INT118206

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.85
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TP53INP2)
Anatomy Link Frequency
peripheral nerve 4
TP53INP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 13 100.00 Very High Very High Very High
Delta opioid receptors 3 100.00 Very High Very High Very High
Endogenous opioid 1 99.84 Very High Very High Very High
Opioid 8 99.56 Very High Very High Very High
Peripheral nerve injury 10 99.52 Very High Very High Very High
Eae 4 98.84 Very High Very High Very High
Enkephalin 8 98.60 Very High Very High Very High
Sciatic nerve 4 97.56 Very High Very High Very High
Neuropathic pain 4 96.52 Very High Very High Very High
tolerance 1 92.48 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 14 99.08 Very High Very High Very High
Injury 2 96.72 Very High Very High Very High
Neuropathic Pain 4 96.52 Very High Very High Very High
Pain 6 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that decreases in the expression of DOR are a common feature of peripheral nerve injury.
Negative_regulation (decreases) of Gene_expression (expression) of DOR in peripheral nerve associated with nervous system injury, opioid receptor and peripheral nerve injury
1) Confidence 0.29 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135930 Disease Relevance 0.96 Pain Relevance 1.16
Reduced expression of delta-opioid receptors (DOR) following peripheral nerve injury has been reported but most of these reports are limited to subjective observation.
Negative_regulation (Reduced) of Gene_expression (expression) of DOR in peripheral nerve associated with nervous system injury, opioid receptor, delta opioid receptors and peripheral nerve injury
2) Confidence 0.25 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135930 Disease Relevance 0.89 Pain Relevance 1.47
In the present study, we examined desensitization of the human delta-opioid receptor (hDOR) produced by endogenous opioid peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), and the contribution of internalization in this process.
Spec (examined) Negative_regulation (desensitization) of Gene_expression (produced) of hDOR associated with endogenous opioid, enkephalin and opioid receptor
3) Confidence 0.02 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.76

General Comments

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