INT11831

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Context Info
Confidence 0.40
First Reported 1979
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 23.37
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
genitalium 1
reproductive organs 1
uterine 1
upper 1
pid (Mus musculus)
Pain Link Frequency Relevance Heat
pain pelvic 35 97.52 Very High Very High Very High
Inflammation 45 96.20 Very High Very High Very High
Pain 43 95.56 Very High Very High Very High
Dismenorea 59 83.96 Quite High
abdominal pain 17 81.36 Quite High
Dysuria 12 57.44 Quite High
depression 3 41.12 Quite Low
endometriosis 38 5.00 Very Low Very Low Very Low
backache 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chlamydia Infection 433 100.00 Very High Very High Very High
Reprotox - General 3 127 100.00 Very High Very High Very High
Pelvic Infection 11 100.00 Very High Very High Very High
Death 4 99.92 Very High Very High Very High
Infection 103 99.76 Very High Very High Very High
Sexually Transmitted Diseases 9 99.70 Very High Very High Very High
Disease 35 99.16 Very High Very High Very High
Gonorrhea 21 99.14 Very High Very High Very High
Reprotox - General 2 90 97.44 Very High Very High Very High
Abscess 5 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The physicians responsibility is 1) to give formal and extensive recognition to the connection that IUD uses causes PID; 2) to inform patients of the potential risk of PID and sterility; 3) to develop proper patient selection for an IUD; 4) to identify and treat PID, which may appear initially as abnormal uterine bleeding and mild pain; 5) to recognize that the IUD facilitates the development of PID in patients with Neisseria gonorrhoea and Chlamydia trachomatis even though 25-50% of IUD patients have neither infection; 6) to recognize that the risk of PID is increased in the first 4-6 months of insertion and to research alternatives, e.g. the use of available antibiotics to treat selected patients to reduce infections, and 7) to realize that most PID occurs 6 months after insertion and indolent abscess formation is expected to increase among longterm copper IUD users.
Positive_regulation (increased) of PID in uterine associated with uterine hemorrhage, pain, infertility, gonorrhea, abscess, chlamydia infection and infection
1) Confidence 0.40 Published 1992 Journal Fertil. Steril. Section Abstract Doc Link 1601138 Disease Relevance 1.95 Pain Relevance 0.13
Women in this study who were found to have PID were given postoperative antibiotics.
Positive_regulation (have) of PID associated with chlamydia infection
2) Confidence 0.40 Published 1979 Journal J Obstet Gynaecol India Section Abstract Doc Link 12339215 Disease Relevance 1.24 Pain Relevance 0.12
IUD use greatly increases the risk of PID, probably because of the avenue the device provides for organisms to ascend from the lower to the upper genital tract.
Spec (probably) Positive_regulation (increases) of PID in upper associated with chlamydia infection
3) Confidence 0.40 Published 1984 Journal Res Front Fertil Regul Section Abstract Doc Link 12179634 Disease Relevance 1.63 Pain Relevance 0.14
PID is caused when infection-producing organisms spread upwards from the vagina through the cervix to the upper reproductive organs.
Positive_regulation (caused) of PID in reproductive organs associated with chlamydia infection and infection
4) Confidence 0.40 Published 1996 Journal BETA Section Abstract Doc Link 11363314 Disease Relevance 1.75 Pain Relevance 0.20
Untreated sexually transmitted diseases are a leading cause of PID.
Positive_regulation (cause) of PID associated with sexually transmitted diseases and chlamydia infection
5) Confidence 0.40 Published 1996 Journal BETA Section Abstract Doc Link 11363314 Disease Relevance 1.86 Pain Relevance 0.22
Neisseria gonorrhoeae and Chlamydia trachomatis are the primary causes of PID.
Positive_regulation (causes) of PID associated with gonorrhea and chlamydia infection
6) Confidence 0.40 Published 1993 Journal Postgrad Med Section Abstract Doc Link 8433960 Disease Relevance 2.09 Pain Relevance 0.18
This review of the literature suggests that all types of IUDs in use have the potential to enhance PID.
Positive_regulation (enhance) of PID associated with chlamydia infection
7) Confidence 0.40 Published 1983 Journal Conn Med Section Abstract Doc Link 6851548 Disease Relevance 0.47 Pain Relevance 0.05
A significant increase in PID is also reported for women who use the device for more than 5 years.
Positive_regulation (increase) of PID associated with pelvic infection
8) Confidence 0.40 Published 1986 Journal Minerva Ginecol Section Abstract Doc Link 3808430 Disease Relevance 1.25 Pain Relevance 0.21
Bacterial vaginosis-associated organisms have been associated with PID,9 10 and because M genitalium is associated with cervicitis4 5 it is reasonable to hypothesise that it also causes PID.
Positive_regulation (causes) of PID in genitalium associated with bacterial vaginosis and chlamydia infection
9) Confidence 0.38 Published 2008 Journal Sexually Transmitted Infections Section Body Doc Link PMC2572206 Disease Relevance 2.11 Pain Relevance 0.08
Additionally, our data did not allow us to include missed cases of PID, as the extracted electronic medical records of the 189 patients only included diagnosed cases of PID that were based on the ICD codes.
Positive_regulation (cases) of PID associated with chlamydia infection
10) Confidence 0.37 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1624808 Disease Relevance 0.96 Pain Relevance 0.08
In contrast, a study from the U.K. found that the rates of gonococcal PID were increasing [22].
Positive_regulation (increasing) of PID associated with chlamydia infection
11) Confidence 0.34 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1624808 Disease Relevance 0.73 Pain Relevance 0
PID is a relatively common disease; in the U.S. around 8% of all women will have PID during their reproductive period [2], and in the U.K.
Positive_regulation (have) of PID associated with disease and chlamydia infection
12) Confidence 0.34 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1624808 Disease Relevance 1.44 Pain Relevance 0.05
In most cases of PID, treatment can be administered without removal of the device.52,53
Positive_regulation (cases) of PID associated with chlamydia infection
13) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971715 Disease Relevance 1.25 Pain Relevance 0
One of the most persistent questions about IUDs is whether they increase the risk of PID.
Spec (whether) Positive_regulation (increase) of PID associated with chlamydia infection
14) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971715 Disease Relevance 0.89 Pain Relevance 0.05
A comparative study of the LNG-IUS versus the Nova-T copper IUD noted significantly lower rates of PID among LNG-IUS users at 3 and 5 years of follow-up.48 A second trial comparing the LNG-IUS and the copper T 380A IUD showed low terminations rates for PID/endometritis (0.7 per 100 years) with both devices.49
Positive_regulation (rates) of PID associated with reprotox - general 2 and chlamydia infection
15) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971715 Disease Relevance 1.27 Pain Relevance 0.03
A woman who currently has an STI such as gonorrhea or chlamydia or is at very high risk should not have an IUD inserted as insertion may increase the risk of PID.
Positive_regulation (increase) of PID associated with reprotox - general 3, gonorrhea and chlamydia infection
16) Confidence 0.03 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770406 Disease Relevance 1.09 Pain Relevance 0
However, whether IUDs increase the risk of PID in women with an STI at the time of insertion is not known (Mohllajee et al 2006).


Spec (whether) Positive_regulation (increase) of PID associated with reprotox - general 3
17) Confidence 0.03 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770406 Disease Relevance 1.38 Pain Relevance 0

General Comments

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