INT118131

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Context Info
Confidence 0.07
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.92
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1s) extracellular region (C1s)
Anatomy Link Frequency
neuronal 2
C1s (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 138 99.68 Very High Very High Very High
Chronic pancreatitis 97 98.88 Very High Very High Very High
cINOD 1 98.52 Very High Very High Very High
fibrosis 14 80.60 Quite High
Somatostatin 17 79.20 Quite High
Pain 6 26.60 Quite Low
Inflammation 16 8.44 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Bile 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 124 98.88 Very High Very High Very High
Injury 10 98.52 Very High Very High Very High
INFLAMMATION 18 98.32 Very High Very High Very High
Viral Infection 4 94.04 High High
Pancreatic Cancer 16 92.96 High High
Nicotine Addiction 3 90.64 High High
Infection 38 89.04 High High
Dengue 5 88.36 High High
Flavivirus Infection 8 87.48 High High
Body Weight 12 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because SPINK3 may be an important serine protease inhibitor, its up-regulation may reflect an important endogenous cytoprotective mechanism in preventing further injury.
Negative_regulation (inhibitor) of serine protease associated with injury
1) Confidence 0.07 Published 2004 Journal Pancreas Section Abstract Doc Link 15097871 Disease Relevance 0.51 Pain Relevance 0.12
The serine protease inhibitor PCI (SERPINA5) has initially been described in humans to be involved in the regulation of hemostasis and fibrinolysis (Ecke et al. 1992; Espana et al. 1989; Geiger et al. 1989; Marlar and Griffin 1980; Meijers et al. 1988; Suzuki et al. 1983).
Negative_regulation (inhibitor) of serine protease
2) Confidence 0.06 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0 Pain Relevance 0
This molecule inhibits C1r, C1s, C3 convertase, C5 convertase, and FD (Fujii and Hitomi 1981; Inagi et al 1991).
Negative_regulation (inhibits) of C1s
3) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
Human recombinant TIMP-1 (Calbiochem, San Diego, CA) and TIMP-2 (R&D Systems) were used for MMP inhibition and serine protease inhibitors leupeptin and epsilon-amino-caproic acid (EACA) were obtained from Sigma (St Louis, MO).
Negative_regulation (inhibitors) of serine protease associated with metalloproteinase
4) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.23 Pain Relevance 0.24
For instance, there are several reports describing the in vitro inhibitory effect of compounds such as ribavirin, mycophenolic acid, imino sugars, inhibitors of serine protease, RNA interference and non-steroidal anti-inflammatory drugs against flaviviruses [8-13].
Negative_regulation (inhibitors) of serine protease associated with inflammation and cinod
5) Confidence 0.05 Published 2008 Journal Virol J Section Body Doc Link PMC2408923 Disease Relevance 0.86 Pain Relevance 0.10
53%; Figure 4D; serine protease inhibitor Spi2.1, ?
Negative_regulation (inhibitor) of serine protease
6) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.10
This staining pattern, along with our data on PN-1's effect on migration, strengthens our hypothesis that this serine protease inhibitor plays a role in neuronal migration.
Negative_regulation (inhibitor) of serine protease in neuronal
7) Confidence 0.03 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
Affigel blue beads were used to deliver a serine protease inhibitor, protease nexin-1 (PN-1), and a target protease, trypsin, to the olfactory epithelium coincident with initiation of GnRH neuronal migration.
Negative_regulation (inhibitor) of serine protease in neuronal
8) Confidence 0.03 Published 2002 Journal BMC Dev Biol Section Abstract Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
Other serine protease inhibitors tested included: soybean trypsin inhibitor and Type IV chicken ovoinhibitor (data not shown).
Negative_regulation (inhibitors) of serine protease
9) Confidence 0.03 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.06 Pain Relevance 0
Witt and colleagues described at first an association between mutations of the serine protease inhibitor, Kazal type 1 (SPINK1) and chronic pancreatitis [14].
Negative_regulation (inhibitor) of serine protease associated with chronic pancreatitis
10) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.26 Pain Relevance 0.58

General Comments

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