INT118274

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.81
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
monocyte 2
melanocytes 2
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 7 100.00 Very High Very High Very High
qutenza 11 99.98 Very High Very High Very High
Morphine 20 99.38 Very High Very High Very High
cINOD 8 95.60 Very High Very High Very High
opioid receptor 1 90.32 High High
diclofenac 6 87.60 High High
Opioid 4 85.76 High High
Antinociceptive 1 83.76 Quite High
Inflammation 4 82.96 Quite High
analgesia 1 82.32 Quite High
Disease Link Frequency Relevance Heat
Adhesions 6 99.98 Very High Very High Very High
Apoptosis 51 99.74 Very High Very High Very High
Cancer 42 96.08 Very High Very High Very High
Bordatella Infection 1 89.52 High High
Death 3 88.76 High High
INFLAMMATION 6 82.96 Quite High
Pain 1 81.92 Quite High
Rheumatoid Arthritis 3 81.00 Quite High
Skin Cancer 22 78.96 Quite High
Keratosis 1 78.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, morphine-induced apoptosis seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K), as PI3K inhibition by the PI3K inhibitor LY294002 significantly enhanced morphine-induced apoptosis.
Positive_regulation (dependent) of Positive_regulation (activation) of PI3K associated with apoptosis and morphine
1) Confidence 0.64 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.10 Pain Relevance 0.93
We found that DPDPE-triggered monocyte adhesion requires PI3Kgamma activation and involves Src kinases, the guanine nucleotide exchange factor Vav-1, and the small GTPase Rac1.
Positive_regulation (requires) of Positive_regulation (activation) of PI3Kgamma in monocyte associated with adhesions
2) Confidence 0.49 Published 2006 Journal J. Immunol. Section Abstract Doc Link 16424197 Disease Relevance 0.62 Pain Relevance 0.49
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.
Positive_regulation (induces) of Positive_regulation (activation) of PI3K associated with qutenza
3) Confidence 0.49 Published 2007 Journal Antioxid. Redox Signal. Section Title Doc Link 17979524 Disease Relevance 0 Pain Relevance 0.91
BV increased the number of melanocytes dose and time dependently through PKA, ERK, and PI3K/Akt activation.
Positive_regulation (increased) of Positive_regulation (activation) of PI3K in melanocytes
4) Confidence 0.49 Published 2007 Journal Exp. Mol. Med. Section Abstract Doc Link 18059136 Disease Relevance 0.25 Pain Relevance 0.21
In addition, morphine-induced apoptosis seems to be dependent on the activation of phosphatidylinositol 3-kinase (PI3K), as PI3K inhibition by the PI3K inhibitor LY294002 significantly enhanced morphine-induced apoptosis.
Positive_regulation (dependent) of Positive_regulation (activation) of phosphatidylinositol 3-kinase associated with apoptosis and morphine
5) Confidence 0.46 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.10 Pain Relevance 0.93
Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C 4.


Positive_regulation (induces) of Positive_regulation (activation) of PI3K associated with kinase c
6) Confidence 0.19 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.65 Pain Relevance 0.05
Cyclo-oxygenase-2-mediated synthesis of prostaglandin E(2) (PGE(2)) leads to activation of mitogen-activated protein kinase (MAPK), as well as phosphatidylinositol 3-kinase (PI3K)/Akt pathways.
Positive_regulation (leads) of Positive_regulation (activation) of phosphatidylinositol 3-kinase
7) Confidence 0.02 Published 2007 Journal Br. J. Dermatol. Section Abstract Doc Link 17488403 Disease Relevance 1.10 Pain Relevance 0.77
In nonrenal tissue, chronic exposure to ET-1 stimulates eNOS expression via the ET(B) receptor and activation of phosphatidylinositol 3-kinase (PI3K).
Positive_regulation (stimulates) of Positive_regulation (activation) of phosphatidylinositol 3-kinase
8) Confidence 0.02 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15113749 Disease Relevance 0 Pain Relevance 0.06
This effect appears to be related to activation of phospholipase C, phosphatidylinositol-3 kinase, p38 kinase, and PKC.
Spec (appears) Positive_regulation (related) of Positive_regulation (activation) of phosphatidylinositol-3 kinase associated with kinase c
9) Confidence 0.01 Published 2005 Journal Endocrinology Section Abstract Doc Link 15550506 Disease Relevance 0 Pain Relevance 0.27

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