INT118184

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.23
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv5) transmembrane transport (Trpv5)
Anatomy Link Frequency
plasma 1
Trpv5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
member 8 3 99.34 Very High Very High Very High
Kinase C 1 66.08 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 99.88 Very High Very High Very High
Kidney Stones 64 95.80 Very High Very High Very High
Osteoporosis 2 78.64 Quite High
Volume Depletion And Dehydration 8 73.20 Quite High
Weight Gain 4 69.68 Quite High
Apoptosis 4 63.24 Quite High
Hypercalcemia 4 61.60 Quite High
Hematuria 4 60.48 Quite High
Body Weight 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the 80K-H mutants altered the TRPV5 plasma membrane localization nor the association of 80K-H with TRPV5, suggesting that 80K-H has a direct effect on TRPV5 activity.
Neg (nor) Negative_regulation (altered) of TRPV5 in plasma
1) Confidence 0.43 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.11
Therefore, the administration of high dose vitamin D3 seems to attenuate the hypocalciuric effect of HCTZ by inducing persistent down-regulation of TRPV5.
Negative_regulation (regulation) of TRPV5
2) Confidence 0.42 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0 Pain Relevance 0
We previously reported that the down-regulation of transient receptor potential vanilloid 5 (TRPV5), sodium-hydrogen exchanger 3 (NHE3), sodium-glucose cotransporter 1 (SGLT1), and sodium-potassium-chloride cotransporter type 2 (NKCC2) is associated with hypercalciuria and that thiazides decreased calcium excretion by 50% in hypercalciuric rats induced by high salt or high calcium diet (12).
Negative_regulation (regulation) of TRPV5 associated with kidney stones
3) Confidence 0.42 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.62 Pain Relevance 0
We also revealed that the hypocalciuric effect of HCTZ is attenuated in high calcium diet and vitamin D-induced hypercalciuric rats, probably caused by persistently decreased TRPV5 protein abundance.
Negative_regulation (decreased) of TRPV5 protein
4) Confidence 0.42 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.09 Pain Relevance 0
There were also a report demonstrating the essential role of TRPV5 in calcium homeostasis using TRPV5-null mice (27), and another report showing that the gatekeeper function of TRPV5 is the rate-limiting step in active calcium reabsorption using single- and double-knockout mice lacking TRPV5 and calbindin-D28K (28).
Negative_regulation (lacking) of TRPV5 associated with targeted disruption
5) Confidence 0.42 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.38 Pain Relevance 0
The mRNA levels of renal 25-hydoxyvitamin D 24-hydroxylase (24OHase) increased, whereas those of renal 25-hydroxyvitamin D 1-alpha hydroxylase (1alpha-hydroxylase), duodenal transient receptor potential cation channel, subfamily V, member 6 (TRPV6), TRPV5, and calbindin-D9k were all decreased.
Negative_regulation (decreased) of TRPV5 associated with member 8
6) Confidence 0.42 Published 2006 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16816923 Disease Relevance 0.14 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox