INT118368

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.80
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
NG108-15 2
hepatocytes 1
lung 1
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta opioid receptors 2 99.00 Very High Very High Very High
Opioid 2 95.32 Very High Very High Very High
qutenza 130 93.28 High High
opioid receptor 2 90.08 High High
Paracetamol 2 82.56 Quite High
MU agonist 2 75.00 Quite High
metalloproteinase 1 44.64 Quite Low
aspirin 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 10 98.72 Very High Very High Very High
Small Cell Lung Cancer 63 73.04 Quite High
Cancer 130 69.68 Quite High
Repression 6 45.20 Quite Low
Targeted Disruption 6 20.04 Low Low
Apoptosis 14 9.40 Low Low
Injury 1 8.84 Low Low
Metastasis 19 5.00 Very Low Very Low Very Low
Wound Healing 11 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription factors, E2F1 and ID1 mRNA were increased three-fold and six-fold (P < 0.05, P < 0.01), respectively, in AFB(1) treated primary human hepatocytes but were not altered in HepG2.
Positive_regulation (increased) of E2F1 in hepatocytes
1) Confidence 0.69 Published 2004 Journal Mutat. Res. Section Abstract Doc Link 15120964 Disease Relevance 0 Pain Relevance 0.15
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
Positive_regulation (levels) of E2F1 in NG108-15 associated with delta opioid receptors
2) Confidence 0.58 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
To elucidate E2F-1's function, searching for E2F-1's bona fide targets has been extensively conducted.
Positive_regulation (elucidate) of E2F-1
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.19 Pain Relevance 0
The results indicted that E2F-1 response elements were located in the region between ?
Positive_regulation (elements) of E2F-1
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
These observations suggested that the DNA binding activity of E2F1 is required for inducing TSP1 expression.
Positive_regulation (required) of E2F1
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In addition, in order to test whether pRB1 could affect the transactivation of E2F-1 on TSP1 promoter, we transfected two different dosage of HA-tagged pRB1 (0.2µg and 0.5µg/per well in 24-well plates) together with HA-tagged E2F-1(0.2 µg/per well in 24-well plates) and performed promoter assays, pRB1 could indeed suppress the transactivity of E2F-1 on TSP1 promoter in a dose-dependent manner (Fig. 2H), which is consistent with the effect of pRB1 on other bona fide targets of E2F-1.
Positive_regulation (transactivation) of E2F-1
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In order to define the response elements in TSP1 promoter for E2F-1 up-regulation, initially, we did fine mapping for TSP1 promoter.
Positive_regulation (up-regulation) of E2F-1
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
Positive_regulation (increased) of E2F1 in NG108-15 associated with delta opioid receptors
8) Confidence 0.39 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
Data obtained from microarrays, tissue samples from lung cancer patients and human lung cancer cell lines indicate that cell cycle regulatory molecules, like E2F1–5, p130, Skp2, cyclin D1 and p16, contribute to the growth and progression of lung tumors [33].
Positive_regulation (contribute) of E2F1 in lung associated with lung cancer
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.60 Pain Relevance 0.45
Similarly, the E2F1 promoter was found to contain two putative Tcf-binding elements, and promoter activity is inhibited by overexpression of ?
Positive_regulation (found) of E2F1
10) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0

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