infection 6 95.36 Very High Very High Very High
Rheumatoid Arthritis 74 93.04 High High
Targeted Disruption 8 87.00 High High
Knee Osteoarthritis 43 82.32 Quite High
Stress 13 73.40 Quite High
Osteoarthritis 10 70.48 Quite High
Disease Progression 5 68.16 Quite High
Disease 25 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The type I collagen degradation marker ICTP (C-terminal telopeptide of type I collagen) and the cartilage markers CTX-II (C-terminal telopeptide fragments of type II collagen) and cartilage oligomeric matrix protein (COMP) were associated with the Larsen score at baseline.
Protein_catabolism (degradation) of COMP in cartilage
1) Confidence 0.66 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.60 Pain Relevance 0.19
The type I collagen degradation marker ICTP (C-terminal telopeptide of type I collagen) and the cartilage markers CTX-II (C-terminal telopeptide fragments of type II collagen) and cartilage oligomeric matrix protein (COMP) were associated with the Larsen score at baseline.
Protein_catabolism (degradation) of cartilage oligomeric matrix protein in cartilage
2) Confidence 0.58 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.60 Pain Relevance 0.19
The experiment was terminated after two weeks because COS-7 replication and viral degradation diluted the adenoviral COMP expression to very low levels.
Protein_catabolism (degradation) of COMP
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.67 Pain Relevance 0
Unlike other misfolded proteins that are targeted for degradation, much of the retained COMP escapes degradation, compromises cell function, and causes cell death.
Protein_catabolism (degradation) of COMP associated with death
4) Confidence 0.56 Published 2004 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 15094116 Disease Relevance 0.35 Pain Relevance 0.17
More specifically, we assessed the baseline levels of cartilage degradation, synthesis, and turnover products using collagenase-generated C1,2C, and C2C; Col II C-telopeptide (CTX-II assay); C-propeptide of type II collagen; aggrecan 846 epitope; and COMP in a sample of knees with known knee cartilage loss and controls.
Protein_catabolism (degradation) of COMP in cartilage
5) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.55 Pain Relevance 0.36

General Comments

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