INT118230

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 7.63
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
spinal 1
plasma 1
neurons 1
nerve 1
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 11 99.50 Very High Very High Very High
Dorsal horn 209 98.84 Very High Very High Very High
Dorsal horn neuron 26 98.48 Very High Very High Very High
c fibre 6 97.14 Very High Very High Very High
Adelta 4 96.98 Very High Very High Very High
Pain 15 95.64 Very High Very High Very High
Trk A 2 95.56 Very High Very High Very High
Sciatic nerve 17 95.52 Very High Very High Very High
Eae 14 94.36 High High
Glutamate 14 94.28 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 190 100.00 Very High Very High Very High
Apoptosis 113 100.00 Very High Very High Very High
Cancer 36 100.00 Very High Very High Very High
Necrosis 34 100.00 Very High Very High Very High
Death 75 99.96 Very High Very High Very High
Targeted Disruption 172 96.84 Very High Very High Very High
Pain 13 95.64 Very High Very High Very High
Metastasis 2 95.56 Very High Very High Very High
Post Operative Pain 2 93.72 High High
Disease 24 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding supports the association of TNFR1 with apoptosis [25] and also its association with the rapid luteal regression seen following parturition.
TNFR1 Binding (association) of associated with apoptosis
1) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.31 Pain Relevance 0
The TNF-alpha and TNFR1 immunofluorescence was assessed in the L4-L5 DRG affected by nerve injury for 1 and 2 weeks, and compared with the contralateral ones and those removed from naive or sham-operated rats.
TNFR1 Binding (compared) of in nerve associated with nervous system injury
2) Confidence 0.36 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16705482 Disease Relevance 0.40 Pain Relevance 0.17
is implicated in both cell proliferation and cell death; TNFR1 is generally associated with TNF?
TNFR1 Binding (associated) of associated with death
3) Confidence 0.33 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.40 Pain Relevance 0.03
The first receptor, p55/TNFR1, may bind either form of TNF?
TNFR1 Binding (bind) of
4) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.40 Pain Relevance 0.07
binds to p55/TNFR1 in the TNF?
TNFR1 Binding (binds) of
5) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.56 Pain Relevance 0.14
This finding supports the association of TNFR1 with apoptosis [25] and also its association with the rapid luteal regression seen following parturition.
TNFR1 Binding (association) of associated with apoptosis
6) Confidence 0.31 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.31 Pain Relevance 0
The effects of TNF-alpha on Adelta/C fiber-evoked monosynaptic and polysynaptic or spontaneous EPSCs were significantly blocked by 5 microM TNF-alpha antagonist that inhibits TNF-alpha binding to its type 1 receptor (TNFR1).
TNFR1 Binding (binding) of associated with c fibre, antagonist and adelta
7) Confidence 0.27 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18543334 Disease Relevance 0.49 Pain Relevance 1.03
receptor TNFR1 is upregulated in both adult DRG and dorsal horn neurons after VRT [12], which may explain the observation that the spinal application of TNF?
TNFR1 Binding (receptor) of in spinal associated with dorsal horn neuron
8) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 1.23 Pain Relevance 1.09
Previous work has demonstrated that interfering with TNFR1 signaling in hippocampal neurons disrupts AMPAR trafficking to the membrane and decreases both mEPSC frequency and amplitude without altering glutamate release probability [25].
TNFR1 Binding (interfering) of in neurons associated with glutamate
9) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.08 Pain Relevance 0.23
variant and a complex of TNFR1 and TNF?
TNFR1 Binding (complex) of
10) Confidence 0.26 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816690 Disease Relevance 0.61 Pain Relevance 0.64
might bind to the cell-associated TNFR1 or TNFR2 instead of back onto the receptor fusion [20].
TNFR1 Spec (might) Binding (bind) of
11) Confidence 0.26 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816690 Disease Relevance 0.22 Pain Relevance 0.23
Once complexed, p55/TNFR1-TRADD may either facilitate apoptosis by activation of caspase-8 or enhance cell survival through disinhibition of the nuclear transcription factor, NF?
TNFR1 Binding (complexed) of associated with apoptosis
12) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.47 Pain Relevance 0.06
Once released, soluble TNF circulates as a homotrimer that will bind with one of two distinct receptors of 55-kDa (TNFR1) or 75-kDa (TNFR2) molecular weight.
TNFR1 Binding (bind) of
13) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.51 Pain Relevance 0.13
The column selectively bound soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) and soluble interleukin-2 receptors (sIL2-R) by lowering plasma levels in patients with metastatic cancer.
tumor necrosis factor receptors 1 and 2 Binding (bound) of in plasma associated with necrosis, cancer and metastasis
14) Confidence 0.12 Published 2008 Journal Ther Apher Dial Section Abstract Doc Link 19140848 Disease Relevance 0.53 Pain Relevance 0
We also pretreated rats with a tumor necrosis factor receptor (TNFr) protein, p75 IgG fusion protein (5 to 10 mg/kg), to study the role of endogenous TNF in the development of pain behaviors after incision.
TNFr Binding (rats) of associated with pain, necrosis and cancer
15) Confidence 0.12 Published 2004 Journal J Pain Section Abstract Doc Link 15106128 Disease Relevance 0.61 Pain Relevance 0.57
For TNF receptor 1 (TNFR1), it has been shown that binding of TNF-?
TNFR1 Binding (binding) of
16) Confidence 0.11 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.48 Pain Relevance 0

General Comments

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