INT11823

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 53
Total Number 56
Disease Relevance 45.84
Pain Relevance 7.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
Anatomy Link Frequency
liver 5
blood 2
bile duct 1
plasma 1
upper 1
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 5 99.96 Very High Very High Very High
Pain 51 99.58 Very High Very High Very High
abdominal pain 23 99.52 Very High Very High Very High
Arthritis 8 99.44 Very High Very High Very High
rheumatoid arthritis 12 99.28 Very High Very High Very High
alcohol 101 99.24 Very High Very High Very High
spinal inflammation 7 99.00 Very High Very High Very High
colic 33 98.96 Very High Very High Very High
Bile 55 98.68 Very High Very High Very High
anesthesia 18 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cholangitis 54 99.98 Very High Very High Very High
Hepatomegaly 9 99.96 Very High Very High Very High
Depression 4 99.96 Very High Very High Very High
Gallstones 156 99.88 Very High Very High Very High
Osteoarthritis 10 99.84 Very High Very High Very High
Seronegative Spondarthritis 6 99.84 Very High Very High Very High
Granuloma 2 99.84 Very High Very High Very High
Alcohol Addiction 31 99.82 Very High Very High Very High
Lymphadenopathy 1 99.68 Very High Very High Very High
Diabetes Mellitus 128 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, this study indicates that increased levels of serum GGT may be significantly related to the presence of DPP in patients with type 2 DM.
Positive_regulation (increased) of GGT associated with neuropathy and diabetes complications
1) Confidence 0.67 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883349 Disease Relevance 1.06 Pain Relevance 0
The laboratory findings at the time of her second admission revealed a white blood count of 11.7 cells/nL, a slightly elevated CRP level of 0.83 mg/dL and normal liver test results apart from an elevated GGT level of 84 U/L.
Positive_regulation (elevated) of GGT in liver
2) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2997099 Disease Relevance 0.71 Pain Relevance 0.17
Of the 198 adverse events that were reported, 17 were rated as severe, including fatigue, gastrointestinal pain, irritability, nausea, somnolence (2 reports), headache (4 reports from 3 subjects), injection site pain, injection site mass, lethargy, depression, increased gamma-glutamyl transferase (GGT) level (an index of heavy drinking) (Conigrave et al 2002), back pain, and flatulence.
Positive_regulation (increased) of GGT associated with pain, flatulence, depression, vomiting, fatigue, headache and backache
3) Confidence 0.67 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376083 Disease Relevance 0.96 Pain Relevance 0.66
The administration of growth hormone opposes the beneficial effects of this pathway by downregulating GST and upregulating GGT activities (Brown-Borg et al. 2005).
Positive_regulation (upregulating) of GGT
4) Confidence 0.67 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.49 Pain Relevance 0
It was only after the elevated GGT was noted despite the normal ALP that we began to strongly suspect cholestasis and therefore PBC.
Positive_regulation (elevated) of GGT associated with biliary liver cirrhosis and gallstones
5) Confidence 0.67 Published 2008 Journal Cases J Section Body Doc Link PMC2475516 Disease Relevance 0.79 Pain Relevance 0.06
If simple telangiectasis can rarely provoke a painful liver with a slight elevation of GGT, arteriovenous shunts are more communicative.
Positive_regulation (elevation) of GGT in liver associated with pain and telangiectasia
6) Confidence 0.67 Published 2008 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2705726 Disease Relevance 1.27 Pain Relevance 0.13
Except for one instance of a grade 4 event (elevated gamma-glutamyltranspeptidase: GGT) in the 700 ?
Positive_regulation (elevated) of GGT
7) Confidence 0.67 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761172 Disease Relevance 1.57 Pain Relevance 0.22
GGT was significantly increased (p<0.05) from baseline to week 8 with 85% of all subjects demonstrating an increase during this period (8 females and 9 males).
Positive_regulation (increased) of GGT
8) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.12 Pain Relevance 0
Taken together it is possible to suggest that the increases in GGT may reflect changes associated with food intake and alcohol consumption of the participants.
Positive_regulation (increases) of GGT associated with alcohol
9) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0 Pain Relevance 0.08
However as food records were not maintained in this study we were unable to confirm that the increases in the GGT levels were related to these factors.
Positive_regulation (increases) of GGT
10) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.22 Pain Relevance 0.05
The results of the present study demonstrated that there was a significant increase in GGT (p<0.05) within group from baseline to week 8.
Positive_regulation (increase) of GGT
11) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.37 Pain Relevance 0.04
Alcohol and meat consumption are reported to increase GGT levels in a dose dependant manner.
Positive_regulation (increase) of GGT associated with alcohol
12) Confidence 0.67 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.30 Pain Relevance 0.05
Two patients developed grades three and four elevation of GGT in the follow-up period 8 days after the third infusion; in one of the cases, a relationship to the study drug could not be ruled out by the investigator.
Positive_regulation (elevation) of GGT
13) Confidence 0.67 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 0.85 Pain Relevance 0.06
Clinical chemistry supported this mixed toxicity prediction to some extent, as ALP, GGT, AST, and LDH were increased.
Positive_regulation (increased) of GGT associated with toxicity
14) Confidence 0.67 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1277117 Disease Relevance 0.66 Pain Relevance 0.07
Abdominal metastases were determined by abdominal pain/tension, hepatomegaly, elevated GGT levels, serum LDH levels >500 IU, a N2 or N3 case, KPS</=70, sensitivity of 95.9, specificity of 7.1, PPV of 13.3, NPV of 92.1 and SMR of 4.1%.
Spec (determined) Positive_regulation (elevated) of GGT associated with abdominal pain, hepatomegaly and metastasis
15) Confidence 0.67 Published 2007 Journal Lung Cancer Section Abstract Doc Link 17566597 Disease Relevance 1.45 Pain Relevance 0.10
However, transient increase in NAG, NAG-B, alpha-GST, beta-Gr, GGT and beta2M enzymes was observed.
Positive_regulation (increase) of GGT
16) Confidence 0.67 Published 2006 Journal Prz. Lek. Section Abstract Doc Link 17642144 Disease Relevance 0.17 Pain Relevance 0.34
A significant increased prevalence of abnormal gamma-glutamyl transpeptidase (GGT) and higher mean GGT were found in those with chloracne, compared to those without.
Positive_regulation (increased) of GGT associated with chloracne
17) Confidence 0.67 Published 1984 Journal Am. J. Ind. Med. Section Abstract Doc Link 6142642 Disease Relevance 0.90 Pain Relevance 0.07
Liver enzymes are usually elevated, especially GGT, ASAT and ALAT.
Positive_regulation (elevated) of GGT in Liver
18) Confidence 0.67 Published 2004 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 15696851 Disease Relevance 1.81 Pain Relevance 0.25
The hepatobiliary enzymes (ALP, GGT, and AST) were increased at stage A and significantly decreased at stage B.
Positive_regulation (increased) of GGT
19) Confidence 0.67 Published 1992 Journal Clin Investig Section Abstract Doc Link 1600331 Disease Relevance 0.62 Pain Relevance 0.21
-glutamyl transpeptidase (GGT) levels were elevated about 1.5-fold of normal limits and the aspartate aminotransferase (AST) level was marginally elevated.
Positive_regulation (elevated) of GGT
20) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1459933 Disease Relevance 0.83 Pain Relevance 0.06

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