INT118130

Context Info Confidence 0.42 First Reported 2004 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.08 Pain Relevance 0.17

extracellular region (Spink3)

Anatomy Link Frequency gland 1 Spink3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 13 86.52 Chronic pancreatitis 103 84.28 fibrosis 14 81.68 cytokine 9 45.24 Pain 6 5.00 Bile 6 5.00 Pain management 3 5.00 alcohol 3 5.00 imagery 3 5.00 abdominal pain 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 50 100.00 Injury 7 99.60 Death 3 96.28 Pancreatitis 168 92.88 INFLAMMATION 12 87.24 Fibrosis 2 81.68 Disease 30 79.52 Apoptosis 8 27.28 Pancreatic Cancer 16 5.00 Cystic Fibrosis 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because SPINK3 may be an important serine protease inhibitor, its up-regulation may reflect an important endogenous cytoprotective mechanism in preventing further injury.

Negative_regulation (inhibitor) of SPINK3 associated with injury

1) Confidence 0.42 Published 2004 Journal Pancreas Section Abstract Doc Link 15097871 Disease Relevance 0.51 Pain Relevance 0.13

Therefore, these data indicate that the total loss of SPINK3 function leads to a strong imbalance in favour of trypsin activity resulting in acinar cell death and involution of the whole gland and finally leading to the lethal phenotype.

Negative_regulation (loss) of SPINK3 in gland associated with death

2) Confidence 0.26 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.81 Pain Relevance 0.04

The other study showed that targeted disruption of the mouse homologue of human SPINK1, murine SPINK3, is lethal at day 14,5 after birth [31].

Negative_regulation (disruption) of SPINK3 associated with targeted disruption

3) Confidence 0.24 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.76 Pain Relevance 0

General Comments

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