INT118154

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.58
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
sciatic nerve 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 85 100.00 Very High Very High Very High
Sciatic nerve 9 100.00 Very High Very High Very High
Spinal cord 8 100.00 Very High Very High Very High
Morphine 160 99.98 Very High Very High Very High
opioid receptor 168 99.28 Very High Very High Very High
Lasting pain 5 94.80 High High
tolerance 56 93.00 High High
Thermal hyperalgesia 1 91.36 High High
intrathecal 1 87.48 High High
Analgesic 38 82.80 Quite High
Disease Link Frequency Relevance Heat
Pain 7 94.16 High High
Syndrome 1 93.36 High High
Hyperalgesia 1 91.36 High High
Nervous System Injury 1 78.96 Quite High
Neuropathic Pain 4 75.20 Quite High
Urological Neuroanatomy 36 12.04 Low Low
Nociception 14 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Intractable Pain 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found here that the activities of both cPKC and PKCzeta in the spinal cord were clearly increased following sciatic nerve ligation.
Positive_regulation (increased) of cPKC Binding (ligation) of in sciatic nerve associated with sciatic nerve and spinal cord
1) Confidence 0.50 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099668 Disease Relevance 0.58 Pain Relevance 1.54
NMDAR-permeated zinc takes control over the recruitment of PKC?
Positive_regulation (takes) of PKC Binding (recruitment) of associated with kinase c
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.75
In agreement with previous reports, ex vivo assays showed the following after a morphine challenge: the presence of MORs in the membrane surface remained constant, morphine increased the recruitment of PKC?
Positive_regulation (increased) of PKC Binding (recruitment) of associated with kinase c and morphine
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.52

General Comments

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