INT118150

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prkcz) nuclear envelope (Prkcz) protein complex (Prkcz)
cytoplasm (Prkcz) cytosol (Prkcz) signal transduction (Prkcz)
Anatomy Link Frequency
sciatic nerve 2
Prkcz (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 100.00 Very High Very High Very High
Morphine 6 98.88 Very High Very High Very High
Sciatic nerve 9 98.48 Very High Very High Very High
Neuropathic pain 4 97.20 Very High Very High Very High
Thermal hyperalgesia 1 78.68 Quite High
Lasting pain 1 76.64 Quite High
Kinase C 7 75.00 Quite High
intrathecal 1 57.40 Quite High
neuralgia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 97.20 Very High Very High Very High
Hyperalgesia 1 78.68 Quite High
Syndrome 1 77.20 Quite High
Pain 1 76.64 Quite High
Nervous System Injury 1 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that activation of PKCs, including cPKC and PKCzeta, within the spinal cord is directly responsible for the attenuation of the morphine-induced rewarding effect under a neuropathic pain-like state following sciatic nerve ligation in mice.
Spec (like) Positive_regulation (responsible) of Positive_regulation (activation) of PKCzeta in sciatic nerve associated with neuropathic pain, sciatic nerve, morphine and spinal cord
1) Confidence 0.08 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.49 Pain Relevance 1.42

General Comments

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