INT11829

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 54
Total Number 54
Disease Relevance 7.03
Pain Relevance 23.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
brain 15
liver 11
plasma 2
colon 2
central nervous system 1
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 102 99.98 Very High Very High Very High
narcan 35 99.84 Very High Very High Very High
cocaine 32 99.84 Very High Very High Very High
Clonidine 12 99.32 Very High Very High Very High
Endogenous opioid 20 99.24 Very High Very High Very High
Intracerebroventricular 16 99.14 Very High Very High Very High
methadone 5 98.72 Very High Very High Very High
cerebral cortex 4 98.72 Very High Very High Very High
ischemia 24 98.70 Very High Very High Very High
Analgesic 7 98.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 24 100.00 Very High Very High Very High
Necrosis 6 98.88 Very High Very High Very High
Cv Unclassified Under Development 15 98.70 Very High Very High Very High
Liver Failure 6 98.62 Very High Very High Very High
Body Weight 3 98.24 Very High Very High Very High
INFLAMMATION 4 98.22 Very High Very High Very High
Cv General 4 Under Development 9 98.04 Very High Very High Very High
Pain 3 97.58 Very High Very High Very High
Injury 8 97.56 Very High Very High Very High
Ulcers 3 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity.
Negative_regulation (inhibited) of ODC in brain
1) Confidence 0.59 Published 1989 Journal Life Sci. Section Abstract Doc Link 2494400 Disease Relevance 0.10 Pain Relevance 0.75
Significant decreases in ODC activity were seen at doses of BE as low as 0.5 micrograms/g brain wt.
Negative_regulation (decreases) of ODC in brain
2) Confidence 0.59 Published 1991 Journal Pediatr. Res. Section Abstract Doc Link 2014156 Disease Relevance 0 Pain Relevance 0.23
Central (but not peripheral) administration of BE reduced lung ODC activity by as much as 80% in the 6-d-old rat.
Negative_regulation (reduced) of ODC in lung
3) Confidence 0.59 Published 1991 Journal Pediatr. Res. Section Abstract Doc Link 2014156 Disease Relevance 0 Pain Relevance 0.23
In contrast to the reductions in ODC activity, plasma levels of corticosterone in animals administered BE were approximately five times higher than those seen in control animals.
Negative_regulation (reductions) of ODC in plasma
4) Confidence 0.59 Published 1991 Journal Pediatr. Res. Section Abstract Doc Link 2014156 Disease Relevance 0 Pain Relevance 0.23
Ischemia contributes to adverse effects of cocaine on brain development: suppression of ornithine decarboxylase activity in neonatal rat.
Negative_regulation (suppression) of ornithine decarboxylase in brain associated with ischemia and cocaine
5) Confidence 0.58 Published 1991 Journal Brain Res. Bull. Section Title Doc Link 1786562 Disease Relevance 0.16 Pain Relevance 0.71
Cocaine caused inhibition of ornithine decarboxylase activity that was not secondary to local anesthesia, as lidocaine was ineffective.
Negative_regulation (inhibition) of ornithine decarboxylase associated with anesthesia, lidocaine and cocaine
6) Confidence 0.58 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1786562 Disease Relevance 0.15 Pain Relevance 0.79
Pretreatment with alpha-difluoromethylornithine (DFMO) significantly blocked the ODC activity at 2, 4, and 6 h.
Negative_regulation (blocked) of ODC
7) Confidence 0.58 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595561 Disease Relevance 0.78 Pain Relevance 0.29
These results demonstrate that ODC activity and edema formation are delayed in gerbils after the induction of transient ischemia even with the removal of anesthetic agents and their potentially protective effects.
Negative_regulation (delayed) of ODC associated with pressure and volume under development and ischemia
8) Confidence 0.58 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595561 Disease Relevance 0.87 Pain Relevance 0.29
DFMO treatment reduced both the ODC activity and edema formation, indicating a role for polyamines in postischemic edema formation.
Negative_regulation (reduced) of ODC associated with pressure and volume under development
9) Confidence 0.58 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595561 Disease Relevance 1.02 Pain Relevance 0.27
At PND 1 brain ornithine decarboxylase (ODC) activity was reduced in LOF- but not CLON-exposed pups of both sexes.
