INT118153

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.15
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
sensory neurons 2
sciatic nerve 2
skeletal muscle 1
peripheral nerve 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 121 100.00 Very High Very High Very High
Spinal cord 5 100.00 Very High Very High Very High
Inflammatory mediators 9 99.98 Very High Very High Very High
nociceptor 48 99.60 Very High Very High Very High
Morphine 6 98.88 Very High Very High Very High
Sciatic nerve 9 98.48 Very High Very High Very High
Neuropathic pain 5 97.20 Very High Very High Very High
substance P 15 96.64 Very High Very High Very High
Inflammation 61 94.08 High High
Pain 21 89.84 High High
Disease Link Frequency Relevance Heat
Infection 20 99.80 Very High Very High Very High
INFLAMMATION 66 99.78 Very High Very High Very High
Virus Diseases 94 99.60 Very High Very High Very High
Disease 105 98.88 Very High Very High Very High
Neuropathic Pain 6 97.20 Very High Very High Very High
Pressure And Volume Under Development 3 91.64 High High
Pain 23 89.84 High High
Hyperlipidemia 6 88.96 High High
Coagulation Disorder 7 82.56 Quite High
Hyperalgesia 12 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that activation of PKCs, including cPKC and PKCzeta, within the spinal cord is directly responsible for the attenuation of the morphine-induced rewarding effect under a neuropathic pain-like state following sciatic nerve ligation in mice.
Regulation (responsible) of Positive_regulation (activation) of cPKC in sciatic nerve associated with neuropathic pain, sciatic nerve, morphine and spinal cord
1) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.49 Pain Relevance 1.42
Thus, BDV infection does not alter the ability of PKC to be activated.
Neg (not) Regulation (alter) of Positive_regulation (activated) of PKC associated with virus diseases, kinase c and infection
2) Confidence 0.21 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 1.00 Pain Relevance 0.69
On the other hand, activation of PKC has regulatory effects on skeletal muscle Na+ channels [25], brain Na+ channels [26] and peripheral nerve Na+ channel expressed in Xenopus oocytes [27].
Regulation (effects) of in peripheral nerve Positive_regulation (activation) of PKC in skeletal muscle
3) Confidence 0.21 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.06
Many pro-inflammatory mediators sensitize TRPV1 via downstream activation of PKC?
Regulation (sensitize) of Positive_regulation (activation) of PKC associated with inflammatory mediators
4) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.10 Pain Relevance 0.28
In order to determine whether intracellular calcium or PKC activation mediate the observed cross-talk, the cells were incubated with specific IP3R blocker (2-APB; 40 ?
Spec (whether) Regulation (calcium) of Spec (whether) Positive_regulation (activation) of PKC associated with kinase c
5) Confidence 0.10 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.25
These pathways also affect the activities of kinases such as PKC, GSK-3?
Regulation (affect) of Positive_regulation (activities) of PKC associated with kinase c
6) Confidence 0.08 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.52 Pain Relevance 0.08
To the best of our knowledge no studies have investigated the localization of functional PAR1, 3 and 4 receptors in sensory neurons, nor the role of receptors activated by thrombin in TRPV1 sensitisation or in activation of PKC?
Neg (nor) Spec (investigated) Regulation (role) of Positive_regulation (activation) of PKC in sensory neurons
7) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.52 Pain Relevance 0.27
Sensitization of TRPV1 depends on activation of the epsilon isoform of PKC (PKC?)
Regulation (depends) of Positive_regulation (activation) of PKC
8) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.51 Pain Relevance 0.18

General Comments

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