INT118106

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.83
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1b) plasma membrane (Avpr1b) response to stress (Avpr1b)
signal transducer activity (Avpr1b)
Anatomy Link Frequency
pituitary 2
Avpr1b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 68 99.24 Very High Very High Very High
depression 38 95.68 Very High Very High Very High
Hyperalgesia 4 94.48 High High
agonist 36 90.92 High High
Pain 2 77.76 Quite High
Eae 4 71.44 Quite High
medulla 24 5.00 Very Low Very Low Very Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 12 97.88 Very High Very High Very High
Depression 46 95.68 Very High Very High Very High
Hyperalgesia 4 94.48 High High
Stress 322 93.64 High High
Affective Disorder 14 87.40 High High
Aggression 68 86.16 High High
Anxiety Disorder 32 80.36 Quite High
Pain 2 77.76 Quite High
Neurogenic Diabetes Insipidus 4 72.88 Quite High
Overactive Bladder 4 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of these modified Avp analogues display high selectivity for the Avpr1b and bind with sub-nanomolar affinities (Pena et al. 2007a) and thus could well be useful in the study of the Avp receptors in rodents; however, they may be of limited use as human therapeutics due to their peptidergic nature.
Avpr1b Binding (bind) of
1) Confidence 0.35 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.23 Pain Relevance 0.33
It has also been radiolabelled with tritium and used in receptor autoradiography to reveal low-resolution binding in the human and rat pituitary—no Avpr1b binding sites
Avpr1b Neg (no) Binding (binding) of in pituitary
2) Confidence 0.35 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.85 Pain Relevance 0.22
It has also been radiolabelled with tritium and used in receptor autoradiography to reveal low-resolution binding in the human and rat pituitary—no Avpr1b binding sites
Avpr1b Binding (binding) of in pituitary
3) Confidence 0.35 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.86 Pain Relevance 0.22
The compound acts at the human Avpr1b and also has some antagonist activity at the human Oxtr in vitro (Griffante et al. 2005) but has high selectivity and nanomolar affinity for rodent forms of the Avpr1b (Serradeil-Le Gal et al. 2002).
Avpr1b Binding (acts) of associated with antagonist
4) Confidence 0.31 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.81 Pain Relevance 0.32
In the Swedish sample, we observed significant allele (P=0.02) and genotype (P=0.01) association with SNP AVPR1b-s3, and in the Belgian sample, a borderline significant association with SNP AVPR1b-s5 (P=0.04).
AVPR1b Binding (association) of
5) Confidence 0.28 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15094789 Disease Relevance 0.55 Pain Relevance 0.20
In the Swedish sample, we observed significant allele (P=0.02) and genotype (P=0.01) association with SNP AVPR1b-s3, and in the Belgian sample, a borderline significant association with SNP AVPR1b-s5 (P=0.04).
AVPR1b Binding (association) of
6) Confidence 0.22 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15094789 Disease Relevance 0.53 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox