INT118394

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 1.40
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2) nucleus (Nfe2l2) DNA binding (Nfe2l2)
cytoplasm (Nfe2l2)
Anatomy Link Frequency
macrophages 2
livers 2
Germ line 2
nucleus 2
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 47 100.00 Very High Very High Very High
qutenza 12 99.98 Very High Very High Very High
Glutamate 9 84.56 Quite High
Inflammatory response 12 74.80 Quite High
dexamethasone 1 72.52 Quite High
Inflammation 69 61.36 Quite High
chemokine 3 36.92 Quite Low
cytokine 10 36.36 Quite Low
Analgesic 7 25.00 Low Low
adenocard 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 2 99.72 Very High Very High Very High
Neurodegenerative Disease 5 91.44 High High
Targeted Disruption 29 88.88 High High
Hepatocellular Cancer 5 83.48 Quite High
Hepatotoxicity 4 79.00 Quite High
Toxicity 94 77.84 Quite High
INFLAMMATION 83 74.80 Quite High
Stress 162 58.84 Quite High
Atherosclerosis 53 50.00 Quite Low
Repression 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, GSH depletion alone is insufficient for Nrf2 activation: a more direct interaction is required, possibly involving chemical modification of Nrf2 or Keap1, which is facilitated by the prior loss of GSH.
Positive_regulation (insufficient) of Positive_regulation (activation) of Nrf2
1) Confidence 0.70 Published 2004 Journal Hepatology Section Abstract Doc Link 15122755 Disease Relevance 0.06 Pain Relevance 0.30
Homozygous mice were viable and their livers displayed no apparent abnormalities, but nuclear accumulation of Nrf2 is elevated.
Positive_regulation (elevated) of Positive_regulation (accumulation) of Nrf2 in livers associated with congenital anomalies
2) Confidence 0.69 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16293230 Disease Relevance 0.17 Pain Relevance 0.08
In summary, we have demonstrated that the hepatotoxins BB, CCl4 and FS can induce a small but significant increase in Nrf2 accumulation in hepatic nuclei.
Positive_regulation (increase) of Positive_regulation (accumulation) of Nrf2
3) Confidence 0.65 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0 Pain Relevance 0.23
To investigate acetaminophen-induced Nrf2 activation we compared the actions of 2 other GSH depleters, diethyl maleate (DEM) and buthionine sulphoximine (BSO), only 1 of which (DEM) can function as a Michael acceptor.
Spec (investigate) Positive_regulation (acetaminophen-induced) of Positive_regulation (activation) of Nrf2 associated with paracetamol
4) Confidence 0.50 Published 2004 Journal Hepatology Section Abstract Doc Link 15122755 Disease Relevance 0.20 Pain Relevance 0.42
It is possible that both of these mechanisms contribute to the activation of Nrf2 by acetaminophen.
Spec (possible) Positive_regulation (contribute) of Positive_regulation (activation) of Nrf2 associated with paracetamol
5) Confidence 0.46 Published 2008 Journal Hepatology Section Abstract Doc Link 18785192 Disease Relevance 0 Pain Relevance 0.21
Germ line deletion of the keap1 gene results in constitutive activation of Nrf2, but the pups unexpectedly died before weaning.
Positive_regulation (results) of Positive_regulation (activation) of Nrf2 in Germ line
6) Confidence 0.46 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16293230 Disease Relevance 0.15 Pain Relevance 0.05
Does exogenous FLAG-CRIF1 affect the accumulation of exogenous His-V5-NRF2 at the enhancer region of HO-1?
Positive_regulation (-) of Positive_regulation (accumulation) of NRF2
7) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
B-p65 cellular abundance (Fig. 3A, second panel) and a clear increase in Nrf2 (Fig. 3B, second panel) accumulation in the nucleus after 1 h of DNCB treatment.
Positive_regulation (increase) of Positive_regulation (accumulation) of Nrf2 in nucleus
8) Confidence 0.41 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.07 Pain Relevance 0.15
It should be emphasized that the induction of Nrf2 and NF-?
Positive_regulation (emphasized) of Positive_regulation (induction) of Nrf2
9) Confidence 0.41 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.20 Pain Relevance 0.03
Following a 1 h exposure, nuclear accumulation of Nrf2 increased with increasing concentrations of NAPQI (Fig. 1A) and DNCB (Fig. 1B); an increase in Nrf2 after exposure to NAPQI or DNCB has been demonstrated previously in our lab [18].
Positive_regulation (increased) of Positive_regulation (accumulation) of Nrf2
10) Confidence 0.41 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.08 Pain Relevance 0.18
Following a 1 h exposure, nuclear accumulation of Nrf2 increased with increasing concentrations of NAPQI (Fig. 1A) and DNCB (Fig. 1B); an increase in Nrf2 after exposure to NAPQI or DNCB has been demonstrated previously in our lab [18].
Positive_regulation (increased) of Positive_regulation (increase) of Nrf2
11) Confidence 0.35 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.08 Pain Relevance 0.18
Our observations are in agreement with previous studies in animal and cell-based models that showed that NAPQI induces the activation of Nrf2 [18,27] and inhibits NF-?
Positive_regulation (induces) of Positive_regulation (activation) of Nrf2
12) Confidence 0.35 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0 Pain Relevance 0
Therefore, we speculate that increased microglial expression of Srxn1, Blvrb, and Gclm is also mediated by activation of Nrf2.
Positive_regulation (mediated) of Positive_regulation (activation) of Nrf2
13) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.23 Pain Relevance 0.07
Thus, ambient UFP triggers the induction of Nrf2-regulated HO-1 in macrophages to a greater degree than ambient PM2.5 or coarse particles [61].
Positive_regulation (triggers) of Positive_regulation (induction) of Nrf2 in macrophages
14) Confidence 0.20 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.15 Pain Relevance 0
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.
Positive_regulation (induces) of Positive_regulation (activation) of Nrf2 associated with qutenza
15) Confidence 0.17 Published 2007 Journal Antioxid. Redox Signal. Section Title Doc Link 17979524 Disease Relevance 0 Pain Relevance 0.91

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