INT118343

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 121
Total Number 128
Disease Relevance 136.06
Pain Relevance 34.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 12
spinal cord 8
brain 6
Th17 cells 4
leukocyte 3
Eae1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 3113 100.00 Very High Very High Very High
Spinal cord 1280 100.00 Very High Very High Very High
Inflammatory mediators 47 100.00 Very High Very High Very High
nav1.8 10 100.00 Very High Very High Very High
chemokine 1047 99.92 Very High Very High Very High
Central nervous system 2333 99.88 Very High Very High Very High
b2 receptor 289 99.82 Very High Very High Very High
withdrawal 12 99.64 Very High Very High Very High
Inflammation 2757 99.62 Very High Very High Very High
dexamethasone 68 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 10883 100.00 Very High Very High Very High
Demyelinating Disease 1988 100.00 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 37 100.00 Very High Very High Very High
INFLAMMATION 2931 99.98 Very High Very High Very High
Disease 2492 99.96 Very High Very High Very High
Stress 899 99.92 Very High Very High Very High
Immunization 391 99.84 Very High Very High Very High
Central Nervous System Disease 788 99.68 Very High Very High Very High
Sprains And Strains 323 99.66 Very High Very High Very High
Targeted Disruption 521 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if changes in nociception were due to direct effects of encephalitogenic T cells, nociceptive responses in female SJL mice were measured following the transfer of activated, PLP(139-151) specific T cells to induce 'passive' EAE.
Positive_regulation (induce) of EAE in T cells associated with nociception and multiple sclerosis
1) Confidence 0.39 Published 2004 Journal Pain Section Abstract Doc Link 15288396 Disease Relevance 2.27 Pain Relevance 0.94
In both active and passive EAE, there was an initial increase in tail withdrawal latency (hypoalgesia) that peaked several days prior to the peak in motor deficits during the acute disease phase.
Positive_regulation (increase) of EAE in tail associated with multiple sclerosis, acute disease, hypoalgesia and withdrawal
2) Confidence 0.39 Published 2004 Journal Pain Section Abstract Doc Link 15288396 Disease Relevance 2.36 Pain Relevance 1.07
To determine whether EAE is an appropriate model for MS-related pain, nociceptive responses in both male and female SJL mice were measured before and after immunization with myelin proteolipid protein peptide 139-151 (PLP(139-151)) in complete Freund's adjuvant to induce 'active' EAE.
Positive_regulation (induce) of EAE associated with nociception, pain, multiple sclerosis and immunization
3) Confidence 0.39 Published 2004 Journal Pain Section Abstract Doc Link 15288396 Disease Relevance 2.16 Pain Relevance 0.88
ligand-treated EAE) mice were anaesthetized with isoflurane and then mounted in a stereotaxic apparatus on Days 28–29 post EAE induction.
Positive_regulation (induction) of EAE associated with multiple sclerosis and isoflurane
4) Confidence 0.28 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.20 Pain Relevance 0.18
(B) Quantification of number of CD45+, Mac3+ and CD3+ cells and the relative fluorescence intensity of glial fibrillary acidic protein immunostaining demonstrated an increase in both vehicle-treated EAE and oestrogen receptor ?
Positive_regulation (increase) of EAE associated with multiple sclerosis
5) Confidence 0.28 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.94 Pain Relevance 0.14
Although the pathophysiological basis for these deficits is not clear, it was recently reported that the expression of the sensory neuron-specific sodium channel Nav1.8 (which is not normally expressed within the cerebellum) is aberrantly upregulated within Purkinje cells in experimental allergic encephalomyelitis (EAE) and in human MS.
Positive_regulation (upregulated) of EAE in sensory neuron associated with multiple sclerosis, sodium channel, nav1.8 and experimental autoimmune encephalomyelitis
6) Confidence 0.24 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15118796 Disease Relevance 0.61 Pain Relevance 0.49
Our results demonstrate a reduction in the number of secondary spikes per complex spike and irregularity in the temporal organization of secondary spikes in Purkinje cells from mice with EAE in which Nav1.8 is upregulated.
Positive_regulation (upregulated) of EAE in Purkinje cells associated with multiple sclerosis and nav1.8
7) Confidence 0.24 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15118796 Disease Relevance 0.84 Pain Relevance 0.60
"Sham animals" refers to WT animals without EAE induction.


Neg (without) Positive_regulation (induction) of EAE associated with multiple sclerosis
8) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.09 Pain Relevance 0.04
EAE induction
Positive_regulation (induction) of EAE associated with multiple sclerosis
9) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.89 Pain Relevance 0.37
expression after EAE induction.
Positive_regulation (induction) of EAE associated with multiple sclerosis
10) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.00 Pain Relevance 0.36
In the present experiments, CCL2 levels were lower in B2-/- mice than in WT mice after EAE induction.
Positive_regulation (induction) of EAE associated with multiple sclerosis
11) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.06 Pain Relevance 0.21
Considering previous data, it may be possible that kinin receptors could be regulating the expression of chemokines and, consequently, leukocyte trafficking after EAE induction.
Positive_regulation (induction) of EAE in leukocyte associated with chemokine and multiple sclerosis
12) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.73 Pain Relevance 0.64
EAE induction enhanced cerebral production of the chemokines CCL2 and CCL5 in WT mice (Figure 4A, B).
Positive_regulation (induction) of EAE associated with chemokine and multiple sclerosis
13) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.06 Pain Relevance 0.27
Vehicle-treated EAE and oestrogen receptor ?
Positive_regulation (treated) of EAE associated with multiple sclerosis
14) Confidence 0.20 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 1.05 Pain Relevance 0.13
ms) for normal, vehicle-treated EAE and oestrogen receptor ?
Positive_regulation (treated) of EAE associated with multiple sclerosis
15) Confidence 0.20 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.38 Pain Relevance 0.19
ligand or vehicle treatment was administered in ovariectomized mice every other day, starting 1 week prior to active EAE induction.
Positive_regulation (induction) of EAE associated with multiple sclerosis
16) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.93 Pain Relevance 0.04
ligand-treated EAE had an increase in the total number of infiltrating cells (represented by DAPI+ cells) after induction of EAE.
Positive_regulation (induction) of EAE associated with multiple sclerosis
17) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 1.35 Pain Relevance 0.16
ligand treatment before active EAE induction is directly neuroprotective since it preserved spinal cord myelin and prevented axonal loss without reducing CNS inflammation (Tiwari-Woodruff et al., 2007).
Positive_regulation (induction) of EAE in spinal cord associated with multiple sclerosis, inflammation and spinal cord
18) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.92 Pain Relevance 0.35
ligand treatment effects on demyelination and axon degeneration, active EAE was induced in PLP-EGFP transgenic C57BL/6 mice (Mallon et al., 2002).
Positive_regulation (induced) of EAE associated with targeted disruption, multiple sclerosis and demyelination
19) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.76 Pain Relevance 0.05
We have routinely induced chronic EAE in female C57BL/6 mice (Morales et al., 2006; Tiwari-Woodruff et al., 2007).
Positive_regulation (induced) of EAE associated with multiple sclerosis
20) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 1.06 Pain Relevance 0

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