INT118305

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2003
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 6.52
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
plasma 2
sputum 2
plaque 2
heart 2
T lymphocytes 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 215 100.00 Very High Very High Very High
methotrexate 5 99.70 Very High Very High Very High
Pain 1 98.08 Very High Very High Very High
Inflammation 196 97.16 Very High Very High Very High
rheumatoid arthritis 8 96.60 Very High Very High Very High
antagonist 35 83.04 Quite High
Angina 21 77.68 Quite High
depression 3 64.72 Quite High
ischemia 17 64.08 Quite High
chemokine 35 61.84 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 65 99.84 Very High Very High Very High
Atherosclerotic Plaque 12 99.72 Very High Very High Very High
Cancer 20 99.48 Very High Very High Very High
Necrosis 28 99.20 Very High Very High Very High
Asthma 317 99.04 Very High Very High Very High
Acute Coronary Syndrome 52 98.96 Very High Very High Very High
Pain 1 98.08 Very High Very High Very High
INFLAMMATION 222 97.16 Very High Very High Very High
Rheumatoid Arthritis 8 96.60 Very High Very High Very High
Coronary Artery Disease 28 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results revealed that when IL-18 is over-expressed and TWEAK is inhibited by a specific neutralising antibody, an increase of TGF-?
Negative_regulation (inhibited) of Gene_expression (expressed) of IL-18
1) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.21 Pain Relevance 0.25
As for TWEAK, only addition of ethanolate produced an important IL-18 mRNA decrease (p?
Negative_regulation (decrease) of Gene_expression (produced) of IL-18
2) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.04
The combined endometrial IL-18 over-expression with a TWEAK inhibition increase cytotoxic receptors of uNK cells which produce massively pro-inflammatory cytokines like IFN?.
Negative_regulation (inhibition) of Gene_expression (expression) of IL-18 associated with inflammation and cytokine
3) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.28 Pain Relevance 0.27
Furthermore, IL-18 acts in synergy with IL-12 to promote the development of T helper 1 responses.55 Recently, increased IL-18 expression has been reported in human atherosclerotic plaque, mediating INF-?
Negative_regulation (reported) of Gene_expression (expression) of IL-18 in plaque associated with atherosclerotic plaque
4) Confidence 0.23 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.04 Pain Relevance 0.31
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of Gene_expression (levels) of IL-18 associated with methotrexate
5) Confidence 0.22 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.54 Pain Relevance 0.22
As plasma IL-18 levels decrease with improving clinical status, IL-18 can be used as a surrogate for guided therapy [27].
Negative_regulation (decrease) of Gene_expression (levels) of IL-18 in plasma
6) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.06 Pain Relevance 0.08
Moreover, IL-18 is raised in heart failure patients, in whom elevations correlate with poorer cardiac functional class and higher TNF-?
Negative_regulation (Moreover) of Neg (failure) Gene_expression (raised) of IL-18 in heart associated with myocardial infarction
7) Confidence 0.10 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.12 Pain Relevance 0.27
Decreased levels of IL-18 in sputum and BAL from asthmatic patients compared to normal controls have also been reported [248,249].
Negative_regulation (Decreased) of Gene_expression (levels) of IL-18 in sputum associated with asthma
8) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.69 Pain Relevance 0.26
After treating with ramipril, the levels of MCP-1 and IL-18 were decreased in elderly patients with ACS.
Negative_regulation (decreased) of Gene_expression (levels) of IL-18 associated with acute coronary syndrome
9) Confidence 0.08 Published 2010 Journal Heart Vessels Section Abstract Doc Link 20339966 Disease Relevance 1.03 Pain Relevance 0.15
Topical tacrolimus may inhibit local activation of T lymphocytes through altered expression of cytokines such as interleukin-1, -4 and -5, tumour necrosis factor-alpha and interferon-gamma.
Spec (may) Negative_regulation (inhibit) of Gene_expression (expression) of interleukin-1 in T lymphocytes associated with necrosis, cancer and cytokine
10) Confidence 0.03 Published 2004 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 15115509 Disease Relevance 0.54 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox