INT118370

Context Info Confidence 0.45 First Reported 2004 Last Reported 2005 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 0.58 Pain Relevance 0.16

nucleus (ID1) cytoplasm (ID1)

Anatomy Link Frequency hepatocytes 1 epithelial cells 1 ID1 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 6 92.56 Inflammation 8 32.92 psoriasis 12 5.00 metalloproteinase 8 5.00 withdrawal 8 5.00 cytokine 4 5.00 antagonist 4 5.00

Disease Link Frequency Relevance Heat Ovarian Cancer 4 96.16 Aging 4 94.40 Psoriasis 20 82.88 Cancer 92 75.00 Colorectal Cancer 4 70.92 Adhesions 8 54.08 Apoptosis 32 44.32 Colon Cancer 32 42.84 Leukemia 4 41.92 Disease 4 40.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The transcription factors, E2F1 and ID1 mRNA were increased three-fold and six-fold (P < 0.05, P < 0.01), respectively, in AFB(1) treated primary human hepatocytes but were not altered in HepG2.

Neg (not) Regulation (altered) of ID1 in hepatocytes

1) Confidence 0.45 Published 2004 Journal Mutat. Res. Section Abstract Doc Link 15120964 Disease Relevance 0 Pain Relevance 0.16

Vitamin D is also known to promote differentiation and was shown by others to down-regulate ID-1 through a suppressive vitamin D response sequence in the 5'of the gene [18].

Regulation (regulate) of ID-1

2) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.27 Pain Relevance 0

Interestingly, significant transcriptional down-regulation of the inhibitor of differentiation 1 (ID-1) was found at 1 hr in both Caco-2 and NHEK, suggesting a common mechanism of NAC induced differentiation and inhibition of proliferation in NHEK and Caco-2 epithelial cells.

Regulation (regulation) of ID-1 in epithelial cells

3) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0 Pain Relevance 0

This correlates well with our results on repressed ID-1 expression, since both BMP-2 and -4 up-regulate ID-1 [64,65].

Regulation (regulate) of ID-1

4) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.12 Pain Relevance 0

Only one gene, ID-1, was mutually regulated at 1 hour post treatment and might represent a common mediator of early NAC action.

Regulation (regulated) of ID-1

5) Confidence 0.19 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1182358 Disease Relevance 0.18 Pain Relevance 0

General Comments

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