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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.33
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
endothelial cell 1
colon 1
hearts 1
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 92.92 High High
cytokine 10 88.96 High High
Inflammatory response 5 85.24 High High
anesthesia 2 10.00 Low Low
aspirin 7 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 9 100.00 Very High Very High Very High
Colon Cancer 12 99.08 Very High Very High Very High
Carcinoma 2 98.88 Very High Very High Very High
Apoptosis 10 96.72 Very High Very High Very High
Pressure And Volume Under Development 5 95.44 Very High Very High Very High
Sepsis 7 95.32 Very High Very High Very High
Necrosis 17 93.84 High High
INFLAMMATION 28 92.92 High High
Pancreatitis 26 90.72 High High
Malignant Neoplastic Disease 5 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of SND1 in colon cancer cells caused down-regulation of APC and activation of the Wnt signaling pathway as a consequence, without altering APC mRNA levels.
Transcription (levels) of APC in colon associated with familial adenomatous polyposis and colon cancer
1) Confidence 0.45 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.00 Pain Relevance 0
Binding of APC to the endothelial cell protein C receptor results in a number of actions, including increased activity of APC itself and inhibition of both NF-?
Transcription (activity) of APC in endothelial cell
2) Confidence 0.27 Published 2005 Journal Crit Care Section Body Doc Link PMC1175873 Disease Relevance 1.79 Pain Relevance 0.33
Specifically, the mutation of APC is a leading cause of colorectal carcinomas [16], and the relative mRNA and protein expression of ?
Transcription (mutation) of APC associated with colon cancer
3) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.53 Pain Relevance 0
METHODS: Affymetrix rat U34A gene chips were used to explore the transcriptional response to IPC and APC, sustained ischemia (110 min) without reperfusion, and time-matched perfusion in isolated rat hearts.
Transcription (transcriptional) of APC in hearts
4) Confidence 0.13 Published 2004 Journal Anesthesiology Section Body Doc Link 15108959 Disease Relevance 0 Pain Relevance 0

General Comments

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