INT118258

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 4.26
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ENPP1) extracellular space (ENPP1) small molecule metabolic process (ENPP1)
plasma membrane (ENPP1)
Anatomy Link Frequency
articular cartilage 2
ENPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 206 100.00 Very High Very High Very High
Inflammation 6 87.96 High High
reflex sympathetic dystrophy 2 75.00 Quite High
Neuropeptide 2 25.00 Low Low
adenocard 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 210 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 20 100.00 Very High Very High Very High
Calcification 168 89.52 High High
Neurogenic Inflammation 4 87.96 High High
Osteogenic Sarcomas 10 59.44 Quite High
Chondrocalcinosis 12 53.80 Quite High
Disease 20 17.36 Low Low
Frailty 6 5.00 Very Low Very Low Very Low
Amputation 6 5.00 Very Low Very Low Very Low
Ankylosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding was consistent with the previous finding that ENPP1 was upregulated in the calcified regions of OA menisci [46] and that ANKH was upregulated in OA articular cartilage [47].
Positive_regulation (upregulated) of ENPP1 in articular cartilage associated with osteoarthritis
1) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.20 Pain Relevance 0.41
This finding was consistent with the previous finding that ENPP1 was upregulated in the calcified regions of OA menisci [46] and that ANKH was upregulated in OA articular cartilage [47].
Positive_regulation (upregulated) of ENPP1 in articular cartilage associated with osteoarthritis
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.30 Pain Relevance 0.44
In conclusion, the results presented herein render this particular ACE gene polymorphism unlikely to be a predisposing factor for CRPS I.
Positive_regulation (factor) of CRPS I associated with complex regional pain syndromes
3) Confidence 0.03 Published 2004 Journal Eur J Pain Section Abstract Doc Link 15109972 Disease Relevance 0.89 Pain Relevance 0.15
However, in the present study the D allele frequency was not increased in CRPS I cases (0.51 for D allele, 0.49 for I allele).
Neg (not) Positive_regulation (increased) of CRPS I associated with complex regional pain syndromes
4) Confidence 0.03 Published 2004 Journal Eur J Pain Section Abstract Doc Link 15109972 Disease Relevance 0.87 Pain Relevance 0.16

General Comments

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