INT118293

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.01
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
tongue 2
corneal epithelial cells 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 19 100.00 Very High Very High Very High
Inflammation 6 96.90 Very High Very High Very High
cINOD 34 96.24 Very High Very High Very High
local anesthetic 1 72.24 Quite High
Cancer pain 1 56.80 Quite High
COX2 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 5 98.64 Very High Very High Very High
Tongue Neoplasms 3 98.32 Very High Very High Very High
Lung Cancer 45 98.12 Very High Very High Very High
Colon Cancer 25 97.48 Very High Very High Very High
INFLAMMATION 8 96.90 Very High Very High Very High
Cancer 13 90.76 High High
Apoptosis 36 21.16 Low Low
Death 9 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effects of lidocaine (40-4000 microM) on proliferation of a human tongue cancer cell line, CAL27, which has a high level of EGFR expression, and also examined the effect of lidocaine on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR in CAL27 cells.
Spec (examined) Regulation (effect) of Phosphorylation (autophosphorylation) of EGFR in tongue associated with tongue neoplasms and lidocaine
1) Confidence 0.61 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551906 Disease Relevance 0.43 Pain Relevance 0.87
They cultured human corneal epithelial cells (HCECs) with EGF and lidocaine to investigate the effect of lidocaine on cell proliferation and on autophosphorylation of EGFR in HCECs.
Spec (investigate) Regulation (effect) of Phosphorylation (autophosphorylation) of EGFR in corneal epithelial cells
2) Confidence 0.61 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
To determine the effect of gefitinib on the phosphorylation status of EGFR, Ist-Mes-1, Ist-Mes-2 and MPP89, cells were seeded in T25 flask in full culture media for 24 h. 45 mins after the addition of gefitinib, EGF (final concentration 100 ng/ml) was added.
Spec (determine) Regulation (effect) of Phosphorylation (phosphorylation) of EGFR
3) Confidence 0.52 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.10 Pain Relevance 0
METHODS: To investigate the effect of lidocaine (4 microM-40 mM) on epidermal growth factor (EGF)-stimulated autophosphorylation of EGFR, the authors studied purified EGFR in microtubes.
Spec (investigate) Regulation (effect) of Phosphorylation (autophosphorylation) of EGFR
4) Confidence 0.45 Published 2004 Journal Anesthesiology Section Body Doc Link 15114219 Disease Relevance 0 Pain Relevance 0
NSAID, non-steroidal anti-inflammatory drug; CRC, colorectal cancer; ERK1/2, extracellular-signal regulated kinase; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; pEGFR, phosphorylated epidermal growth factor receptor; pERK1/2, phosphorylated extracellular-signal regulated kinase 1/2; COX, cyclooxygenase; FAP, familial adenomatous polyposis; FBS, fetal bovine serum; PBS, phosphate buffered saline; MAPK, mitogen-activated protein kinase; MEK1/2, mitogen-activated protein kinase kinase; MAb, monoclonal antibody; TKI, tyrosine kinase inhibitor; PI3-K, phosphatidylinositol-3-kinase; JAK/STAT, Janus kinase/signal transducers and activators of transcription; RTK, receptor tyrosine kinase



Regulation (regulated) of Phosphorylation (phosphorylated) of epidermal growth factor receptor associated with inflammation, familial adenomatous polyposis, colon cancer and cinod
5) Confidence 0.27 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.49 Pain Relevance 0.23

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