Neg (not) Negative_regulation (reduced) of ODC in brain associated with clonidine
10) Confidence 0.58 Published 1988 Journal Neurotoxicology Section Abstract Doc Link 2904669 Disease Relevance 0.17 Pain Relevance 0.71
At PND 1 brain ornithine decarboxylase (ODC) activity was reduced in LOF- but not CLON-exposed pups of both sexes.
Neg (not) Negative_regulation (reduced) of PND 1 brain ornithine decarboxylase in brain associated with clonidine
11) Confidence 0.58 Published 1988 Journal Neurotoxicology Section Abstract Doc Link 2904669 Disease Relevance 0.17 Pain Relevance 0.72
Thus, ODC inhibition in peripheral organs in rat pups given beta-endorphin intracisternally appears to reflect central effects of this neuropeptide.
Negative_regulation (inhibition) of ODC associated with neuropeptide
12) Confidence 0.58 Published 1986 Journal Life Sci. Section Abstract Doc Link 2941633 Disease Relevance 0 Pain Relevance 0.30
Intracisternal administration of beta-endorphin (1 microgram) to 6 day-old rats markedly decreased brain, liver, heart and kidney ODC activity.
Negative_regulation (decreased) of ODC in kidney
13) Confidence 0.58 Published 1986 Journal Life Sci. Section Abstract Doc Link 2941633 Disease Relevance 0 Pain Relevance 0.21
None of the toxins depressed ODC activity after the hepatectomy, in contrast to their depressant effects after acetaminophen.
Negative_regulation (depressed) of ODC associated with paracetamol
14) Confidence 0.57 Published 1985 Journal J. Lab. Clin. Med. Section Abstract Doc Link 4056569 Disease Relevance 0.55 Pain Relevance 0.32
The results demonstrate that DFMO, an inhibitor of ODC, suppresses cell proliferation, whereas piroxicam, a NSAID, inhibits prostaglandins, and emphasize the need to develop agent-dependent intermediate biomarker(s) to validate the efficacy of chemopreventive agent(s) in colon carcinogenesis.
Negative_regulation (inhibitor) of ODC in colon associated with cinod
15) Confidence 0.53 Published 1992 Journal Carcinogenesis Section Abstract Doc Link 1600622 Disease Relevance 0 Pain Relevance 0.10
The effect of cocaine was independent of direct central actions, as introduction of the drug into the central compartment via intracisternal injection failed to inhibit ornithine decarboxylase.
Negative_regulation (inhibit) of ornithine decarboxylase associated with cocaine
16) Confidence 0.51 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1786562 Disease Relevance 0.17 Pain Relevance 0.81
Administration of 0.5 microgram of beta-endorphin alone significantly decreased brain and liver ODC activity 4 h after injection, and the effect was completely blocked by coinjection of CTOP (0.075 micrograms) but not by ICI-174,864 (0.75 or 3.75 micrograms) or beta-endorphin-(1-27) (3.75 or 7.5 micrograms).
Negative_regulation (decreased) of ODC in liver
17) Confidence 0.50 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.65
Our laboratory has previously shown that intracerebroventricular (i.c.v.) administration of beta-endorphin suppresses brain and liver ornithine decarboxylase activity (ODC; a growth regulatory enzyme) in preweanling rats.
Negative_regulation (suppresses) of ornithine decarboxylase in liver associated with intracerebroventricular
18) Confidence 0.50 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.40
Our laboratory has previously shown that intracerebroventricular (i.c.v.) administration of beta-endorphin suppresses brain and liver ornithine decarboxylase activity (ODC; a growth regulatory enzyme) in preweanling rats.
Negative_regulation (suppresses) of ODC in liver associated with intracerebroventricular
19) Confidence 0.50 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.40
The inhibition of the induction of ODC activity was accompanied by a reduction of ODC mRNA level and an acceleration of ODC turnover.
Negative_regulation (reduction) of ODC
20) Confidence 0.48 Published 1998 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9746211 Disease Relevance 0.08 Pain Relevance 0.44

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