INT118388

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Context Info
Confidence 0.81
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 40
Total Number 41
Disease Relevance 9.59
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2) nucleus (Nfe2l2) DNA binding (Nfe2l2)
cytoplasm (Nfe2l2)
Anatomy Link Frequency
nucleus 8
hepatocytes 2
respiratory 2
neuronal 1
liver 1
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 75 99.56 Very High Very High Very High
withdrawal 3 98.68 Very High Very High Very High
qutenza 33 98.02 Very High Very High Very High
anesthesia 4 97.00 Very High Very High Very High
Migraine 3 96.60 Very High Very High Very High
cINOD 17 86.32 High High
Inflammation 222 82.72 Quite High
Glutamate 15 79.44 Quite High
Central grey 3 79.28 Quite High
Central nervous system 6 77.20 Quite High
Disease Link Frequency Relevance Heat
Stress 436 99.96 Very High Very High Very High
Cancer 115 99.76 Very High Very High Very High
Injury 58 99.12 Very High Very High Very High
Parkinson's Disease 1 98.62 Very High Very High Very High
Inflammatory Bowel Disease 96 97.96 Very High Very High Very High
Toxicity 142 97.56 Very High Very High Very High
Shock 8 96.88 Very High Very High Very High
Headache 3 96.60 Very High Very High Very High
Stroke 3 96.04 Very High Very High Very High
Hepatotoxicity 11 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During periods of oxidative stress, Nrf2 is released from sequestration in the cytoplasm and translocates to the nucleus.
Localization (translocates) of Nrf2 in nucleus associated with stress
1) Confidence 0.81 Published 2007 Journal Toxicol Pathol Section Abstract Doc Link 17562481 Disease Relevance 0.35 Pain Relevance 0.06
During periods of oxidative stress, Nrf2 is released from sequestration in the cytoplasm and translocates to the nucleus.
Localization (released) of Nrf2 in nucleus associated with stress
2) Confidence 0.81 Published 2007 Journal Toxicol Pathol Section Abstract Doc Link 17562481 Disease Relevance 0.29 Pain Relevance 0.06
We show that acetaminophen can initiate nuclear translocation of Nrf2 in vivo, with maximum levels reached after 1 hour, in a dose dependent manner, at doses below those causing overt liver damage.
Localization (translocation) of Nrf2 in liver associated with paracetamol and hepatotoxicity
3) Confidence 0.80 Published 2004 Journal Hepatology Section Abstract Doc Link 15122755 Disease Relevance 0.27 Pain Relevance 0.40
For each compound, greater than 60% depletion of GSH was achieved; however, in the case of BSO, this depletion did not cause nuclear translocation of Nrf2.
Localization (translocation) of Nrf2
4) Confidence 0.80 Published 2004 Journal Hepatology Section Abstract Doc Link 15122755 Disease Relevance 0.12 Pain Relevance 0.36
Although exposure of hepatocytes to nimesulide was not associated with increased net levels of superoxide anion, nimesulide (100 microM, 24 h) caused nuclear translocation of Nrf2 in a sulfaphenazole-sensitive manner, indicating a role of electrophilic metabolites.
Localization (translocation) of Nrf2 in hepatocytes
5) Confidence 0.80 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.65 Pain Relevance 0.07
Nrf2 was found only in oligemia mice and was localized in neurons of the cingulate cortex and cerebellar Purkinje cells.
Localization (localized) of Nrf2 in cingulate cortex
6) Confidence 0.77 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.47 Pain Relevance 0.26
Here, we have investigated, in vivo, whether the ability of four murine hepatotoxins, paracetamol, bromobenzene (BB), carbon tetrachloride (CCl4) and furosemide (FS) to deplete hepatic glutathione (GSH) is related to induction of hepatic Nrf2 nuclear translocation and Nrf2-dependent gene expression.
Localization (translocation) of Nrf2 associated with paracetamol
7) Confidence 0.75 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.14 Pain Relevance 0.47
Additionally, we studied whether hepatic Nrf2 nuclear translocation is a general response during the early stages of acute hepatic chemical stress in vivo.
Spec (whether) Localization (translocation) of Nrf2 associated with stress
8) Confidence 0.75 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.16 Pain Relevance 0.53
We demonstrate that Keap1/Nrf2 and NF-kappaB respond differently to electrophiles that bind proteins covalently and the redox perturbation associated with glutathione depletion, and that crosstalk may enable NF-kappaB to partly influence Nrf2 expression during cellular stress.
Localization (respond) of Nrf2 associated with stress
9) Confidence 0.71 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.48 Pain Relevance 0.10
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.
Localization (response) of Nrf2
10) Confidence 0.71 Published 2010 Journal Biochem. Pharmacol. Section Title Doc Link 20416283 Disease Relevance 0.40 Pain Relevance 0.10
The Benjamini–Hochberg cut-off was set at 0.2 to avoid the exclusion of correlated Nrf2-regulated proteins through application of too stringent a correction for multiple testing in accordance with multivariate modelling approaches to account for potential confounders [47].

