INT118393

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 2.82
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2) nucleus (Nfe2l2) DNA binding (Nfe2l2)
cytoplasm (Nfe2l2)
Anatomy Link Frequency
hepatocytes 2
liver 2
nucleus 2
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 46 99.90 Very High Very High Very High
qutenza 11 99.30 Very High Very High Very High
cINOD 9 86.32 High High
Glutamate 9 79.44 Quite High
Inflammatory response 8 73.44 Quite High
Inflammation 18 50.40 Quite High
Analgesic 5 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 106 97.96 Very High Very High Very High
Hepatotoxicity 5 95.40 Very High Very High Very High
Esophageal Disease 2 85.72 High High
Ulcers 2 85.12 High High
Injury 28 84.80 Quite High
Hepatocellular Cancer 4 83.48 Quite High
Skin Cancer 7 74.80 Quite High
Toxicity 77 73.68 Quite High
INFLAMMATION 29 73.08 Quite High
Targeted Disruption 22 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For each compound, greater than 60% depletion of GSH was achieved; however, in the case of BSO, this depletion did not cause nuclear translocation of Nrf2.
Neg (not) Positive_regulation (cause) of Localization (translocation) of Nrf2
1) Confidence 0.70 Published 2004 Journal Hepatology Section Abstract Doc Link 15122755 Disease Relevance 0.12 Pain Relevance 0.37
Here, we have investigated, in vivo, whether the ability of four murine hepatotoxins, paracetamol, bromobenzene (BB), carbon tetrachloride (CCl4) and furosemide (FS) to deplete hepatic glutathione (GSH) is related to induction of hepatic Nrf2 nuclear translocation and Nrf2-dependent gene expression.
Positive_regulation (induction) of Localization (translocation) of Nrf2 associated with paracetamol
2) Confidence 0.65 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.14 Pain Relevance 0.47
Additionally, we studied whether hepatic Nrf2 nuclear translocation is a general response during the early stages of acute hepatic chemical stress in vivo.
Spec (whether) Positive_regulation (response) of Spec (whether) Localization (translocation) of Nrf2 associated with stress
3) Confidence 0.47 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.16 Pain Relevance 0.54
We show that acetaminophen can initiate nuclear translocation of Nrf2 in vivo, with maximum levels reached after 1 hour, in a dose dependent manner, at doses below those causing overt liver damage.
Positive_regulation (initiate) of Localization (translocation) of Nrf2 in liver associated with paracetamol and hepatotoxicity
4) Confidence 0.47 Published 2004 Journal Hepatology Section Abstract Doc Link 15122755 Disease Relevance 0.27 Pain Relevance 0.41
Although exposure of hepatocytes to nimesulide was not associated with increased net levels of superoxide anion, nimesulide (100 microM, 24 h) caused nuclear translocation of Nrf2 in a sulfaphenazole-sensitive manner, indicating a role of electrophilic metabolites.
Positive_regulation (caused) of Localization (translocation) of Nrf2 in hepatocytes
5) Confidence 0.46 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.66 Pain Relevance 0.07
On the other hand, redox perturbation that ensues from the GSH-depleting action of BSO activates nuclear translocation of Nrf2 as well as causing increased DNA-binding activity of NF-?
Positive_regulation (activates) of Localization (translocation) of Nrf2
6) Confidence 0.41 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.32 Pain Relevance 0.04
B binding activity (Fig. 2B) and increased nuclear accumulation of Nrf2 (Fig. 2C), which correspond with GSH levels being depleted to below 20% of the basal level (Fig. 2A); a BSO-mediated increase in Nrf2 has been seen previously in our lab [18].
Positive_regulation (increased) of Localization (accumulation) of Nrf2
7) Confidence 0.41 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.13 Pain Relevance 0
Following a 1 h exposure, nuclear accumulation of Nrf2 increased with increasing concentrations of NAPQI (Fig. 1A) and DNCB (Fig. 1B); an increase in Nrf2 after exposure to NAPQI or DNCB has been demonstrated previously in our lab [18].
Positive_regulation (increased) of Localization (accumulation) of Nrf2
8) Confidence 0.38 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.08 Pain Relevance 0.18
This is in agreement with our previous finding in which BSO induced nuclear accumulation of Nrf2 [18] and findings by others in which BSO induced NF-?
Positive_regulation (induced) of Localization (accumulation) of Nrf2
9) Confidence 0.35 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.13 Pain Relevance 0
It has recently been shown that Protandim causes the translocation of Nrf2 to the nucleus [13].
Positive_regulation (causes) of Localization (translocation) of Nrf2 in nucleus
10) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.18 Pain Relevance 0.03
Capsaicin treatment resulted in a transient increase in the phosphorylation of Akt and subsequently nuclear translocation of NF-E2-related factor 2 (Nrf2), enhancing its binding to antioxidant response element (ARE).
Positive_regulation (increase) of Localization (translocation) of Nrf2 associated with qutenza
11) Confidence 0.17 Published 2007 Journal Antioxid. Redox Signal. Section Abstract Doc Link 17979524 Disease Relevance 0 Pain Relevance 0.58
Phosphorylation of extracellular regulating protein kinase (ERKs) and Akt, and nuclear translocation of nuclear related factor 2 (Nrf2) were induced by 150 microM eupatilin in a time-dependent manner.
Positive_regulation (induced) of Localization (translocation) of Nrf2
12) Confidence 0.13 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19336889 Disease Relevance 0.32 Pain Relevance 0.31
Phosphorylation of extracellular regulating protein kinase (ERKs) and Akt, and nuclear translocation of nuclear related factor 2 (Nrf2) were induced by 150 microM eupatilin in a time-dependent manner.
Positive_regulation (induced) of Localization (translocation) of factor 2
13) Confidence 0.11 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19336889 Disease Relevance 0.32 Pain Relevance 0.31

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