INT118207

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 11
Total Number 23
Disease Relevance 7.39
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
blood 3
stomach 2
hypothalamus 1
plasma 1
lateral 1
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 2 100.00 Very High Very High Very High
agonist 231 99.84 Very High Very High Very High
Opioid 3 99.28 Very High Very High Very High
Action potential 2 97.92 Very High Very High Very High
antinociception 1 97.60 Very High Very High Very High
Eae 42 95.48 Very High Very High Very High
narcan 3 95.12 Very High Very High Very High
antagonist 251 94.72 High High
alcohol 14 93.48 High High
Potency 12 93.48 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 100.00 Very High Very High Very High
Aging 39 99.20 Very High Very High Very High
Death 12 98.60 Very High Very High Very High
Appetite Loss 176 98.54 Very High Very High Very High
Repression 72 94.68 High High
Stress 149 94.60 High High
Diabetes Mellitus 73 93.76 High High
Increased Venous Pressure Under Development 48 91.36 High High
Gastric Motility Disorder 22 90.96 High High
Hyperalgesia 6 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall these data indicate that ghrelin exerts an inhibitory role on inflammatory pain through an interaction with the central opioid system.
ghrelin Binding (interaction) of associated with ipn and opioid
1) Confidence 0.47 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16759671 Disease Relevance 0.82 Pain Relevance 0.95
Ghrelin, a 28 amino acids polypeptide was recognized as an endogenous ligand for the growth hormone secretagogue receptor.
Ghrelin Binding (recognized) of
2) Confidence 0.47 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17229991 Disease Relevance 0.05 Pain Relevance 0
GHS receptor type 1b arises from a nonspliced transcript, whose product does not bind acylghrelin or confer known bioactivity [5, 187].
ghrelin Neg (not) Binding (bind) of
3) Confidence 0.36 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.90 Pain Relevance 0.16
An endogenous ligand for the GHS receptor, acylghrelin, was identified in 1999.
ghrelin Binding (ligand) of
4) Confidence 0.35 Published 2010 Journal International Journal of Peptides Section Abstract Doc Link PMC2925380 Disease Relevance 0.11 Pain Relevance 0
The data indicated that aging-associated anorexia is caused by an increase in plasma leptin, which results from disturbed reactivity of ghrelin in the hypothalamus and regulation of ghrelin secretion.
ghrelin Binding (reactivity) of in hypothalamus associated with appetite loss and aging
5) Confidence 0.35 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915625 Disease Relevance 0.82 Pain Relevance 0.15
Analysis of interactions between ghrelin and other systems involved in the control of PRL secretion revealed that neither blockade of dopaminergic receptors with domperidone, nor enhancement of serotoninergic tone with fluoxetine + 5-hydroxytryptophan altered the inhibitory response to ghrelin in terms of PRL secretion.
ghrelin Binding (interactions) of associated with fluoxetine
6) Confidence 0.33 Published 2004 Journal Neuroendocrinology Section Abstract Doc Link 15103226 Disease Relevance 0 Pain Relevance 0.28
Alternatively, ghrelin might indirectly engage the orexin system by targeting neurons at other locations which, in turn, project to the lateral hypothalamic area.
ghrelin Spec (might) Binding (engage) of in neurons
7) Confidence 0.28 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915752 Disease Relevance 0.11 Pain Relevance 0.29
Obestatin was initially reported to be endogenous ligand for orphan G protein-coupled receptor GPR39 [2]; however recent studies have found no specific binding of obestatin to various types of GPR39-expressing cells [3–5].
Obestatin Binding (ligand) of
8) Confidence 0.24 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0
Obestatin was initially reported to be endogenous ligand for orphan G protein-coupled receptor GPR39 [2]; however recent studies have found no specific binding of obestatin to various types of GPR39-expressing cells [3–5].
obestatin Neg (no) Binding (binding) of
9) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0
Moreover, multiple biological effects have been reported for desacyl-ghrelin, which essentially does not bind GHS-R1a.
ghrelin Neg (not) Binding (bind) of
10) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.87 Pain Relevance 0.16
The array of known and proposed interactions of ghrelin with key metabolic signals makes ghrelin and its receptor prime targets for drug development.


1.

ghrelin Binding (interactions) of
11) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Abstract Doc Link PMC2925380 Disease Relevance 0.28 Pain Relevance 0
Ghrelin stimulates the gastroduodenal motility in both fed and fasted states, des-acyl ghrelin inhibits the stomach motility in the fasted state, and obestatin inhibits the gastroduodenal motility in the fed state of animals (Table 1).
ghrelin Binding (inhibits) of in stomach
12) Confidence 0.21 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0
This staining pattern may arise if the polyclonal antibody is detecting the ligand/receptor complex and is consistent with the finding of Camina et al. [65] that the ghrelin/GHSR-1a complex progressively disappears from the plasma membrane after binding of the ligand and accumulates in the perinuclear region.
ghrelin Binding (binding) of in plasma
13) Confidence 0.21 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0.06
The array of known and proposed interactions of ghrelin with key metabolic signals makes ghrelin and its receptor prime targets for drug development.


1.

ghrelin Binding (makes) of
14) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Abstract Doc Link PMC2925380 Disease Relevance 0.28 Pain Relevance 0
A physiological distinction pertinent to CNS actions of ghrelin, but not obestatin, is that only ghrelin exhibits specific saturable binding to and endocytosis by cerebral microvessel endothelial cells, thereby allowing measurable permeation of the blood-brain barrier [284, 286].
ghrelin Binding (binding) of in blood
15) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.38 Pain Relevance 0.04
Ghrelin crosses the blood-brain barrier and directly inhibits leptin neurons and stimulates NPY/AGRP and orexin neurons [333], which are located, respectively, in the arcuate nucleu and lateral hypothalamus.
Ghrelin Binding (inhibits) of in lateral
16) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.27 Pain Relevance 0.34
A physiological distinction pertinent to CNS actions of ghrelin, but not obestatin, is that only ghrelin exhibits specific saturable binding to and endocytosis by cerebral microvessel endothelial cells, thereby allowing measurable permeation of the blood-brain barrier [284, 286].
obestatin Binding (binding) of in blood
17) Confidence 0.20 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.38 Pain Relevance 0.04
In addition, scientists at Merck laboratories demonstrated that Ser2 mono-octanoylated ghrelin 1–28 binds to GHS-R1a in vitro.
ghrelin Binding (binds) of
18) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.09 Pain Relevance 0.05
Histamine-2 agonists and gastrin synergize in promoting preprandial acid secretion [516, 517], thus illustrating intragastric interactions with ghrelin.
ghrelin Binding (interactions) of associated with agonist
19) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.61 Pain Relevance 0.42
A physiological distinction pertinent to CNS actions of ghrelin, but not obestatin, is that only ghrelin exhibits specific saturable binding to and endocytosis by cerebral microvessel endothelial cells, thereby allowing measurable permeation of the blood-brain barrier [284, 286].
ghrelin Binding (binding) of in blood
20) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.37 Pain Relevance 0.04

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