INT118183

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.99
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv5) transmembrane transport (Trpv5)
Anatomy Link Frequency
plasma 1
kidney 1
Trpv5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 95.04 Very High Very High Very High
qutenza 1 87.44 High High
TRP channel 6 83.24 Quite High
member 8 4 75.00 Quite High
agonist 7 22.44 Low Low
Glutamate receptor 3 18.28 Low Low
Glutamate 1 8.96 Low Low
Central nervous system 8 7.68 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 64 99.54 Very High Very High Very High
Targeted Disruption 20 95.92 Very High Very High Very High
Volume Depletion And Dehydration 8 81.28 Quite High
Weight Gain 4 77.76 Quite High
Apoptosis 4 59.40 Quite High
Body Weight 16 28.36 Quite Low
Cystic Fibrosis 8 5.00 Very Low Very Low Very Low
Hematuria 4 5.00 Very Low Very Low Very Low
Hypercalcemia 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we demonstrated that concomitant administration of high calcium diet and high dose vitamin D3 induces severe hypercalciuria by decreasing protein abundance of TRPV5 and major sodium transporters participating in passive calcium reabsorption.
Localization (abundance) of TRPV5 associated with kidney stones
1) Confidence 0.73 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.10 Pain Relevance 0
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Localization (abundance) of TRPV5 associated with kidney stones
2) Confidence 0.73 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.18 Pain Relevance 0
Our current data showed that HCTZ did not affect protein abundance of TRPV5 in high calcium diet and vitamin D-induced severe hypercalciuric rats, resulting in small reduction of urinary calcium excretion.
Localization (abundance) of TRPV5
3) Confidence 0.73 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.38 Pain Relevance 0
Hoenderop et al. reported that TRPV5 is an important target of active vitamin D3 and is positively controlled by vitamin D3 through experiments using vitamin D-deficient diet (15) and 25-hydroxyvitamin D3-1?
Localization (target) of TRPV5
4) Confidence 0.73 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.33 Pain Relevance 0
None of the 80K-H mutants altered the TRPV5 plasma membrane localization nor the association of 80K-H with TRPV5, suggesting that 80K-H has a direct effect on TRPV5 activity.
Localization (localization) of TRPV5 in plasma
5) Confidence 0.70 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.11
We demonstrated a specific interaction between 80K-H and TRPV5, co-localization of both proteins in the kidney, and similar transcriptional regulation by 1,25-dihydroxyvitamin D(3) and dietary Ca(2+).
Localization (co-localization) of TRPV5 in kidney
6) Confidence 0.70 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.19
TRPV5 and TRPV6, however, are selective for Ca2+ against monovalent cations, whereas TRPM4 and TRPM5 are selective for monovalent cations.
Localization (selective) of TRPV5
7) Confidence 0.22 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.17

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