INT11824

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 10 99.34 Very High Very High Very High
anesthesia 1 89.24 High High
Bile 3 80.76 Quite High
addiction 5 78.88 Quite High
antagonist 1 31.28 Quite Low
Opioid 1 30.84 Quite Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Exfoliation Syndrome 69 96.64 Very High Very High Very High
Intrahepatic Cholestasis 3 88.40 High High
Cirrhosis 1 86.72 High High
Gallstones 1 81.76 Quite High
Bile Duct Neoplasms 1 81.24 Quite High
Pathologic Constriction 1 79.00 Quite High
Alcohol Addiction 6 75.00 Quite High
Extrahepatic Cholestasis 1 73.12 Quite High
Glaucoma 52 67.56 Quite High
Genetic Predisposition To Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of 70 patients (35 placebo; 35 naltrexone) who met an a priori definition of compliance (80% tablet consumption, attendance at all follow-up appointments), those allocated to naltrexone reported consuming half the amount of alcohol (P: < 0.05), had greater median reduction in serum GGT activity (P: < 0.05), and greater reduction in alcohol craving (OCDS total score: P: < 0.05; Obsessive subscale score: P: < 0.05), compared to patients in the placebo group.
Negative_regulation (reduction) of GGT associated with alcohol
1) Confidence 0.57 Published 2000 Journal Alcohol Alcohol. Section Abstract Doc Link 11093966 Disease Relevance 0.07 Pain Relevance 0.32
The hepatobiliary enzymes (ALP, GGT, and AST) were increased at stage A and significantly decreased at stage B.
Negative_regulation (decreased) of GGT
2) Confidence 0.41 Published 1992 Journal Clin Investig Section Abstract Doc Link 1600331 Disease Relevance 0.62 Pain Relevance 0.21
When the combined effects of these three SNPs were tabulated, the GGT haplotype was significantly overrepresented while the two haplotypes of GAC and TGC were significantly underrepresented in the XFS patients (Table 5).
Negative_regulation (overrepresented) of GGT associated with exfoliation syndrome
3) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.69 Pain Relevance 0

General Comments

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