INT118177

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 10
Disease Relevance 0.79
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv5) transmembrane transport (Trpv5)
Trpv5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
member 8 10 100.00 Very High Very High Very High
Kinase C 5 98.48 Very High Very High Very High
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 80 89.52 High High
Targeted Disruption 20 87.12 High High
Apoptosis 5 49.84 Quite Low
Body Weight 20 9.64 Low Low
Volume Depletion And Dehydration 10 5.00 Very Low Very Low Very Low
Hematuria 5 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Weight Gain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several previous reports described the regulation of TRPV5 and TRPV6 by vitamin D3 (15, 17-20) and estrogen (17, 21).
Regulation (regulation) of TRPV5
1) Confidence 0.60 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.32 Pain Relevance 0
80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).
Regulation (regulating) of transient receptor potential cation channel V5 associated with member 8
2) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.24
80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).
Regulation (regulating) of TRPV5 associated with member 8
3) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.24
By the use of cDNA microarrays, the present study identified 80K-H as the first protein involved in the Ca(2+)-dependent control of the epithelial Ca(2+) channel TRPV5. 80K-H was initially identified as a protein kinase C substrate, but its biological function remains to be established.
Regulation (control) of TRPV5 associated with kinase c
4) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.20
Ca(2+) influx through TRPV5 is tightly controlled by modulators of Ca(2+) homeostasis, including 1,25-dihydroxyvitamin D(3) and dietary Ca(2+).
Regulation (controlled) of TRPV5
5) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.20
In conclusion, we report a novel function for 80K-H as a Ca(2+) sensor controlling TRPV5 channel activity.
Regulation (controlling) of TRPV5
6) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.10
Therefore, the administration of high dose vitamin D3 seems to attenuate the hypocalciuric effect of HCTZ by inducing persistent down-regulation of TRPV5.
Regulation (regulation) of TRPV5
7) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0 Pain Relevance 0
However, in the high Ca-vitamin D with HCTZ group, HCTZ decreased urinary calcium excretion by 15% compared to the high Ca-vitamin D group and did not affect the protein abundance of TRPV5.
Neg (not) Regulation (affect) of TRPV5
8) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.07 Pain Relevance 0
Hoenderop et al. reported that TRPV5 is an important target of active vitamin D3 and is positively controlled by vitamin D3 through experiments using vitamin D-deficient diet (15) and 25-hydroxyvitamin D3-1?
Regulation (target) of TRPV5
9) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.33 Pain Relevance 0
TRPV5 protein abundance was not changed by HCTZ in the high calcium-vitamin D with HCTZ group compared to the high calcium-vitamin D group.
Neg (not) Regulation (changed) of TRPV5 protein
10) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923802 Disease Relevance 0.08 Pain Relevance 0

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