INT118370

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.58
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ID1) cytoplasm (ID1)
Anatomy Link Frequency
hepatocytes 1
epithelial cells 1
ID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 92.56 High High
Inflammation 8 32.92 Quite Low
psoriasis 12 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 4 96.16 Very High Very High Very High
Aging 4 94.40 High High
Psoriasis 20 82.88 Quite High
Cancer 92 75.00 Quite High
Colorectal Cancer 4 70.92 Quite High
Adhesions 8 54.08 Quite High
Apoptosis 32 44.32 Quite Low
Colon Cancer 32 42.84 Quite Low
Leukemia 4 41.92 Quite Low
Disease 4 40.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription factors, E2F1 and ID1 mRNA were increased three-fold and six-fold (P < 0.05, P < 0.01), respectively, in AFB(1) treated primary human hepatocytes but were not altered in HepG2.
Neg (not) Regulation (altered) of ID1 in hepatocytes
1) Confidence 0.45 Published 2004 Journal Mutat. Res. Section Abstract Doc Link 15120964 Disease Relevance 0 Pain Relevance 0.16
Vitamin D is also known to promote differentiation and was shown by others to down-regulate ID-1 through a suppressive vitamin D response sequence in the 5'of the gene [18].
Regulation (regulate) of ID-1
2) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.27 Pain Relevance 0
Interestingly, significant transcriptional down-regulation of the inhibitor of differentiation 1 (ID-1) was found at 1 hr in both Caco-2 and NHEK, suggesting a common mechanism of NAC induced differentiation and inhibition of proliferation in NHEK and Caco-2 epithelial cells.
Regulation (regulation) of ID-1 in epithelial cells
3) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0 Pain Relevance 0
This correlates well with our results on repressed ID-1 expression, since both BMP-2 and -4 up-regulate ID-1 [64,65].
Regulation (regulate) of ID-1
4) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.12 Pain Relevance 0
Only one gene, ID-1, was mutually regulated at 1 hour post treatment and might represent a common mediator of early NAC action.
Regulation (regulated) of ID-1
5) Confidence 0.19 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1182358 Disease Relevance 0.18 Pain Relevance 0

General Comments

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