INT118270

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.02
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
liver 1
vasculature 1
brain 1
platelets 1
bladder 1
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 57 99.98 Very High Very High Very High
Bile 10 99.28 Very High Very High Very High
Stimulus evoked pain 6 98.48 Very High Very High Very High
Inflammation 56 97.68 Very High Very High Very High
adenocard 55 97.38 Very High Very High Very High
noradrenaline 12 96.80 Very High Very High Very High
Neuropathic pain 2 94.72 High High
Pain 22 91.84 High High
antagonist 95 89.72 High High
cerebral cortex 1 88.24 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 7 98.48 Very High Very High Very High
Fibrosis 2 98.36 Very High Very High Very High
Injury 314 98.24 Very High Very High Very High
Cancer 5 98.24 Very High Very High Very High
Pain 26 97.80 Very High Very High Very High
INFLAMMATION 54 97.68 Very High Very High Very High
Pancreatitis 6 96.96 Very High Very High Very High
Diabetes Mellitus 12 94.92 High High
Neuropathic Pain 4 94.72 High High
Benign Prostatic Hypertrophy 1 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After verifying the effect of P2Y2-R siRNA #2 transfection on SIRC cells, we wanted to correlate this effect with siRNA in vivo migration assays.
Regulation (effect) of P2Y2-R in SIRC
1) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.32 Pain Relevance 0
Cells were transfected with 300 nM P2Y2-R siRNA #1, 300 nM P2Y2-R siRNA #2, or the transfection reagent alone (control) for 72 h and then processed for ICC.
Regulation (control) of P2Y2-R
2) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.17 Pain Relevance 0.04
The effect of the siRNA against P2Y2-R was tested in living animals.
Regulation (effect) of P2Y2-R
3) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.07 Pain Relevance 0
All these results confirm the P2Y2-R silencing efficiency of P2Y2-R siRNA #2 and also the involvement of P2Y2-R in the Ap4A re-epithelialization process.
Regulation (efficiency) of P2Y2-R
4) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.31 Pain Relevance 0
All these results confirm the P2Y2-R silencing efficiency of P2Y2-R siRNA #2 and also the involvement of P2Y2-R in the Ap4A re-epithelialization process.
Regulation (efficiency) of P2Y2-R
5) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.31 Pain Relevance 0
There is also emerging evidence for roles for P2Y, and P2Y2 receptors, subtypes of G protein-coupled P2 receptors, in pain hypersensitivity.
Regulation (roles) of P2Y associated with hypersensitivity and stimulus evoked pain
6) Confidence 0.45 Published 2005 Journal Curr Opin Investig Drugs Section Abstract Doc Link 15675605 Disease Relevance 1.36 Pain Relevance 1.02
There is also emerging evidence for roles for P2Y, and P2Y2 receptors, subtypes of G protein-coupled P2 receptors, in pain hypersensitivity.
Regulation (roles) of P2Y2 associated with hypersensitivity and stimulus evoked pain
7) Confidence 0.45 Published 2005 Journal Curr Opin Investig Drugs Section Abstract Doc Link 15675605 Disease Relevance 1.36 Pain Relevance 1.02
To test the efficacy of synthesized siRNAs targeting P2Y2-R, immunocytochemistry, immunohistochemistry, and quantitative RT-PCR (qRT–PCR) assays were performed.
Regulation (targeting) of P2Y2-R
8) Confidence 0.27 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2695252 Disease Relevance 0.25 Pain Relevance 0.07
To test the efficacy of synthesized siRNAs targeting P2Y2-R, immunocytochemistry (ICC), immunohistochemistry (IHC), and qRT–PCR assays were performed.
Regulation (targeting) of P2Y2-R
9) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.18 Pain Relevance 0.05
A1R and P2Y2R immunoreactivities were present in all three rat brain regions examined (Figure 3A, B, F).
Spec (examined) Regulation (immunoreactivities) of P2Y2R in brain
10) Confidence 0.25 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.21
In the renal vasculature both P2X1 and P2Y2 receptors are important for neurogenic contraction.
Regulation (important) of P2Y2 in vasculature
11) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.40 Pain Relevance 0.18
Our data suggest distinct roles for CD39 and P2-purinergic signaling in both tissue remodeling and fibrogenesis with respect to human pancreatic diseases.
Regulation (roles) of P2-purinergic associated with fibrosis and pancreatitis
12) Confidence 0.20 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.27 Pain Relevance 0.28
Adenosine containing dinucleotides exhibit some level of activity on P2Y1 while uridine containing dinucleotides have some level of agonist response on P2Y2 and P2Y6.
Regulation (response) of P2Y2 associated with adenocard and agonist
13) Confidence 0.14 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096529 Disease Relevance 0 Pain Relevance 0.17
The active moiety is a reactive thiol derivative that targets P2Y (12) on platelets.
Regulation (targets) of P2Y in platelets
14) Confidence 0.04 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852221 Disease Relevance 0 Pain Relevance 0.27
Muscarinic (M(2), M(3)), purinergic (P2X, P2Y) and adrenergic receptors (alpha(1), beta(3)) are targets of efferent sympathetic and parasympathetic bladder innervation.
Regulation (targets) of P2Y in bladder
15) Confidence 0.01 Published 2004 Journal Urologe A Section Abstract Doc Link 15112040 Disease Relevance 1.02 Pain Relevance 0
Portal fibroblasts regulate P2Y receptormediated bile duct epithelial proliferation via expression of NTPDase2 [117] (see liver section, below).
Regulation (regulate) of P2Y in liver associated with bile
16) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0 Pain Relevance 0.12

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