INT118130

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.08
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink3)
Anatomy Link Frequency
gland 1
Spink3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 13 86.52 High High
Chronic pancreatitis 103 84.28 Quite High
fibrosis 14 81.68 Quite High
cytokine 9 45.24 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Pain management 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 50 100.00 Very High Very High Very High
Injury 7 99.60 Very High Very High Very High
Death 3 96.28 Very High Very High Very High
Pancreatitis 168 92.88 High High
INFLAMMATION 12 87.24 High High
Fibrosis 2 81.68 Quite High
Disease 30 79.52 Quite High
Apoptosis 8 27.28 Quite Low
Pancreatic Cancer 16 5.00 Very Low Very Low Very Low
Cystic Fibrosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because SPINK3 may be an important serine protease inhibitor, its up-regulation may reflect an important endogenous cytoprotective mechanism in preventing further injury.
Negative_regulation (inhibitor) of SPINK3 associated with injury
1) Confidence 0.42 Published 2004 Journal Pancreas Section Abstract Doc Link 15097871 Disease Relevance 0.51 Pain Relevance 0.13
Therefore, these data indicate that the total loss of SPINK3 function leads to a strong imbalance in favour of trypsin activity resulting in acinar cell death and involution of the whole gland and finally leading to the lethal phenotype.
Negative_regulation (loss) of SPINK3 in gland associated with death
2) Confidence 0.26 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.81 Pain Relevance 0.04
The other study showed that targeted disruption of the mouse homologue of human SPINK1, murine SPINK3, is lethal at day 14,5 after birth [31].
Negative_regulation (disruption) of SPINK3 associated with targeted disruption
3) Confidence 0.24 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.76 Pain Relevance 0

General Comments

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