INT118114

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.52
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCG2) ATPase activity (ABCG2) plasma membrane (ABCG2)
transmembrane transport (ABCG2)
Anatomy Link Frequency
plasma 2
ABCG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 12 99.08 Very High Very High Very High
diclofenac 18 97.80 Very High Very High Very High
Cancer pain 2 94.08 High High
rheumatoid arthritis 2 92.44 High High
Perioperative pain 2 91.56 High High
Inflammation 2 88.96 High High
Analgesic 2 88.08 High High
opioid receptor 2 81.36 Quite High
Opioid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 2 100.00 Very High Very High Very High
Headache 12 99.08 Very High Very High Very High
Speech Disorder 2 94.72 High High
Cancer Pain 2 94.08 High High
Overactive Bladder 2 93.00 High High
Handedness 2 92.60 High High
Rheumatoid Arthritis 2 92.44 High High
Post Operative Pain 2 91.56 High High
INFLAMMATION 2 88.96 High High
Depression 2 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that loss of multidrug resistance protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ABCG2) in mice results in highly increased plasma levels of diclofenac acyl glucuronide, after both oral and intravenous administration.
Negative_regulation (loss) of ABCG2 in plasma associated with breast cancer and diclofenac
1) Confidence 0.57 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.63
Moreover, inhibition of ABCB1 and ABCG2 was investigated.
Negative_regulation (inhibition) of ABCG2
2) Confidence 0.50 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18516595 Disease Relevance 0 Pain Relevance 0.12
The correlation between the number of ABCP and the prevalence of migraine was 0.36 (P < 0.0001, confidence interval 0.26, 0.43).
Negative_regulation (number) of ABCP associated with migraine
3) Confidence 0.37 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15096222 Disease Relevance 0.79 Pain Relevance 0.51
The relationship between the number of ABCP and the prevalence of migraine was highly significant.
Negative_regulation (number) of ABCP associated with migraine
4) Confidence 0.37 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15096222 Disease Relevance 0.79 Pain Relevance 0.50
Inhibition assays demonstrated that tilidine and nortilidine can also inhibit CYP3A4, CYP2C19, CYP2D6, ABCB1, but not ABCG2, whereas inhibition of CYP2D6 and possibly also of CYP3A4 might be clinically relevant.
Negative_regulation (inhibit) of ABCG2
5) Confidence 0.32 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18516595 Disease Relevance 0 Pain Relevance 0.11
We show here that loss of multidrug resistance protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ABCG2) in mice results in highly increased plasma levels of diclofenac acyl glucuronide, after both oral and intravenous administration.
Negative_regulation (loss) of BCRP in plasma associated with breast cancer and diclofenac
6) Confidence 0.25 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.61

General Comments

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