INT118319

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.43
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp)
Anatomy Link Frequency
ARC 1
neurons 1
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 16 99.98 Very High Very High Very High
Neuropeptide 146 99.86 Very High Very High Very High
antagonist 4 99.54 Very High Very High Very High
Kappa opioid receptor 1 99.12 Very High Very High Very High
Endogenous opioid 2 98.60 Very High Very High Very High
narcan 2 98.56 Very High Very High Very High
Enkephalin 3 97.96 Very High Very High Very High
Opioid 6 96.52 Very High Very High Very High
agonist 9 96.08 Very High Very High Very High
Cannabinoid 5 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 3 99.68 Very High Very High Very High
Weight Gain 5 95.28 Very High Very High Very High
Infection 12 85.92 High High
INFLAMMATION 5 85.92 High High
Weight Loss 3 85.68 High High
Appetite Loss 45 85.16 High High
Hypertriglyceridemia 4 75.92 Quite High
Chronic Disease 4 74.08 Quite High
Sepsis 1 58.40 Quite High
Cancer 5 56.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-MSH is increased and the secretion of AGRP is decreased from hypothalamic explants in response to IL1?
Localization (secretion) of AGRP
1) Confidence 0.65 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.79 Pain Relevance 0.28
The inhibitory effect of rimonabant was also prevented by naloxone and a kappa-opioid receptor selective antagonist, suggesting that GABA release from arcuate NPY/AgRP/GABA neurones can be inhibited by endogenous opioid peptides, and that the release of opioid peptides is sensitive to cannabinoids.
Localization (release) of AgRP associated with gaba, cannabinoid, antagonist, endogenous opioid, kappa opioid receptor, narcan and opioid
2) Confidence 0.63 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0 Pain Relevance 1.54
In order to determine the amount of secreted AgRP protein, supernatants were analyzed on a spot blot (data not shown).
Spec (determine) Localization (secreted) of AgRP protein
3) Confidence 0.38 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.03
We compared the localization of AgRP in primary cortical neurons which were infected with AAV-flAgRP or AAV-VWF-AgRP83-132 to check if AAV-VWF-AgRP83-132 entered the regulated secretion pathway.
Localization (localization) of AgRP in neurons
4) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0.09 Pain Relevance 0
We used the cDNA of AgRP83-132 as a minigene, because this is the main secreted form of AgRP after processing by PC [22].
Localization (secreted) of AgRP
5) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.16
This blot showed that 18.2-fold less AgRP was secreted from the VWF-AgRP83-132 transfected cells compared to flAgRP transfected cells, even though the transfection efficiencies were similar.
Localization (secreted) of AgRP
6) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.03
It was not seen, however, for neuropeptide Y and agouti-related protein localized in the ARC, which are unaffected or reduced by dietary fat.
Localization (localized) of agouti-related protein in ARC associated with aids-related complex and neuropeptide
7) Confidence 0.22 Published 2004 Journal Endocrinology Section Abstract Doc Link 15117877 Disease Relevance 0.55 Pain Relevance 0.32

General Comments

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