INT118381

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2004
Last Reported 2011
Negated 10
Speculated 13
Reported most in Body
Documents 405
Total Number 418
Disease Relevance 306.97
Pain Relevance 112.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
T cells 110
Th17 cells 31
synovium 16
joint 10
lymphocytes 9
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 12570 100.00 Very High Very High Very High
cytokine 8235 100.00 Very High Very High Very High
Inflammation 5405 100.00 Very High Very High Very High
Arthritis 3759 100.00 Very High Very High Very High
chemokine 995 100.00 Very High Very High Very High
addiction 32 99.92 Very High Very High Very High
spinal inflammation 110 99.84 Very High Very High Very High
abatacept 122 99.68 Very High Very High Very High
Sciatic nerve 8 99.60 Very High Very High Very High
psoriasis 1111 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 12710 100.00 Very High Very High Very High
Infection 6583 100.00 Very High Very High Very High
INFLAMMATION 5708 100.00 Very High Very High Very High
Sprains And Strains 3694 100.00 Very High Very High Very High
Arthritis 3466 100.00 Very High Very High Very High
Cancer 827 100.00 Very High Very High Very High
Necrosis 497 100.00 Very High Very High Very High
Lyme Disease 161 99.98 Very High Very High Very High
Synovitis 280 99.96 Very High Very High Very High
Disease 7592 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a crucial role of T cell inflammation, RAG-1 knockout mice lacking functional T lymphocytes did not express IL-17A mRNA in distal nerve segments following CCI.
Neg (not) Gene_expression (express) of IL-17A mRNA in nerve associated with targeted disruption, inflammation and eae
1) Confidence 0.76 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 1.01 Pain Relevance 0.81
T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression.
Gene_expression (expression) of interleukin-17 in T cell associated with eae, injury and sciatic nerve
2) Confidence 0.76 Published 2006 Journal Exp. Neurol. Section Title Doc Link 16674943 Disease Relevance 0.95 Pain Relevance 0.73
In the present investigation, we analyzed the temporal gene expression pattern of IL-17A and its main regulators IL-23 and IL-15 after chronic constriction injury (CCI) of the sciatic nerve, a lesion paradigm inducing neuropathic pain, by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in mice.
Spec (analyzed) Gene_expression (expression) of IL-17A in sciatic nerve associated with eae, injury, neuropathic pain and sciatic nerve
3) Confidence 0.76 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.74 Pain Relevance 0.51
Accordingly, IL-17A positive T cells were detectable within the endoneurium of the injured nerves by immunocytochemistry.
Gene_expression (detectable) of IL-17A in nerves
4) Confidence 0.76 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.99 Pain Relevance 0.78
Taken together, these observations provide evidence that IL-17A is indeed produced in the lungs in response to inhalational LVS infection, and in accordance with other observations [30], [34]–[35].
Gene_expression (produced) of IL-17A in lungs associated with sprains and strains and infection
5) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.04 Pain Relevance 0.19
To evaluate the contribution of the various pulmonary T-cell populations to the net production of IL-17A, the actual number of the relevant cells (CD4+ and ??
Gene_expression (production) of IL-17A in T-cell
6) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.68 Pain Relevance 0
T cells are non-essential (Figure 7), it could be speculated that other cellular sources of IL-17A, such as Th17 -cells (Figure 5), produce sufficient amounts of IL-17A to resolve the low-dose infection.
Gene_expression (produce) of IL-17A in T cells associated with infection
7) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.14 Pain Relevance 0.12
The expression of IL-17A was mostly below detection threshold in the non-lymphocyte cells (determined as all of the cells that were not included in the Lymphocyte Gate) throughout the course of infection (Figure 6A).
Gene_expression (expression) of IL-17A in Lymphocyte associated with infection
8) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.56 Pain Relevance 0
Production of IL-17A in the lungs following intranasal infection with LVS
Gene_expression (Production) of IL-17A in lungs associated with sprains and strains and infection
9) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.30 Pain Relevance 0.18
Intranasal infection with LVS, which induces IL-17A expression in pulmonary lymphocytes (Figure 3), entailed accumulation of IL-17A in the BALF (Figure 4A left) that reached its peak in days 3–4.
Gene_expression (expression) of IL-17A in lymphocytes associated with sprains and strains and infection
10) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.54 Pain Relevance 0.08
Thus, these results indicate that the IL-17A detected in BALF may be mostly attributed to lymphocytes.
Gene_expression (detected) of IL-17A in lymphocytes
11) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.73 Pain Relevance 0
Results suggest that CD4+ cells are the major contributors to IL-17A production in infected LVS lungs, yet ??
Gene_expression (production) of IL-17A in lungs associated with sprains and strains
12) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.54 Pain Relevance 0
We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary ??
Gene_expression (production) of IL-17A in lymphocytes
13) Confidence 0.72 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2887844 Disease Relevance 1.25 Pain Relevance 0
Here we provide comprehensive accurate data on the kinetics of the IL-17-mediated response, including the production of IL-17A in the lungs and the identity of the lymphocyte sources for IL-17A, with regard to sub-lethal and lethal infective doses.
Gene_expression (production) of IL-17A in lymphocyte
14) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.88 Pain Relevance 0.11
The contribution of various pulmonary T-cell subpopulations to production of IL-17A
Gene_expression (production) of IL-17A in T-cell
15) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.71 Pain Relevance 0
CD8+ T cells failed to produce IL-17A even at the high infection dose (Figure 5, B1).
Neg (failed) Gene_expression (produce) of IL-17A in T cells associated with infection
16) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.69 Pain Relevance 0.03
IL-17A was detected only in some cells within the Lymphocyte Gate, an expression that increased during the course of infection (Figure 6A).
Gene_expression (detected) of IL-17A in Lymphocyte associated with infection
17) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.73 Pain Relevance 0
and IL-6, the production of IL-17A could not be further induced by infection doses beyond 10×LD50.


Gene_expression (production) of IL-17A associated with infection
18) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.13 Pain Relevance 0.20
Remarkably, a robust and early induction of IL-17A production by ??
Gene_expression (production) of IL-17A
19) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.63 Pain Relevance 0.07
Intranasal LVS infection triggers a robust production of IL-17A by specific pulmonary T cell subpopulations
Gene_expression (production) of IL-17A in T cell associated with sprains and strains and infection
20) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.08 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox