INT118288

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.85
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EGF, EGFR) signal transduction (EGF, EGFR) extracellular region (EGF, EGFR)
plasma membrane (EGF, EGFR) endosome (EGFR) cell morphogenesis (EGFR)
Anatomy Link Frequency
colon 2
EGF (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 85.60 High High
cINOD 118 78.28 Quite High
antagonist 4 65.28 Quite High
aspirin 8 59.96 Quite High
tolerance 1 55.20 Quite High
lidocaine 5 50.00 Quite Low
imagery 4 45.60 Quite Low
Immobilon 8 5.72 Low Low
Chronic pancreatitis 22 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 101 99.20 Very High Very High Very High
Pancreatic Cancer 181 97.36 Very High Very High Very High
Death 36 91.68 High High
Apoptosis 147 91.24 High High
Cancer 76 88.72 High High
Disease 16 87.24 High High
Lung Cancer 47 86.56 High High
Familial Adenomatous Polyposis 20 75.96 Quite High
Toxicity 1 62.64 Quite High
INFLAMMATION 19 58.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the HCEC study, EGF alone stimulated cell proliferation and increased autophosphorylation of EGFR in HCECs.
EGF Positive_regulation (increased) of Phosphorylation (autophosphorylation) of EGFR
1) Confidence 0.54 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
M sulindac sulfide blocked the ability of EGF to induce phosphorylation of EGFR in a dose dependent fashion.
EGF Positive_regulation (induce) of Phosphorylation (phosphorylation) of EGFR
2) Confidence 0.34 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.39 Pain Relevance 0
Gefitinib completely abolished EGF-induced phosphorylation of EGFR/MAP kinase and inhibited EGF-induced cell growth and invasion in pancreatic cancer cell lines (Li et al 2004).
EGF Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGFR associated with pancreatic cancer
3) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.98 Pain Relevance 0.03
Pretreatment with sulindac metabolites for 24 h blocked EGF-induced phosphorylation of both EGFR and ERK1/2 and decreased total EGFR protein expression.
EGF Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGFR
4) Confidence 0.23 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.70 Pain Relevance 0.23
EGF treatment rapidly induced phosphorylation of both EGFR and ERK1/2 in HT29 colon cancer cells.
EGF Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGFR in colon associated with colon cancer
5) Confidence 0.23 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.69 Pain Relevance 0.25
We report, for the first time, that sulindac metabolites block both basal and EGF induced phosphorylation of EGFR and downregulate total EGFR protein expression.
EGF Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGFR
6) Confidence 0.23 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.30 Pain Relevance 0.35
In Ist-Mes-1, Ist-Mes-2 and MPP89 cell lines, the addition of EGF at a concentration of 100 ng/mL significantly increased EGFR phosphorylation after 15 mins, when compared with the control.
EGF Positive_regulation (increased) of Phosphorylation (phosphorylation) of EGFR
7) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.15 Pain Relevance 0.04
EGFR phosphorylation was not changed in response to EGF or HB-EGF in Hsulf-1 expressing clones compared to controls (Figure 7 A).
EGF Neg (not) Positive_regulation (changed) of Phosphorylation (phosphorylation) of EGFR
8) Confidence 0.06 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.32 Pain Relevance 0
EGFR phosphorylation was not changed in response to EGF or HB-EGF in Hsulf-1 expressing clones compared to controls (Figure 7 A).
EGF Neg (not) Positive_regulation (changed) of Phosphorylation (phosphorylation) of EGFR
9) Confidence 0.06 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox