INT118124

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 16.64
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (USE1) endoplasmic reticulum (USE1) lysosome (USE1)
Anatomy Link Frequency
plasma 1
blood 1
skin 1
ONJ 1
upper 1
USE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 185 100.00 Very High Very High Very High
cINOD 157 100.00 Very High Very High Very High
corticosteroid 36 100.00 Very High Very High Very High
antagonist 36 99.68 Very High Very High Very High
Morphine 48 99.44 Very High Very High Very High
Inflammation 118 98.44 Very High Very High Very High
cva 14 97.04 Very High Very High Very High
Adalimumab 162 96.16 Very High Very High Very High
tricyclic antidepressant 4 96.16 Very High Very High Very High
COX2 32 94.08 High High
Disease Link Frequency Relevance Heat
Osteoporosis 244 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 187 100.00 Very High Very High Very High
Lymphatic System Cancer 13 99.84 Very High Very High Very High
Aseptic Necrosis Of Bone 36 99.80 Very High Very High Very High
Pressure And Volume Under Development 25 99.76 Very High Very High Very High
Injury 105 99.56 Very High Very High Very High
Diarrhoea 55 99.56 Very High Very High Very High
Heart Rate Under Development 8 99.48 Very High Very High Very High
Pneumonia 3 99.48 Very High Very High Very High
Sleep Disorders 19 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 'off-label' use a licensed medicinal product is prescribed for an indication, or to a patient for which the product is not specifically licensed, whereas, in 'compassionate use' the medicinal product is not licensed and not used as a treatment for any disease.
use Binding (prescribed) of associated with disease
1) Confidence 0.16 Published 2010 Journal Trials Section Body Doc Link PMC2997627 Disease Relevance 0.36 Pain Relevance 0
The profile for cluster 5 “Most Here” shows extensive use of services at the agency doing the survey (the peak is 9 which is “Case management”) and low use of services at other agencies.Fig. 1Percentage service utilization by cluster
low use Binding (1Percentage) of
2) Confidence 0.16 Published 2008 Journal AIDS Behav Section Body Doc Link PMC2834767 Disease Relevance 0.64 Pain Relevance 0
Patients who have a history of good response to oral olanzapine and are in need of assured medication administration may present a good indication for its use, provided that the appropriate mental health delivery setting is available.



use Binding (indication) of associated with mental disorders
3) Confidence 0.11 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2898165 Disease Relevance 0.62 Pain Relevance 0
The European Commission has authorized its use and it is commercially available in several countries in Europe and Japan where it is marketed for the treatment of STS in adults after failure of standard therapy.
use Binding (authorized) of associated with sarcoma
4) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899778 Disease Relevance 0.71 Pain Relevance 0
Besides an elevated CV risk, it has recently been shown that the use of conventional NSAIDs is associated with edema, congestive heart failure, cardiac arrhythmias, and an increased risk of CV events (Kearney et al 2006; McGettigan and Henry 2006; Vonkemann et al 2006; Zhang et al 2006).
use Binding (associated) of in heart associated with heart rate under development, pressure and volume under development and cinod
5) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504080 Disease Relevance 1.01 Pain Relevance 0.33
ESA use was associated with a mean difference of 1.05 units of blood transfused.
use Binding (associated) of in blood
6) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.32 Pain Relevance 0
The most reliable method for determining whether ONJ is associated with the use of bisphosphonates would be through prospective trials in which the incidence of ONJ in patients receiving bisphosphonates vs patients not receiving bisphosphonates would be compared and where all other health parameters are essentially equal.
use Spec (whether) Binding (associated) of
7) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909499 Disease Relevance 0.72 Pain Relevance 0
Case–control studies have been undertaken to assess the association between AF and bisphosphonate use.
use Binding (association) of associated with arrhythmias 2 under development
8) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909499 Disease Relevance 1.08 Pain Relevance 0
A possible association between bisphosphonate use and osteonecrosis of the jaw (ONJ) has also been suggested.
use Binding (association) of in ONJ associated with aseptic necrosis of bone
9) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2909499 Disease Relevance 0.57 Pain Relevance 0
The safety profile of ESAs remains a highly contentious issue.44,45 In the presence of accumulating data indicating potential harm, regulatory authorities have increasingly restricted approved indications for ESA use.
use Binding (indications) of
10) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.70 Pain Relevance 0.24
In addition, a variety of other biologic interventions, such as sleep deprivation and bright light therapy, may be of use in certain patient subgroups.
use Binding (be) of associated with sleep disorders
11) Confidence 0.06 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.73 Pain Relevance 0.63
The study further demonstrated that alendronate use was not associated with a significant increase in upper GI tract events among patients at increased risk of those events (age 75 years or older, with previous upper GI disease, or using nonsteroidal anti-inflammatory drugs [NSAIDs]).69
use Binding (associated) of in upper associated with inflammation, cinod and disease
12) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909499 Disease Relevance 0.19 Pain Relevance 0.19
Since 2003, there have been a flurry of case reports and case series suggesting that bisphosphonate use may be associated with a condition called ONJ, which has many apparent similarities to osteomyelitis.
use Binding (associated) of associated with osteomyelitis
13) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909499 Disease Relevance 0.88 Pain Relevance 0
There is some speculation that lymphomas may be associated with the use of TNF antagonists (Geborek et al 2005).
use Binding (associated) of associated with lymphatic system cancer and antagonist
14) Confidence 0.04 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 1.58 Pain Relevance 0.78
Indeed, recent systematic reviews of published and unpublished cases indicate that the use of bisphosphonates for osteoporosis is associated with an ONJ incidence of less than 1 in 100,000 patient-years of exposure,111,112 but the background rate of occurrence for comparison is unknown.
use Binding (associated) of associated with osteoporosis
15) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909499 Disease Relevance 0.81 Pain Relevance 0
C1-INH functional assays may use chromogenic or C1s binding ELISA assays.
use Binding (binding) of
16) Confidence 0.03 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921362 Disease Relevance 0.24 Pain Relevance 0
Roflumilast is not related to an increased risk of pneumonia or other adverse affects associated with ICSs use, such as osteoporosis, glaucoma, cataracts, and skin thinning.
use Binding (associated) of in skin associated with corticosteroid, atrophic skin disease, glaucoma, osteoporosis, pneumonia and cataract
17) Confidence 0.03 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915539 Disease Relevance 0.78 Pain Relevance 0.09
Munc18 blocks syntaxin interactions with cognate SNARE proteins and thereby act as an inhibitor of exocytosis.
SNARE Binding (interactions) of
18) Confidence 0.03 Published 2004 Journal Pancreas Section Abstract Doc Link 15097857 Disease Relevance 0.15 Pain Relevance 0.07
Diarrhea is an anticipated AE associated with tegaserod use, given its promotile activity in the GI tract.
use Binding (associated) of associated with diarrhoea
19) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936292 Disease Relevance 0.79 Pain Relevance 0.52
Although corticosteroids can suppress active inflammation in the acute setting, they are ineffective maintenance agents, and long-term use is associated with important side effects (such as osteoporosis, hypertension, diabetes mellitus, and ocular complications) and high relapse rates, often complicated by the occurrence of steroid dependency or refractoriness.
use Binding (associated) of associated with corticosteroid, inflammation, diabetes mellitus, hypertension, osteoporosis and recurrence
20) Confidence 0.02 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012434 Disease Relevance 1.12 Pain Relevance 0.42

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