INT118151

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.35
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prkcz) nuclear envelope (Prkcz) protein complex (Prkcz)
cytoplasm (Prkcz) cytosol (Prkcz) signal transduction (Prkcz)
Anatomy Link Frequency
sciatic nerve 2
spinal cord 2
spinal 1
Prkcz (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 33 100.00 Very High Very High Very High
Spinal cord 17 100.00 Very High Very High Very High
Sciatic nerve 36 99.72 Very High Very High Very High
Pain 6 98.52 Very High Very High Very High
Neuropathic pain 16 97.08 Very High Very High Very High
Morphine 24 96.96 Very High Very High Very High
Thermal hyperalgesia 4 96.68 Very High Very High Very High
Lasting pain 4 94.64 High High
intrathecal 7 91.12 High High
withdrawal 1 70.96 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 4 99.86 Very High Very High Very High
Pain 8 98.52 Very High Very High Very High
Neuropathic Pain 16 97.08 Very High Very High Very High
Hyperalgesia 4 96.68 Very High Very High Very High
Syndrome 4 95.20 Very High Very High Very High
Nociception 1 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data provide direct evidence that activated cPKC and PKCzeta in the spinal cord may contribute to the development and maintenance of neuropathic pain.
Positive_regulation (activated) of PKCzeta in spinal cord associated with neuropathic pain and spinal cord
1) Confidence 0.12 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.58 Pain Relevance 1.66
We found here that the activities of both cPKC and PKCzeta in the spinal cord were clearly increased following sciatic nerve ligation.
Positive_regulation (increased) of PKCzeta in sciatic nerve associated with sciatic nerve and spinal cord
2) Confidence 0.09 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.57 Pain Relevance 1.50
These results suggest that activation of PKCs, including cPKC and PKCzeta, within the spinal cord is directly responsible for the attenuation of the morphine-induced rewarding effect under a neuropathic pain-like state following sciatic nerve ligation in mice.
Positive_regulation (activation) of PKCzeta in sciatic nerve associated with neuropathic pain, sciatic nerve, morphine and spinal cord
3) Confidence 0.08 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.49 Pain Relevance 1.42
Here we first investigated whether sciatic nerve injury could change the activity of a conventional PKC (cPKC) and an atypical PKC isoform PKCzeta in the mouse spinal cord.
Positive_regulation (change) of PKCzeta in spinal cord associated with kinase c, nervous system injury, sciatic nerve and spinal cord
4) Confidence 0.07 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.37 Pain Relevance 1.12
Conversely, the sigma-1 receptor activation of the PKCzeta isoform appears to be involved in a pain signaling pathway that is independent of spinal pNR1 modulation.
Positive_regulation (activation) of PKCzeta in spinal associated with pain
5) Confidence 0.04 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.34 Pain Relevance 0.71

General Comments

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