2DE gel data

Localization (exclusion) of Nrf2
11) Confidence 0.71 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0 Pain Relevance 0
Similarly, exposure of wild-type C57BL/6x129 Sv mice to nimesulide (100 mg/kg/day, po, for 5 days) was associated with nuclear translocation of immunoreactive Nrf2 in a small number of hepatocytes and induced >2-fold the expression levels of the Nrf2-target gene Nqo1 in wild-type but not Nrf2-null mice.
Localization (translocation) of Nrf2 in hepatocytes
12) Confidence 0.70 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.70 Pain Relevance 0.05
Response of the brain to oligemia: gene expression, c-Fos, and Nrf2 localization.
Localization (localization) of Nrf2 in brain
13) Confidence 0.67 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15207916 Disease Relevance 0.48 Pain Relevance 0.26
Using immunohistochemistry, we localized the transcription factors Nrf2, which regulates expression of antioxidant and detoxification protein, and c-Fos, a marker of neuronal activation.
Localization (localized) of Nrf2 in neuronal
14) Confidence 0.67 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.45 Pain Relevance 0.27
Once translocated to the nucleus, NRF2 forms heterodimers with other transcriptional regulators such as c-Jun, JunB/D, ATF2/4, or MAF F/G/K (15–17).
Localization (translocated) of NRF2 in nucleus
15) Confidence 0.65 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.27 Pain Relevance 0.07
Previous studies and our current studies found that KEAP1 interacts only with the most N-terminal region of NRF2 (data not shown) (29).
Localization (region) of NRF2
16) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
A second notable difference between KEAP1 and CRIF1 negative regulation of NRF2 is that KEAP1 can bind to, ubiquitinate, and drive proteasomal degradation of full-length NRF2 only at the N-terminal region of NRF2, whereas CRIF1 can bind and ubiquitinate and may drive proteasomal degradation of full-length NRF2 through both ends of the protein.
Localization (regulation) of NRF2
17) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.60 Pain Relevance 0
In our cell-based model, we have shown that depletion of GSH by BSO induces the nuclear accumulation of Nrf2 and increases NF-?
Localization (accumulation) of Nrf2
18) Confidence 0.61 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0 Pain Relevance 0
On the other hand, redox perturbation that ensues from the GSH-depleting action of BSO activates nuclear translocation of Nrf2 as well as causing increased DNA-binding activity of NF-?
Localization (translocation) of Nrf2
19) Confidence 0.61 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.32 Pain Relevance 0.04
B (Fig. 3A, third panel) and substantial nuclear accumulation of Nrf2 (Fig. 3B, third panel). 24 h exposure to BSO does not cause toxicity in the cells (Fig. 2E).


Localization (accumulation) of Nrf2 associated with toxicity
20) Confidence 0.61 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.10 Pain Relevance 0

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