INT11826

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 62
Total Number 62
Disease Relevance 45.09
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Link Frequency
blood 8
plasma 5
heart 2
macrophages 1
liver 1
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 151 99.44 Very High Very High Very High
Angina 45 99.28 Very High Very High Very High
ischemia 42 98.84 Very High Very High Very High
Inflammation 221 97.66 Very High Very High Very High
addiction 4 97.44 Very High Very High Very High
Kinase C 60 94.92 High High
tolerance 33 94.92 High High
Eae 1 94.68 High High
aspirin 22 93.84 High High
Pain 29 93.64 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 737 100.00 Very High Very High Very High
Obesity 194 100.00 Very High Very High Very High
Hyperlipidemia 105 99.96 Very High Very High Very High
Cv Unclassified Under Development 58 99.96 Very High Very High Very High
Hyperlipoproteinemia Type Ii 85 99.88 Very High Very High Very High
Rheumatoid Arthritis 186 99.82 Very High Very High Very High
Nicotine Addiction 25 99.68 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

115 99.58 Very High Very High Very High
Aging 115 99.50 Very High Very High Very High
Diabetes Mellitus 554 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, flufenamic acid and indomethacin were both found to increase the synthesis of mRNA of the LDL receptor with a subsequent increase of LDL receptor protein.
Positive_regulation (increase) of LDL receptor
1) Confidence 0.62 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10395027 Disease Relevance 0.26 Pain Relevance 0.60
Triglycerides, LDL-cholesterol and total cholesterol were elevated in patients with UAP as opposed to patients with SAP and the control subjects, while HDL levels were elevated in the control subjects when compared to patients with SAP and UAP.
Positive_regulation (elevated) of LDL-cholesterol associated with angina and disorder of lipid metabolism
2) Confidence 0.55 Published 2005 Journal Free Radic. Res. Section Abstract Doc Link 16028367 Disease Relevance 1.63 Pain Relevance 1.29
Second, the epidemiological relationship between elevated total cholesterol and atherosclerosis can be attributed to a large extent to elevated LDL-cholesterol.
Positive_regulation (elevated) of LDL-cholesterol associated with increased venous pressure under development and disorder of lipid metabolism
3) Confidence 0.48 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 1.04 Pain Relevance 0
Thus, this combination should be considered in patients who despite statin therapy have elevated LDL-cholesterol in combination with elevated triglycerides and/or low HDL-cholesterol.
Positive_regulation (elevated) of LDL-cholesterol associated with hypertriglyceridemia and disorder of lipid metabolism
4) Confidence 0.48 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.65 Pain Relevance 0
There may have been a small increase in absolute LDL-cholesterol levels as a result of the drift in HDL-cholesterol (because the calculated difference method has been used for LDL-cholesterol), but the sustained difference between the two groups represents a reduction of approximately 9% in LDL-cholesterol at 3 years attributable to active treatment.
Positive_regulation (increase) of LDL-cholesterol associated with disorder of lipid metabolism
5) Confidence 0.48 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.34 Pain Relevance 0.09
In patients with hyperlipidemia, omega 3 fatty acids decrease low-density-lipoprotein (LDL) cholesterol if the saturated fatty acid content is decreased, otherwise there is a slight increase, but at high doses (32 g) they lower LDL cholesterol; furthermore, they consistently lower serum triglycerides in normal subjects and in patients with hypertriglyceridemia whereas the effect on high-density lipoprotein (HDL) varies from no effect to slight increases.
Positive_regulation (increase) of LDL cholesterol associated with hyperlipidemia and disorder of lipid metabolism
6) Confidence 0.44 Published 1991 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 1908631 Disease Relevance 0.77 Pain Relevance 0.09
We may consequently suggest that the low levels of enzyme activity in the plasma of ERA patients at baseline could be the combined effect of the inflammation-induced reduction of enzyme secretion from macrophages and the expected increase in plasma enzyme levels due to the elevation of LDL-cholesterol in plasma of ERA patients.
Positive_regulation (elevation) of LDL-cholesterol in macrophages associated with inflammation and rheumatoid arthritis
7) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 0.79 Pain Relevance 0.33
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Positive_regulation (increase) of LDL-cholesterol associated with rheumatoid arthritis and disorder of lipid metabolism
8) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.43 Pain Relevance 0.30
The LDL-cholesterol dependent activation of Receptor Ck was found to down-regulate hTERT gene transcription by down-regulating the transcription of c-myc gene through PKC inhibition (Figure 11).
Positive_regulation (activation) of LDL-cholesterol associated with kinase c
9) Confidence 0.36 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0.19
Finally, many studies have shown that lowering LDL-cholesterol by statins or other forms of therapy can reduce morbidity and mortality from atherosclerosis.3,4
Positive_regulation (lowering) of LDL-cholesterol associated with increased venous pressure under development
10) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 1.09 Pain Relevance 0
In patients with normal triglyceride and HDL-cholesterol levels but elevated LDL-cholesterol levels despite statin therapy several approaches are possible.
Positive_regulation (elevated) of LDL-cholesterol associated with disorder of lipid metabolism
11) Confidence 0.32 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.41 Pain Relevance 0.04
Low-density lipoprotein levels were usually reduced in those patients with elevated levels and high-density lipoprotein levels increased when baseline levels were low.
Positive_regulation (increased) of Low-density lipoprotein
12) Confidence 0.31 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3318450 Disease Relevance 0.70 Pain Relevance 0.07
This is supported by the observation that risk factors such as aging, smoking, hypertension, elevated low-density lipoprotein (LDL) levels, diabetes, and ischemia have been shown to alter endothelial function (Luscher et al 1993).
Positive_regulation (elevated) of low-density lipoprotein associated with nicotine addiction, aging, diabetes mellitus, ischemia and cv unclassified under development
13) Confidence 0.29 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.39 Pain Relevance 0.13
Other studies have shown a down-regulation of SREBP-2, a gene encoding the sterol regulatory element-binding protein-2 that mediates cholesterol synthesis, as well as the two SREBP-2 target genes, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) and low density lipoprotein receptor (LDLR), in HepG2 cells exposed to 30??
Positive_regulation (encoding) of low density lipoprotein receptor
14) Confidence 0.28 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.56 Pain Relevance 0.03
Other studies have shown a down-regulation of SREBP-2, a gene encoding the sterol regulatory element-binding protein-2 that mediates cholesterol synthesis, as well as the two SREBP-2 target genes, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) and low density lipoprotein receptor (LDLR), in HepG2 cells exposed to 30??
Positive_regulation (encoding) of LDLR
15) Confidence 0.28 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.56 Pain Relevance 0.03
In ST delta(+) patients, myocardial thromboxane synthesis changed before lactate production and correlated with the increase of lipid peroxides on low-density lipoprotein of the coronary venous blood.
Positive_regulation (increase) of low-density lipoprotein in blood
16) Confidence 0.24 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.20 Pain Relevance 0.03
They had (i) negative fractional lactate extraction; (ii) pacing-induced decreases of plasma thromboxane A2 levels in the coronary sinus blood (564 +/- 57 versus 479 +/- 47 ng/l, P < 0.05) at 2 min of peak-pacing; the data increased at 10 min of peak-pacing (564 +/- 57 versus 620 +/- 60 ng/l, P < 0.05), then returned to baseline levels at 5 and 10 min post-pacing; (iii) significantly increased lipid peroxides on low-density lipoprotein of the coronary sinus blood at 2 and 10 min of peak-pacing (each P < 0.001), as well as at 5 min post-pacing (P < 0.05); (iv) significant correlation between thromboxane A2 levels and lipid peroxides on low-density lipoprotein of the coronary sinus blood samples. 3.
Positive_regulation (increased) of low-density lipoprotein in coronary sinus
17) Confidence 0.24 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9505863 Disease Relevance 0.34 Pain Relevance 0.10
Genetic variations in LDL receptor expression were shown to be associated with diminished statin response (i.e., diminished effects of statins on in vivo lipid reductions and on in vitro LDL receptor induction); and similarly, attenuated statin-mediated changes were observed in subjects with genetic mutations in HMG CoA reductase[20].
Positive_regulation (induction) of LDL receptor
18) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2992529 Disease Relevance 0 Pain Relevance 0
These beneficial effects were associated with reduction in the levels of triglycerides (by 29%) and LDL-C (by 5%), and an increase in HDL-C (by 7%) and LDL particle size (Vakkilainen et al 2003).
Positive_regulation (increase) of LDL particle associated with disorder of lipid metabolism
19) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.28 Pain Relevance 0
In subjects with familial hyperlipidemia, elevated blood oxLDL and LDL-cholesterol levels were associated with increased carotid intimal-media thickness.23 In two other studies, elevated plasma oxLDL levels were associated with increased carotid intimal-media thickness in asymptomatic subjects whose relatives had familial hypercholesterolemia and also in asymptomatic middle-aged males.24,25
Positive_regulation (elevated) of LDL-cholesterol in plasma associated with hyperlipoproteinemia type ii and hyperlipidemia
20) Confidence 0.22 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862667 Disease Relevance 0.67 Pain Relevance 0

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